Publications & preprint IHU

Clinical observational studies and Cohorts

• Van-Thuan Hoang, Philippe Colson, Anthony Levasseur, Jérémy Delerce, Jean-Christophe Lagier, Philippe Parola, Matthieu Million, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret
  Clinical outcomes in patients infected with different SARS-CoV-2 variants at one hospital during three phases of the COVID-19 epidemic in Marseille, France
• Link : https://www.sciencedirect.com/science/article/pii/S1567134821003907?dgcid=coauthor

• Jean-Christophe Lagier, Sophie Amrane, Morgane Mailhe, Marc Gainnier, Sylvie Arlotto, Stéphanie Gentile and Didier Raoult
  High-flow oxygen therapy in elderly patients infected with SARS-CoV2 with a contraindication for transfer to an intensive care unit
  Link : https://www.ijidonline.com/article/S1201-9712(21)00305-2/fulltext

• Bouam, A., Vincent, J.J., Le Glass, E., Almeras, L., Tissot-Dupont, H., Lagier, J.-C., Fournier, P.-E., Raoult, D., Drancourt, M.
  Rapid isothermal amplification detection of buccal SARS-CoV-2 for ambulatory screening of COVID-19
  J. Clin. Med.2021, 10(12), 2643
  Abstract: https://www.mdpi.com/2077-0383/10/12/2643
  PDF Version: https://www.mdpi.com/2077-0383/10/12/2643/pdf

• Julie Finance, Laurent Zieleskewicz, Paul Habert , Alexis Jacquier, Philippe Parola, Alain Boussuges , Fabienne Bregeon , Carole Eldin
  Non-radiating and low-radiating imaging for diagnosis and management of COVID-19 pneumonia
  J. Clin. Med. 2021, 10, 2196. https://doi.org/10.3390/jcm10102196 : https://www.mdpi.com/2077-0383/10/10/2196/pdf

• Lagier, J. C., Million, M., Gautret, P., Colson, P., Cortaredona, S., Giraud-Gatineau, A., Honoré, S., Gaubert, J. Y., Fournier, P. E., Tissot-Dupont, H., Chabrière, E., Stein, A., Deharo, J. C., Fenollar, F., Rolain, J. M., Obadia, Y., Jacquier, A., La Scola, B., Brouqui, P., Drancourt, M., … IHU COVID-19 Task force (2020).
  Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis.
  Travel medicine and infectious disease, 36, 101791. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315163/

• Philippe Brouqui, Philippe Colson, Cléa Melenotte, Linda Houhamdi, Marielle Bedotto, Christian Devaux, Philipe Gautret, Matthieu Million, Philippe Parola, Didier Stoupan, Bernard La Scola, Jean-Christophe Lagier, Didier Raoult
  COVID-19 re-infection
  European Society for Clinical Investigation Journal Foundation –  https://onlinelibrary.wiley.com/doi/10.1111/eci.13537

• Morand, A., Roquelaure, B., Colson, P., Amrane, S., Bosdure, E., Raoult, D., Lagier, J. C., & Fabre, A. (2020).
  Child with liver transplant recovers from COVID-19 infection.
  A case report. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 27(5), 275–276. https://doi.org/10.1016/j.arcped.2020.05.004 https://pubmed.ncbi.nlm.nih.gov/32402433/

• Amatore, F., Macagno, N., Mailhe, M., Demarez, B., Gaudy-Marqueste, C., Grob, J. J., Raoult, D., Brouqui, P., & Richard, M. A. (2020).
  SARS-CoV-2 infection presenting as a febrile rash.
  Journal of the European Academy of Dermatology and Venereology : JEADV, 34(7), e304–e306. https://doi.org/10.1111/jdv.16528 https://pubmed.ncbi.nlm.nih.gov/32330336/

• Aherfi S, Gautret P, Chaudet H, Raoult D, La Scola B.
  Clusters of COVID-19 associated with Purim celebration in the Jewish community in Marseille, France, March 2020 [published online ahead of print, 2020 Aug 20].
  Int J Infect Dis. 2020;S1201-9712(20)30679-2. doi:10.1016/j.ijid.2020.08.049 https://pubmed.ncbi.nlm.nih.gov/32829043/

• Guedj, E., Million, M., Dudouet, P., Tissot-Dupont, H., Bregeon, F., Cammilleri, S., & Raoult, D. (2020).
  18F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders?
  European journal of nuclear medicine and molecular imaging, 1–4. Advance online publication. https://doi.org/10.1007/s00259-020-04973-xhttps://pubmed.ncbi.nlm.nih.gov/32728799/

