Le site des publications & des preprint de l’IHU sur le COVID-19

Compte-tenu de la vitesse d’évolution de l’épidémie et des besoins de renseignements permanents pour la communauté scientifique, associé à la difficulté des déplacements, la fondation a décidé de mettre online les articles soumis (preprint), comme ont déjà commencé à le faire les sites mais qui dans la situation actuelle ont des délais trop importants pour être compatibles avec les besoins de rapidité que nous avons.

Dès aujourd’hui, toutes les publications que nous soumettrons seront mises en preprint sur notre site et seront remplacées par un lien vers une publication scientifique officielle, dès que ces articles seront acceptés et dans leur forme définitive.

Nous espérons que ceci permettra aux scientifiques du monde entier de suivre les travaux que nous menons dans cette situation épidémique.

The IHU publication and pre-publication site on COVID-19

Given the speed of evolution of the epidemic and the permanent information needs of the scientific community, combined with the difficulty of travel, the foundation has decided to put online the submitted articles (preprint), as have already started to do the sites but which in the current situation have deadlines too important to be compatible with the need for speed that we have.

As of today, all the publications that we will submit will be put in preprint on our site and will be replaced by a link to an official scientific publication, as soon as these articles are accepted and in their final form.

We hope that this will allow scientists around the world to follow our work in this epidemic situation.

Clinical observational studies and Cohorts

  • Lagier, J. C., Million, M., Gautret, P., Colson, P., Cortaredona, S., Giraud-Gatineau, A., Honoré, S., Gaubert, J. Y., Fournier, P. E., Tissot-Dupont, H., Chabrière, E., Stein, A., Deharo, J. C., Fenollar, F., Rolain, J. M., Obadia, Y., Jacquier, A., La Scola, B., Brouqui, P., Drancourt, M., … IHU COVID-19 Task force (2020).
    Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis.
    Travel medicine and infectious disease, 36, 101791. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315163/

 

 

 

  • Aherfi S, Gautret P, Chaudet H, Raoult D, La Scola B.
    Clusters of COVID-19 associated with Purim celebration in the Jewish community in Marseille, France, March 2020 [published online ahead of print, 2020 Aug 20].
    Int J Infect Dis. 2020;S1201-9712(20)30679-2. doi:10.1016/j.ijid.2020.08.049 https://pubmed.ncbi.nlm.nih.gov/32829043/

 

 

  • Colson P, Rolain JM, Raoult D.
    Chloroquine for the 2019 novel coronavirus SARS-CoV-2.
    Int J Antimicrob Agents. 2020;55(3):105923. doi:10.1016/j.ijantimicag.2020.105923 https://pubmed.ncbi.nlm.nih.gov/32070753/

 

  • Colson P, Rolain JM, Lagier JC, Brouqui P, Raoult D.
    Chloroquine and hydroxychloroquine as available weapons to fight COVID-19.
    Int J Antimicrob Agents. 2020;55(4):105932. doi:10.1016/j.ijantimicag.2020.105932 https://pubmed.ncbi.nlm.nih.gov/32145363/

 

 

  • Brouqui P, Giraud-Gatineau A, Raoult D.
    Remdesivir investigational trials in COVID-19: a critical reappraisal [published online ahead of print, 2020 Jun 7].
    New Microbes New Infect. 2020;100707. doi:10.1016/j.nmni.2020.100707 https://pubmed.ncbi.nlm.nih.gov/32837727/

 

 

  • Wargny M, Gourdy P, Ludwig L, Seret-Bégué D, Bourron O, Darmon P, Amadou C, Pichelin M, Potier L, Thivolet C, Gautier JF, Hadjadj S, Cariou B; CORONADO investigators.
    Type 1 Diabetes in People Hospitalized for COVID-19: New Insights From the CORONADO Study.
    Diabetes Care. 2020 Aug 26:dc201217. doi: 10.2337/dc20-1217. Epub ahead of print. PMID: 32847826.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576421/

 

  • Gonçalves A, Bertrand J, Ke R, Comets E, de Lamballerie X, Malvy D, Pizzorno A, Terrier O, Rosa Calatrava M, Mentré F, Smith P, Perelson AS, Guedj J.
    Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load.
    CPT Pharmacometrics Syst Pharmacol. 2020 Jun 18;9(9):509–14. doi: 10.1002/psp4.12543. Epub ahead of print. PMID: 32558354; PMCID: PMC7323384. https://pubmed.ncbi.nlm.nih.gov/32558354/

 

  • Eloy P, Solas C, Touret F, Mentré F, Malvy D, de Lamballerie X, Guedj J.
    Dose Rationale for Favipiravir Use in Patients Infected With SARS-CoV-2.
    Clin Pharmacol Ther. 2020 Aug;108(2):188. doi: 10.1002/cpt.1877. Epub 2020 May 21. PMID: 32350860. https://pubmed.ncbi.nlm.nih.gov/32350860/