• Colson P, Rolain JM, Raoult D.
  Chloroquine for the 2019 novel coronavirus SARS-CoV-2.
  Int J Antimicrob Agents. 2020;55(3):105923. doi:10.1016/j.ijantimicag.2020.105923 https://pubmed.ncbi.nlm.nih.gov/32070753/

• Colson P, Rolain JM, Lagier JC, Brouqui P, Raoult D.
  Chloroquine and hydroxychloroquine as available weapons to fight COVID-19.
  Int J Antimicrob Agents. 2020;55(4):105932. doi:10.1016/j.ijantimicag.2020.105932 https://pubmed.ncbi.nlm.nih.gov/32145363/

• Raoult D, Hsueh PR, Stefani S, Rolain JM.
  COVID-19 Therapeutic and Prevention.
  Int J Antimicrob Agents. 2020;55(4):105937. doi:10.1016/j.ijantimicag.2020.105937 https://pubmed.ncbi.nlm.nih.gov/32151714/

• Brouqui P, Giraud-Gatineau A, Raoult D.
  Remdesivir investigational trials in COVID-19: a critical reappraisal [published online ahead of print, 2020 Jun 7].
  New Microbes New Infect. 2020;100707. doi:10.1016/j.nmni.2020.100707 https://pubmed.ncbi.nlm.nih.gov/32837727/

• Matthieu MILLION, Yanis ROUSSEL, Jean-Christophe LAGIER, Didier RAOULT
  Re: Effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients : a systematic review and meta-analysis.
  Published on-line 01/09/2020. IHU Méditerranée Infection #30. Accepted in Clinical Microbiology and Infection https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Response-to-Fiolet-et-al-Manuscript.pdf

• Wargny M, Gourdy P, Ludwig L, Seret-Bégué D, Bourron O, Darmon P, Amadou C, Pichelin M, Potier L, Thivolet C, Gautier JF, Hadjadj S, Cariou B; CORONADO investigators.
  Type 1 Diabetes in People Hospitalized for COVID-19: New Insights From the CORONADO Study.
  Diabetes Care. 2020 Aug 26:dc201217. doi: 10.2337/dc20-1217. Epub ahead of print. PMID: 32847826.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576421/

• Gonçalves A, Bertrand J, Ke R, Comets E, de Lamballerie X, Malvy D, Pizzorno A, Terrier O, Rosa Calatrava M, Mentré F, Smith P, Perelson AS, Guedj J.
  Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load.
  CPT Pharmacometrics Syst Pharmacol. 2020 Jun 18;9(9):509–14. doi: 10.1002/psp4.12543. Epub ahead of print. PMID: 32558354; PMCID: PMC7323384. https://pubmed.ncbi.nlm.nih.gov/32558354/

• Eloy P, Solas C, Touret F, Mentré F, Malvy D, de Lamballerie X, Guedj J.
  Dose Rationale for Favipiravir Use in Patients Infected With SARS-CoV-2.
  Clin Pharmacol Ther. 2020 Aug;108(2):188. doi: 10.1002/cpt.1877. Epub 2020 May 21. PMID: 32350860. https://pubmed.ncbi.nlm.nih.gov/32350860/

• Gautret, P., Lagier, J. C., Parola, P., Hoang, V. T., Meddeb, L., Mailhe, M., Doudier, B., Courjon, J., Giordanengo, V., Vieira, V. E., Tissot Dupont, H., Honoré, S., Colson, P., Chabrière, E., La Scola, B., Rolain, J. M., Brouqui, P., & Raoult, D. (2020).
  Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
  International journal of antimicrobial agents, 56(1), 105949. https://doi.org/10.1016/j.ijantimicag.2020.105949

• Didier Raoult, Matthieu Million, Philippe Gautret, Jean-Christophe Lagier, Philippe Colson, Philippe Parola, and Jean-Marc Rolain.
  Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial : Response to David Spencer (Elsevier).
  Published online 08/07/2020: https://doi.org/10.35088/bjjr-cy47