 

  • Gautret, P., Lagier, J. C., Parola, P., Hoang, V. T., Meddeb, L., Mailhe, M., Doudier, B., Courjon, J., Giordanengo, V., Vieira, V. E., Tissot Dupont, H., Honoré, S., Colson, P., Chabrière, E., La Scola, B., Rolain, J. M., Brouqui, P., & Raoult, D. (2020).
    Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
    International journal of antimicrobial agents, 56(1), 105949. https://doi.org/10.1016/j.ijantimicag.2020.105949

 

  • Didier Raoult, Matthieu Million, Philippe Gautret, Jean-Christophe Lagier, Philippe Colson, Philippe Parola, and Jean-Marc Rolain.
    Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial : Response to David Spencer (Elsevier).
    Published online 08/07/2020: https://doi.org/10.35088/bjjr-cy47

 

  • Gautret, P., Lagier, J. C., Parola, P., Hoang, V. T., Meddeb, L., Sevestre, J., Mailhe, M., Doudier, B., Aubry, C., Amrane, S., Seng, P., Hocquart, M., Eldin, C., Finance, J., Vieira, V. E., Tissot-Dupont, H. T., Honoré, S., Stein, A., Million, M., Colson, P., … Raoult, D. (2020).
    Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
    Travel medicine and infectious disease, 34, 101663. https://doi.org/10.1016/j.tmaid.2020.101663 https://pubmed.ncbi.nlm.nih.gov/32289548/

 

  • Million, M., Lagier, J. C., Gautret, P., Colson, P., Fournier, P. E., Amrane, S., Hocquart, M., Mailhe, M., Esteves-Vieira, V., Doudier, B., Aubry, C., Correard, F., Giraud-Gatineau, A., Roussel, Y., Berenger, C., Cassir, N., Seng, P., Zandotti, C., Dhiver, C., Ravaux, I., … Raoult, D. (2020).
    Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France.
    Travel medicine and infectious disease, 35, 101738. https://doi.org/10.1016/j.tmaid.2020.101738 https://pubmed.ncbi.nlm.nih.gov/32387409/

 

  • La Scola, B., Le Bideau, M., Andreani, J., Hoang, V. T., Grimaldier, C., Colson, P., Gautret, P., & Raoult, D. (2020)
    Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 39(6), 1059–1061. https://doi.org/10.1007/s10096-020-03913-9https://pubmed.ncbi.nlm.nih.gov/32342252/

 

  • Baron SA, Devaux C, Colson P, Raoult D, Rolain JM.
    Teicoplanin: an alternative drug for the treatment of COVID-19?
    Int J Antimicrob Agents. 2020;55(4):105944. doi:10.1016/j.ijantimicag.2020.105944 https://pubmed.ncbi.nlm.nih.gov/32179150/

Tran Duc Anh Ly, Didier Zanini, Vincent Laforge, Sylvie Arlotto, Stephanie Gentile, Helene Mendizabal, Michaël Finaud, David Morel, Olivier Quenette, Priscilla Malfuson-Clot-Faybesse, Alain Midejean, Phuc Le-Dinh, Gérard Daher, Berengere Labarriere, Anne-Marie Morel-Roux, Alain Coquet, Patrick Augier, Philippe Parola, Eric Chabriere, Didier Raoult, Philippe Gautret
Pattern of SARS-CoV-2 infection among dependant elderly residents living in long-term care facilities in Marseille, France, March–June 2020
International Journal of Antimicrobial Agents, Available online 13 November 2020, 106219 https://www.sciencedirect.com/science/article/pii/S0924857920304301

VIROLOGY – ISOLATION – IN VITRO TESTING

 

  • Gendrot M, Andreani J, Boxberger M, Jardot P, Fonta I, Le Bideau M, Duflot I, Mosnier J, Rolland C, Bogreau H, Hutter S, La Scola B, Pradines B.
    Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation.
    Travel Med Infect Dis. 2020 Sep 8;37:101873. doi: 10.1016/j.tmaid.2020.101873. Epub ahead of print. PMID: 32916297; PMCID: PMC7477610. https://pubmed.ncbi.nlm.nih.gov/32916297/

 

  • Touret F, Gilles M, Barral K, Nougairède A, van Helden J, Decroly E, de Lamballerie X, Coutard B.
    In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication.
    Sci Rep. 2020 Aug 4;10(1):13093. doi: 10.1038/s41598-020-70143-6. PMID: 32753646; PMCID: PMC7403393. https://pubmed.ncbi.nlm.nih.gov/32753646/

 

  • Maisonnasse P, Guedj J, Contreras V, Behillil S, Solas C, Marlin R, Naninck T, Pizzorno A, Lemaitre J, Gonçalves A, Kahlaoui N, Terrier O, Fang RHT, Enouf V, Dereuddre-Bosquet N, Brisebarre A, Touret F, Chapon C, Hoen B, Lina B, Calatrava MR, van der Werf S, de Lamballerie X, Le Grand R.
    Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates.
    Nature. 2020 Sep;585(7826):584-587. doi: 10.1038/s41586-020-2558-4. Epub 2020 Jul 22. PMID: 32698191. https://pubmed.ncbi.nlm.nih.gov/32698191/

 

  • Pastorino B, Touret F, Gilles M, de Lamballerie X, Charrel RN.
    Heat Inactivation of Different Types of SARS-CoV-2 Samples: What Protocols for Biosafety, Molecular Detection and Serological Diagnostics?
    2020 Jul 7;12(7):735. doi: 10.3390/v12070735. PMID: 32646015; PMCID: PMC7412566. https://pubmed.ncbi.nlm.nih.gov/32646015/

 

  • Pastorino B, Touret F, Gilles M, Luciani L, de Lamballerie X, Charrel RN.
    Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples.
    2020 Jun 8;12(6):624. doi: 10.3390/v12060624. PMID: 32521706; PMCID: PMC7354533. https://pubmed.ncbi.nlm.nih.gov/32521706/

 

  • Gendrot M, Andreani J, Jardot P, Hutter S, Delandre O, Boxberger M, Mosnier J, Le Bideau M, Duflot I, Fonta I, Rolland C, Bogreau H, La Scola B, Pradines B.
    In vitro antiviral activity of doxycycline against SARS-CoV-2.
    Molecules, 2020, 25 :5064. Doi: 10.3390/molecules25215064 https://pubmed.ncbi.nlm.nih.gov/33142770/

 

  • Gendrot M, Andreani J, Duflot I, Boxberger M, Le Bideau M, Mosnier J, Jardot P, Fonta I, Rolland C, Bogreau H, Hutter S, La Scola B, Pradines B.
    Methylene blue inhibits the replication of SARS-CoV-2 in vitro.
    Int J Antimicrob Agents, 2020, 106202. Doi: 10.1016/j.ijantimicag.2020.106202 https://pubmed.ncbi.nlm.nih.gov/33075512/

 

  • Gendrot M, Duflot I, Boxberger M, Delandre O, Jardot P, Le Bideau M, Andreani J, Fonta I, Mosnier J, Rolland C, Hutter S, La Scola B, Pradines B.
    Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate.
    Int J Infect Dis, 2020, 99 :437-440. Doi: 10.1016/j.ijid.2020.08.032 https://pubmed.ncbi.nlm.nih.gov/32805422/

GENOMICS

  • Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E.
    The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
    Antiviral Res. 2020 Apr;176:104742. doi: 10.1016/j.antiviral.2020.104742. Epub 2020 Feb 10. PMID: 32057769; PMCID: PMC7114094.

MICROSCOPY

  • Francis R, Le Bideau M, Jardot P, Grimaldier C, Raoult D, Bou Khalil JY, La Scola B.
    High-speed large-scale automated isolation of SARS-CoV-2 from clinical samples using miniaturized co-culture coupled to high-content screening.
    Clin Microbiol Infect. 2020 Sep 23:S1198-743X(20)30570-X. doi: 10.1016/j.cmi.2020.09.018. Epub ahead of print. PMID: 32979576; PMCID: PMC7510445.

 

  • Colson P, Lagier JC, Baudoin JP, Bou Khalil J, La Scola B, Raoult D.
    Ultrarapid diagnosis, microscope imaging, genome sequencing, and culture isolation of SARS-CoV-2.
    Eur J Clin Microbiol Infect Dis. 2020;39(8):1601-1603. doi:10.1007/s10096-020-03869-w https://pubmed.ncbi.nlm.nih.gov/32270412/

 

  • Djamal Brahim Belhaouari, Anthony Fontanini, Jean-Pierre Baudoin, Gabriel Haddad, Marion Le Bideau, Jacques Yaacoub Bou Khalil, Didier Raoult and Bernard La Scola.
    The strengths of scanning electron microscopy in deciphering SARS-CoV-2 infectious cycle.
    Frontiers in Microbiology VOLUME=11 YEAR=2020 PAGES=2014   3389/fmicb.2020.02014 https://www.frontiersin.org/article/10.3389/fmicb.2020.02014

IMMUNOLOGY

 

  • Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen J, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort, Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL. Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020 Sep 24:eabd4585. doi: 10.1126/science.abd4585. Epub ahead of print. PMID: 32972996.