• Gautret, P., Lagier, J. C., Parola, P., Hoang, V. T., Meddeb, L., Sevestre, J., Mailhe, M., Doudier, B., Aubry, C., Amrane, S., Seng, P., Hocquart, M., Eldin, C., Finance, J., Vieira, V. E., Tissot-Dupont, H. T., Honoré, S., Stein, A., Million, M., Colson, P., … Raoult, D. (2020).
  Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
  Travel medicine and infectious disease, 34, 101663. https://doi.org/10.1016/j.tmaid.2020.101663 https://pubmed.ncbi.nlm.nih.gov/32289548/

• Million, M., Lagier, J. C., Gautret, P., Colson, P., Fournier, P. E., Amrane, S., Hocquart, M., Mailhe, M., Esteves-Vieira, V., Doudier, B., Aubry, C., Correard, F., Giraud-Gatineau, A., Roussel, Y., Berenger, C., Cassir, N., Seng, P., Zandotti, C., Dhiver, C., Ravaux, I., … Raoult, D. (2020).
  Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France.
  Travel medicine and infectious disease, 35, 101738. https://doi.org/10.1016/j.tmaid.2020.101738 https://pubmed.ncbi.nlm.nih.gov/32387409/

• La Scola, B., Le Bideau, M., Andreani, J., Hoang, V. T., Grimaldier, C., Colson, P., Gautret, P., & Raoult, D. (2020)
  Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.
  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 39(6), 1059–1061. https://doi.org/10.1007/s10096-020-03913-9https://pubmed.ncbi.nlm.nih.gov/32342252/

• Baron SA, Devaux C, Colson P, Raoult D, Rolain JM.
  Teicoplanin: an alternative drug for the treatment of COVID-19?
  Int J Antimicrob Agents. 2020;55(4):105944. doi:10.1016/j.ijantimicag.2020.105944 https://pubmed.ncbi.nlm.nih.gov/32179150/

Tran Duc Anh Ly, Didier Zanini, Vincent Laforge, Sylvie Arlotto, Stephanie Gentile, Helene Mendizabal, Michaël Finaud, David Morel, Olivier Quenette, Priscilla Malfuson-Clot-Faybesse, Alain Midejean, Phuc Le-Dinh, Gérard Daher_, Berengere Labarriere, Anne-Marie Morel-Roux, Alain Coquet, Patrick Augier, Philippe Parola, Eric Chabriere, Didier Raoult, Philippe Gautret
Pattern of SARS-CoV-2 infection among dependant elderly residents living in long-term care facilities in Marseille, France, March–June 2020
International Journal of Antimicrobial Agents, Available online 13 November 2020, 106219 https://www.sciencedirect.com/science/article/pii/S0924857920304301

VIROLOGY – ISOLATION – IN VITRO TESTING

• Gendrot M, Jardot P, Delandre O, Boxberger M, Andreani J, Duflot I, Le Bideau M, Mosnier J, Fonta I, Hutter S, La Scola B, Pradines B.
  In vitro evaluation of the antiviral activity of methylene blue alone or in combination against SARS-CoV-2.
  J Clin Med 2021, 10, 3007.
  DOI : https://doi.org/10.3390/jcm10143007

• Julie Dergham, Jeremy Delerce, Marielle Bedotto, Bernard La Scola, Valérie Moal
  Isolation of viable SARS-CoV-2 in feces suggesting possible fecal transmission of COVID-19
  J. Clin. Med. 2021, 10, 2696. https://doi.org/10.3390/jcm10122696
  Abstract: https://www.mdpi.com/2077-0383/10/12/2696
  PDF Version: https://www.mdpi.com/2077-0383/10/12/2696/pdf

• Andreani, J., Le Bideau, M., Duflot, I., Jardot, P., Rolland, C., Boxberger, M., Wurtz, N., Rolain, J. M., Colson, P., La Scola, B., & Raoult, D. (2020).
  In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect.
  Microbial pathogenesis, 145, 104228. https://doi.org/10.1016/j.micpath.2020.104228https://pubmed.ncbi.nlm.nih.gov/32344177/

• Gendrot M, Andreani J, Boxberger M, Jardot P, Fonta I, Le Bideau M, Duflot I, Mosnier J, Rolland C, Bogreau H, Hutter S, La Scola B, Pradines B.
  Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation.
  Travel Med Infect Dis. 2020 Sep 8;37:101873. doi: 10.1016/j.tmaid.2020.101873. Epub ahead of print. PMID: 32916297; PMCID: PMC7477610. https://pubmed.ncbi.nlm.nih.gov/32916297/