 

  • Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Çölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela ŞN, Gallego CR, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-19; Biobank; COVID Human Genetic Effort; NIAID-USUHS; TAGC COVID Immunity Group, Snow AL, Dalgard CL, Milner J, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli M, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton R, Zhang SY, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science. 2020 Sep 24:eabd4570. doi: 10.1126/science.abd4570. Epub ahead of print. PMID: 32972995.

 

  • Melenotte C, Silvin A, Goubet AG, Lahmar I, Dubuisson A, Zumla A, Raoult D, Merad M, Gachot B, Hénon C, Solary E, Fontenay M, André F, Maeurer M, Ippolito G, Piacentini M, Wang FS, Ginhoux F, Marabelle A, Kroemer G, Derosa L, Zitvogel L.
    Immune responses during COVID-19 infection.
    Oncoimmunology. 2020 Aug 25;9(1):1807836. doi: 10.1080/2162402X.2020.1807836. PMID: 32939324; PMCID: PMC7480812.

 

  • Vitte J, Michel M, Mezouar S, Diallo AB, Boumaza A, Mege JL, Desnues B.
    Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines.
    Front Immunol. 2020 Aug 28;11:2159. doi: 10.3389/fimmu.2020.02159. PMID: 32983179; PMCID: PMC7484884.

 

  • Vitte J, Diallo AB, Boumaza A, Lopez A, Michel M, Allardet-Servent J, Mezouar S, Sereme Y, Busnel JM, Miloud T, Malergue F, Morange PE, Halfon P, Olive D, Leone M, Mege JL.
    A granulocytic signature identifies COVID-19 and its severity.
    J Infect Dis. 2020 Sep 17:jiaa591. doi: 10.1093/infdis/jiaa591. Epub ahead of print. PMID: 32941618; PMCID: PMC7543529.
  • Pierre-Edouard FOURNIER,
    Contribution of VitaPCR SARS-CoV-2 to the emergency diagnosis of COVID-19
    In press Journal of Clinical Virology.

DIAGNOSIS

  • Amrane, S., Tissot-Dupont, H., Doudier, B., Eldin, C., Hocquart, M., Mailhe, M., Dudouet, P., Ormières, E., Ailhaud, L., Parola, P., Lagier, J. C., Brouqui, P., Zandotti, C., Ninove, L., Luciani, L., Boschi, C., La Scola, B., Raoult, D., Million, M., Colson, P., … Gautret, P. (2020).
    Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France – January 31st to March 1st, 2020: A respiratory virus snapshot.
    Travel medicine and infectious disease, 101632. Advance online publication. https://doi.org/10.1016/j.tmaid.2020.101632

 

  • Boudjema S, Finance J, Coulibaly F, Meddeb L, Tissot-Dupont H, Michel M, Lagier JC, Million M, Radulesco T, Michel J, Brouqui P, Raoult D, Fenollar F, Parola P.
    Olfactory and gustative disorders for the diagnosis of COVID-19.
    Travel Med Infect Dis. 2020 Sep 6;37:101875. doi: 10.1016/j.tmaid.2020.101875. Epub ahead of print. PMID: 32898703; PMCID: PMC7474847.

 

  • Jaafar R, Aherfi S, Wurtz N, Grimaldier C, Hoang VT, Colson P, Raoult D, La Scola B.
    Correlation between 3790 qPCR positives samples and positive cell cultures including 1941 SARS-CoV-2 isolates.
    Clin Infect Dis. 2020 Sep 28:ciaa1491. doi: 10.1093/cid/ciaa1491. Epub ahead of print. PMID: 32986798; PMCID: PMC7543373.

 

  • Pezzi L, Charrel RN, Ninove L, Nougairede A, Molle G, Coutard B, Durand G, Leparc-Goffart I, de Lamballerie X, Thirion L.
    Development and Evaluation of a duo SARS-CoV-2 RT-qPCR Assay Combining Two Assays Approved by the World Health Organization Targeting the Envelope and the RNA-Dependant RNA Polymerase (RdRp) Coding Regions.
    Viruses. 2020 Jun 25;12(6):686. doi: 10.3390/v12060686. PMID: 32630601; PMCID: PMC7354606.

 

  • Pastorino B, Touret F, Gilles M, de Lamballerie X, Charrel RN.
    Prolonged Infectivity of SARS-CoV-2 in Fomites.
    Emerg Infect Dis. 2020 Sep;26(9):2256–7. doi: 10.3201/eid2609.201788. Epub 2020 Jun 24. PMID: 32579874; PMCID: PMC7454106.

 

  • Nathalie Wurtz, Gwilherm Penant, Priscilla Jardot, Nathalie Duclos and Bernard La Scola
    Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity and differences in growth profile
    European Journal of Clinical Microbiology & Infectious Diseases

EPIDEMIOLOGY

 

  • Giraud-Gatineau, A., Colson, P., Jimeno, M. T., Zandotti, C., Ninove, L., Boschi, C., Lagier, J. C., La Scola, B., Chaudet, H., & Raoult, D. (2020).
    Comparison of mortality associated with respiratory viral infections between December 2019 and March 2020 with that of the previous year in Southeastern France.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 96, 154–156. https://doi.org/10.1016/j.ijid.2020.05.001. https://pubmed.ncbi.nlm.nih.gov/32389848/

 

  • Colson, P., Tissot-Dupont, H., Morand, A., Boschi, C., Ninove, L., Esteves-Vieira, V., Gautret, P., Brouqui, P., Parola, P., Lagier, J. C., Zandotti, C., Million, M., La Scola, B., & Raoult, D. (2020).
    Children account for a small proportion of diagnoses of SARS-CoV-2 infection and do not exhibit greater viral loads than adults.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1–5. Advance online publication. https://doi.org/10.1007/s10096-020-03900-0https://pubmed.ncbi.nlm.nih.gov/32845413/

 

  • Colson, P., La Scola, B., Esteves-Vieira, V., Ninove, L., Zandotti, C., Jimeno, M. T., Gazin, C., Bedotto, M., Filosa, V., Giraud-Gatineau, A., Chaudet, H., Brouqui, P., Lagier, J. C., & Raoult, D. (2020).
    Letter to the editor: Plenty of coronaviruses but no SARS-CoV-2.
    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 25(8), 2000171. https://doi.org/10.2807/1560-7917.ES.2020.25.8.2000171. https://pubmed.ncbi.nlm.nih.gov/32127122/

 

  • Colson P, Esteves-Vieira V, Giraud-Gatineau A, Zandotti C, Filosa V, Chaudet H, Lagier JC, Raoult D.
    Temporal and age distributions of SARS-CoV-2 and other coronaviruses, Southeastern France.
    Int J Infect Dis. 2020 Sep 22:S1201-9712(20)32133-0. doi: 10.1016/j.ijid.2020.09.1417. Epub ahead of print. PMID: 32976991; PMCID: PMC7511210.

 

  • Gautret P, Colson P, Lagier JC, Camoin-Jau L, Giraud-Gatineau A, Boudjema S, Finance J, Chaudet H, Raoult D.
    Different pattern of the second outbreak of COVID-19 in Marseille, France.
    Int J Infect Dis. 2020 Oct 7:S1201-9712(20)32208-6. doi: 10.1016/j.ijid.2020.10.005. Epub ahead of print. PMID: 33038556.

 

  • Gallian P, Pastorino B, Morel P, Chiaroni J, Ninove L, de Lamballerie X.
    Lower prevalence of antibodies neutralizing SARS-CoV-2 in group O French blood donors.
    Antiviral Res. 2020 Sep;181:104880. doi: 10.1016/j.antiviral.2020.104880. Epub 2020 Jul 15. PMID: 32679056; PMCID: PMC7362788.

 

  • Laloui R, Bakour S, Raoult D, Verger P, Sokhna C, Devaux C, Pradines B, Rolain JM.
    What could explain the late emergence of COVID-19 in Africa?
    New Microbes New Infect, 2020, 38 :100760. Doi: 10.1016/j.nmni.2020.100760

HUMAN AND SOCIAL SCIENCES

  • Ward JK, Alleaume C, Peretti-Watel P; COCONEL Group.
    The French public’s attitudes to a future COVID-19 vaccine: The politicization of a public health issue.
    Social Science and Medicine, 265:113414. doi: 10.1016/j.socscimed.2020.113414.

 

  • COCONEL Study Group.
    Attitudes about COVID-19 Lockdown among General Population, France, March 2020.
    Emerging Infectious Diseases (à paraître).

 

  • Peretti-Watel P, Alleaume C, Léger D, Beck F, Verger P.
    Anxiety, depression and sleep problems: a second wave of COVID-19.
    General Psychiatry, 33 (5) e100299; DOI: 10.1136/gpsych-2020-100299.

 

  • Léger D., Beck F., Fressard L., Verger P., Peretti-Watel P., and the COCONEL Group.
    Poor Sleep Associated with Overuse of Media during the COVID-19 Lockdown.
    Sleep doi: 10.1093/sleep/zsaa125.

 

  • Patrick Peretti-Watel and the COCONEL Study Group.
    A future vaccination campaign against COVID-19 at risk of vaccine hesitancy and politicization.
    Lancet Infectious Diseases, 2020. doi: 10.1016/S1473-3099(20)30426-6.