• Touret F, Gilles M, Barral K, Nougairède A, van Helden J, Decroly E, de Lamballerie X, Coutard B.
  In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication.
  Sci Rep. 2020 Aug 4;10(1):13093. doi: 10.1038/s41598-020-70143-6. PMID: 32753646; PMCID: PMC7403393. https://pubmed.ncbi.nlm.nih.gov/32753646/

• Maisonnasse P, Guedj J, Contreras V, Behillil S, Solas C, Marlin R, Naninck T, Pizzorno A, Lemaitre J, Gonçalves A, Kahlaoui N, Terrier O, Fang RHT, Enouf V, Dereuddre-Bosquet N, Brisebarre A, Touret F, Chapon C, Hoen B, Lina B, Calatrava MR, van der Werf S, de Lamballerie X, Le Grand R.
  Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates.
  Nature. 2020 Sep;585(7826):584-587. doi: 10.1038/s41586-020-2558-4. Epub 2020 Jul 22. PMID: 32698191. https://pubmed.ncbi.nlm.nih.gov/32698191/

• Pastorino B, Touret F, Gilles M, de Lamballerie X, Charrel RN.
  Heat Inactivation of Different Types of SARS-CoV-2 Samples: What Protocols for Biosafety, Molecular Detection and Serological Diagnostics?
  2020 Jul 7;12(7):735. doi: 10.3390/v12070735. PMID: 32646015; PMCID: PMC7412566. https://pubmed.ncbi.nlm.nih.gov/32646015/

• Pastorino B, Touret F, Gilles M, Luciani L, de Lamballerie X, Charrel RN.
  Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples.
  2020 Jun 8;12(6):624. doi: 10.3390/v12060624. PMID: 32521706; PMCID: PMC7354533. https://pubmed.ncbi.nlm.nih.gov/32521706/

• Gendrot M, Andreani J, Jardot P, Hutter S, Delandre O, Boxberger M, Mosnier J, Le Bideau M, Duflot I, Fonta I, Rolland C, Bogreau H, La Scola B, Pradines B.
  In vitro antiviral activity of doxycycline against SARS-CoV-2.
  Molecules, 2020, 25 :5064. Doi: 10.3390/molecules25215064 https://pubmed.ncbi.nlm.nih.gov/33142770/

• Gendrot M, Andreani J, Duflot I, Boxberger M, Le Bideau M, Mosnier J, Jardot P, Fonta I, Rolland C, Bogreau H, Hutter S, La Scola B, Pradines B.
  Methylene blue inhibits the replication of SARS-CoV-2 in vitro.
  Int J Antimicrob Agents, 2020, 106202. Doi: 10.1016/j.ijantimicag.2020.106202 https://pubmed.ncbi.nlm.nih.gov/33075512/

• Gendrot M, Duflot I, Boxberger M, Delandre O, Jardot P, Le Bideau M, Andreani J, Fonta I, Mosnier J, Rolland C, Hutter S, La Scola B, Pradines B.
  Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate.
  Int J Infect Dis, 2020, 99 :437-440. Doi: 10.1016/j.ijid.2020.08.032 https://pubmed.ncbi.nlm.nih.gov/32805422/

GENOMICS

• Van Thuan Hoang, Philippe Colson, Anthony Levasseur, Jérémy Delerce, Jean-Christophe Lagier, Philippe Parola, Matthieu Million, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret
  Clinical outcomes in patients infected with different SARS-CoV-2 variants at one hospital during three phases of the COVID-19 epidemic in Marseille, France
  https://doi.org/10.1016/j.meegid.2021.105092
• Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E.
  The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
  Antiviral Res. 2020 Apr;176:104742. doi: 10.1016/j.antiviral.2020.104742. Epub 2020 Feb 10. PMID: 32057769; PMCID: PMC7114094.

MICROSCOPY

• Francis R, Le Bideau M, Jardot P, Grimaldier C, Raoult D, Bou Khalil JY, La Scola B.
  High-speed large-scale automated isolation of SARS-CoV-2 from clinical samples using miniaturized co-culture coupled to high-content screening.
  Clin Microbiol Infect. 2020 Sep 23:S1198-743X(20)30570-X. doi: 10.1016/j.cmi.2020.09.018. Epub ahead of print. PMID: 32979576; PMCID: PMC7510445.