 

  • Beck F., Léger D., Fressard L., Peretti-Watel P., Verger P. & the COCONEL group.
    Covid-19 health crisis and lockdown associated with high level of sleep complaints and hypnotic uptake at the population level.
    Journal of Sleep Research. doi: 10.1111/jsr.13119.

 

  • Lambert A, Cayouette-Remblière J,  Guéraut É,  Le Roux G,  Bonvalet C,  Girard V,  Langlois L.
    Le travail et ses aménagements : ce que la pandémie de covid-19a changé pour les Français,
    Population & Sociétés, Numéro 579,

 

  • Lambert A, Cayouette-Remblière J, Guéraut É, Le Roux G, Bonvalet C, Girard V, Langlois L.
    Comment voisine-t-on dans la France confinée ?
    Population & Sociétés, Numéro 578, juillet 2020.

COMMENTARIES – PERSPECTIVES

  • Lagier, J. C., Colson, P., Tissot Dupont, H., Salomon, J., Doudier, B., Aubry, C., Gouriet, F., Baron, S., Dudouet, P., Flores, R., Ailhaud, L., Gautret, P., Parola, P., La Scola, B., Raoult, D., & Brouqui, P. (2020).
    Testing the repatriated for SARS-Cov2: Should laboratory-based quarantine replace traditional quarantine?
    Travel medicine and infectious disease, 34, 101624. https://doi.org/10.1016/j.tmaid.2020.101624https://pubmed.ncbi.nlm.nih.gov/32179125/

 

 

 

  • Javelle E, Raoult D.
    COVID-19 pandemic more than a century after the Spanish flu [published online ahead of print, 2020 Aug 11].
    Lancet Infect Dis. 2020;S1473-3099(20)30650-2. doi:10.1016/S1473-3099(20)30650-2 https://pubmed.ncbi.nlm.nih.gov/32795410/

 

  • Raoult D, Zumla A, Locatelli F, Ippolito G, Kroemer G.
    Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses.
    Cell Stress. 2020;4(4):66-75. Published 2020 Mar 2. doi:10.15698/cst2020.04.216 https://pubmed.ncbi.nlm.nih.gov/32292881/

 

  • Devaux CA, Rolain JM, Raoult D.
    ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome.
    J Microbiol Immunol Infect. 2020;53(3):425-435. doi:10.1016/j.jmii.2020.04.015 https://pubmed.ncbi.nlm.nih.gov/32414646/

 

  • Roussel Y, Raoult D.
    Hydroxychloroquine recommendations toward the world: first evaluations.
    New Microbes New Infect. 2020 Sep 22:100759. doi: 10.1016/j.nmni.2020.100759. Epub ahead of print. PMID: 32983541; PMCID: PMC7508006.

 

 

  • Lalaoui R, Bakour S, Raoult D, Verger P, Sokhna C, Devaux C, Pradines B, Rolain JM.
    What could explain the late emergence of COVID-19 in Africa?
    New Microbes New Infect. 2020 Nov;38:100760. doi: 10.1016/j.nmni.2020.100760. Epub 2020 Sep 22. PMID: 32983542; PMCID: PMC7508045.

 

  • Raoult D.
    Lancet gate: a matter of fact or a matter of concern.
    New Microbes New Infect. 2020 Nov;38:100758. doi: 10.1016/j.nmni.2020.100758. Epub 2020 Sep 22. PMID: 32983540; PMCID: PMC7508049.

 

  • Million M, Roussel Y, Lagier JC, Raoult D.
    Re: ‘effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients’ by Fiolet et al.
    Clin Microbiol Infect. 2020 Sep 24:S1198-743X(20)30578-4. doi: 10.1016/j.cmi.2020.09.026. Epub ahead of print. PMID: 32980527.

 

  • Touret F, de Lamballerie X.
    Of chloroquine and COVID-19.
    Antiviral Res. 2020 May;177:104762. doi: 10.1016/j.antiviral.2020.104762. Epub 2020 Mar 5. PMID: 32147496; PMCID: PMC7132364.

 

  • Frutos R, Serra-Cobo J, Chen T, Devaux CA.
    COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans.
    Infect Genet Evol. 2020 Oct;84:104493. doi: 10.1016/j.meegid.2020.104493. Epub 2020 Aug 5. PMID: 32768565; PMCID: PMC7405773.

 

  • Frutos R, Lopez Roig M, Serra-Cobo J, Devaux CA.
    COVID-19: The Conjunction of Events Leading to the Coronavirus Pandemic and Lessons to Learn for Future Threats.
    Front Med (Lausanne). 2020 May 12;7:223. doi: 10.3389/fmed.2020.00223. PMID: 32574324; PMCID: PMC7235412.

 

  • Devaux CA, Rolain JM, Colson P, Raoult D.
    New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
    Int J Antimicrob Agents. 2020;55(5):105938. doi:10.1016/j.ijantimicag.2020.105938 https://pubmed.ncbi.nlm.nih.gov/32171740/

 

  • Raoult D.
    Rational for meta-analysis and randomized treatment: the COVID-19 example.
    Clin Microbiol Infect. 2020 Oct 21:S1198-743X(20)30643-1. doi: 10.1016/j.cmi.2020.10.012. Epub ahead of print. PMID: 33098998.

 

  • Roussel Y, Million M, Chabriere E, Lagier JC, Raoult D.
    Be careful with Big Data: Re-analysis of Patient Characteristics and Outcomes of 11,721 Patients with COVID19 Hospitalized Across the United States.
    Clin Infect Dis. 2020 Oct 22:ciaa1618. doi: 10.1093/cid/ciaa1618. Epub ahead of print. PMID: 33086376.

 

  • Devaux C.
    Are ACE inhibitors and ARBs more beneficial than harmful in the treatment of severe COVID-19 disease?
    J. Cardiovascular Med. Cardio. : 7(2): 101-103. DOI: https://dx.doi.org/10.17352/2455-2976.000122

 

  • Gendrot M, Javelle E, Clerc A, Savini H, Pradines B.
    Chloroquine as a prophylactic agent against COVID-19?
    Int J Antimicrob Agents, 2020, 55 :105980. Doi: 10.1016/j.ijantimicag.2020.105980

CLINICAL OBSERVATIONAL STUDIES AND COHORTS

Version 1 du 24 novembre 2020
Re: Covid-19: politicisation, “corruption,” and suppression of science
Matthieu MILLION, Didier RAOULT

Link to the article

Version 1 du 13 Mai 2020
Screening of SARS-CoV-2 among homeless people, asylum-seekers and other people living in precarious conditions in Marseille, France, March–April 2020.
Tran Duc Anh Ly, Van Thuan Hoang, Ndiaw Goumballa, Meriem Louni, Naomie Canard, Thi Loi Dao, Hacene Medkour, Audrey Borg, Kevin Bardy, Véra EstevesVieira, Véronique Filosa, Bernard Davoust, Oleg Mediannikov, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret

Link to the article

Version 1 du 08 Juin 2020
Adjusting series of patients for trial comparisons for COVID-19 treatments
Audrey GIRAUD-GATINEAU, Jean-Christophe LAGIER, Yolande OBADIA, Hervé CHAUDET, Didier RAOULT

DOI : https://doi.org/10.35088/fk6j-n864

Version 1 du 22 avril 2020
Response to Magagnoli, MedRxiv, 2020
Matthieu MILLION, Yanis ROUSSEL, Didier RAOULT

Link to the article

Version 1 du 22 avril 2020
Combination of hydroxychloroquine plus azithromycin as potential treatment for COVID 19 patients: pharmacology, safety profile, drug interactions and management of toxicity.
Guillaume Hache, Jean Marc Rolain, Philippe Gautret, JeanClaude Deharo, Philippe Brouqui, Didier Raoult, Stéphane Honoré

Link to the article

Version 1 du 24 septembre 2020
Hydroxychloroquine and Azithromycin as a Treatment of COVID-19: Results of an Open-Label Non-Randomized Clinical Trial: Response to criticisms
Didier Raoult, Matthieu Million, Jean-Christophe Lagier, Philippe Colson, Philippe Parola, Jean-Marc Rolain, Philippe Gautret

Link to the article
Figure 1A
Figure 1B
Supplement data

GENOMICS

Version 1 du 07 septembre 2020
Dramatic increase in the SARS-CoV-2 mutation rate and low mortality rate during the second epidemic in summer in Marseille
Philippe COLSON, Anthony LEVASSEUR, Jeremy DELERCE, Hervé CHAUDET, Vincent BOSSI, Mariem BEN KHEDHER, Pierre-Edouard FOURNIER, Jean-Christophe LAGIER, Didier RAOULT

doi: https://doi.org/10.35088/68c3-ew82

IMMUNOLOGY

Version 1 du 08 septembre 2020
High prevalence of Lupus Anticoagulant in Ambulatory COVID-19 patients: interest of Hydroxychloroquine ?
Laurence Camoin-Jau, Philippe Gautret, Philippe Colson, Jean Christophe Lagier, Hervé Tissot-Dupont, Matthieu Million, Audrey Giraud-Gatineau, Sophia Boudjema, Hervé Chaudet, Didier Raoult

Link to the article

Version 1 du 14 septembre 2020
Daytime variation in SARS-CoV-2 infection and cytokine production
Aissatou Bailo Diallo, Laetitia Gay, Benjamin Coiffard, Marc Leone, Soraya Mezouar, Jean-Louis Mège

Link to the article : https://www.biorxiv.org/content/10.1101/2020.09.09.290718v1

Version 1 du 21 septembre 2020
Monocytes and macrophages, targets of SARS-CoV-2: the clue for Covid-19 immunoparalysis
Asma Boumaza, Laetitia Gay, Soraya Mezouar, Aïssatou Bailo Diallo, Moise Michel1,2, Benoit Desnues1,2, Didier Raoult1,2, Bernard La Scola1,2, Philippe Halfon, Joana Vitte, Daniel Olive and Jean-Louis Mege

Link to the article

DIAGNOSTIC

Version 2 du 24 septembre 2020
Evaluating the serological status of COVID-19 patients using an indirect immunofluorescent assay, France
S. Edouard, P. Colson, C. Melenotte, F. De Pinto, L. Thomas, B. La Scola, M. Million, H. Tissot-Dupont, P. Gautret, A. Stein, P. Brouqui, P. Parola, J-C Lagier, D. Raoult, M. Drancourt

Link to the article
Figures 1-2-3-4-S1
Tables 1 et 2

Version 1 du 12 octobre 2020
Living SARS-CoV-2 in feces suggesting possible fecal-oral contamination
Julie Dergham, Jeremy Delerce, Marielle Bedotto, Bernard La Scola, Valérie Moal

Link to the article

ÉPIDÉMIOLOGIE

Version 1 du 10 Juin 2020
Open screening of SARS-CoV-2 infections in the pediatric population in Marseille, Southern France
Aurélie Morand, PhD, MD1,2*, Tatiana Matteudi1, Alexandre Fabre, PhD, MD3,4, Philippe Minodier, MD5, Emmanuelle Bosdure, MD1, Léa Luciani, PharmD2, Jean-Christophe Dubus, PhD, MD1,6, Matthieu Million, PhD, MD2,6, Hervé Tissot-Dupont, MD2,6, Bernard La Scola, PhD, MD2,6, Philippe Colson, PhD, PharmD2,6, Didier Raoult, PhD, MD2,6, Brigitte Chabrol, PhD, MD1

In this cohort study we reported the first 302 pediatric SARS-CoV-2-positive patients in Marseille, mainly diagnosed thanks to open screening platform (80%).

Link to the article

Version 1 du 1er septembre 2020
Differences pattern of the second outbreak of COVID-19 in Marseille, France
Philippe Gautret, Philippe Colson, Jean Christophe Lagier, Laurence Camoin-Jau, Audrey Giraud-Gatineau, Sophia Boudjema, Hervé Chaude, Didier Raoult

DOI : https://doi.org/10.35088/gsye-fd42

Title page
Table 1
Figure 1

Version 2 du 30 mars 2020
Decreased mortality associated with respiratory viral infections between December 2019 and March 2020 compared to previous year, Southeast France
Audrey GIRAUD-GATINEAU, Philippe COLSON, Marie-Thérèse JIMENO, Christine ZANDOTTI, Laetitia NINOVE, Céline BOSCHI, JeanChristophe LAGIER, Bernard LA SCOLA, Hervé CHAUDET, Didier RAOULT

Link to the article

COMMENTARIES – PERSPECTIVES

Version 1 du 21 août 2020
Quousque tandem abutere, patientia nostra – Article soumis et rejeté par The New England Journal of Medecine
Didier Raoult, M.D, Ph.D., Jean-Christophe Lagier M.D, Ph.D., Philippe Brouqui, M.D., Ph.D., Philippe Parola, M.D, Ph.D.

Link to the article

Version 1 du 30 juin 2020
Does IHU Mediterranean Infection influence Gilead stock price ?
Eric Chabrière

DOI : https://doi.org/10.35088/82z6-3×49

Version 2 du 18 Juin 2020
Randomised Controlled Trials during epidemic
Philippe Brouqui, Didier Raoult

In epidemics there is an urgent need for new knowledge on drug efficacy to help policymakers fight the crisis. Yet the best research methodology to do this is a matter of debate, write Philippe Brouqui and Didier Raoult.

DOI : https://doi.org/10.35088/hedm-be95

SUBMITTED

Omar Osman I et al.
Expression of ACE2 receptor, soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin (1-7), is modulated in COVID-19 patients
JCI: submitted

Frutos R et al.
Understanding the origin of COVID-19 requires to change the paradigm for zoonotic emergence
Trends Microbiol.: submitted.

 

Devaux C.
Can ACE2 receptor polymorphism predict species susceptibility to SARS-CoV-2 ?
Front public health: submitted/research square DOI: 10.21203/rs.3.rs-25753/v1

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