• Colson P, Lagier JC, Baudoin JP, Bou Khalil J, La Scola B, Raoult D.
  Ultrarapid diagnosis, microscope imaging, genome sequencing, and culture isolation of SARS-CoV-2.
  Eur J Clin Microbiol Infect Dis. 2020;39(8):1601-1603. doi:10.1007/s10096-020-03869-w https://pubmed.ncbi.nlm.nih.gov/32270412/

• Djamal Brahim Belhaouari, Anthony Fontanini, Jean-Pierre Baudoin, Gabriel Haddad, Marion Le Bideau, Jacques Yaacoub Bou Khalil, Didier Raoult and Bernard La Scola.
  The strengths of scanning electron microscopy in deciphering SARS-CoV-2 infectious cycle.
  Frontiers in Microbiology VOLUME=11 YEAR=2020 PAGES=2014   3389/fmicb.2020.02014 https://www.frontiersin.org/article/10.3389/fmicb.2020.02014

IMMUNOLOGY

• Bertin, D., Brodovitch, A., Beziane, A., Hug, S., Bouamri, A., Mege, J. L., & Bardin, N. (2020).
  Anti-cardiolipin IgG autoantibodies are an independent risk factor of COVID-19 severity.
  Arthritis & rheumatology (Hoboken, N.J.), 10.1002/art.41409. Advance online publication. https://doi.org/10.1002/art.41409https://pubmed.ncbi.nlm.nih.gov/32564467/

• Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen J, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort, Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL. Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020 Sep 24:eabd4585. doi: 10.1126/science.abd4585. Epub ahead of print. PMID: 32972996.

• Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Çölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela ŞN, Gallego CR, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-19; Biobank; COVID Human Genetic Effort; NIAID-USUHS; TAGC COVID Immunity Group, Snow AL, Dalgard CL, Milner J, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli M, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton R, Zhang SY, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science. 2020 Sep 24:eabd4570. doi: 10.1126/science.abd4570. Epub ahead of print. PMID: 32972995.

• Melenotte C, Silvin A, Goubet AG, Lahmar I, Dubuisson A, Zumla A, Raoult D, Merad M, Gachot B, Hénon C, Solary E, Fontenay M, André F, Maeurer M, Ippolito G, Piacentini M, Wang FS, Ginhoux F, Marabelle A, Kroemer G, Derosa L, Zitvogel L.
  Immune responses during COVID-19 infection.
  Oncoimmunology. 2020 Aug 25;9(1):1807836. doi: 10.1080/2162402X.2020.1807836. PMID: 32939324; PMCID: PMC7480812.

• Vitte J, Michel M, Mezouar S, Diallo AB, Boumaza A, Mege JL, Desnues B.
  Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines.
  Front Immunol. 2020 Aug 28;11:2159. doi: 10.3389/fimmu.2020.02159. PMID: 32983179; PMCID: PMC7484884.

• Vitte J, Diallo AB, Boumaza A, Lopez A, Michel M, Allardet-Servent J, Mezouar S, Sereme Y, Busnel JM, Miloud T, Malergue F, Morange PE, Halfon P, Olive D, Leone M, Mege JL.
  A granulocytic signature identifies COVID-19 and its severity.
  J Infect Dis. 2020 Sep 17:jiaa591. doi: 10.1093/infdis/jiaa591. Epub ahead of print. PMID: 32941618; PMCID: PMC7543529.

• Pierre-Edouard FOURNIER,
  Contribution of VitaPCR SARS-CoV-2 to the emergency diagnosis of COVID-19
  In press Journal of Clinical Virology.

DIAGNOSIS

• Melo Costa M, Benoit N, Tissot-Dupont H, Million M, Pradines B, Granjeaud S, Almeras L. Mouth
  Washing impaired SARS-CoV-2 detection in saliva
  Diagnostics 2021, 11, 1509
  DOI: https://doi.org/10.3390/diagnostics11081509

• Melo Costa M, Benoit N, Saby F, Pradines B, Granjeaud S, Almeras L.
  Optimization and standardization of human saliva collection for MALDI-TOF MS.
  Diagnostics 2021, 11, 1304.
  doi: https://doi.org/10.3390/diagnostics11081304

• Melo Costa M, Benoit N, Dormoi J, Amalvict R, Gomez N, Tissot-Dupont H, Million M, Pradines B, Grandjeud S, Almeras L.
  Salivette, a relevant saliva sampling device for SARS-CoV-2 detection
  J Oral Microbiol 2021, 13, 1920226.
  DOI: https://doi.org/10.1080/20002297.2021.1920226

• Philippe COLSON, Christian A DEVAUX and Didier RAOULT
  A possible role of COVID-19 therapy in the selective sweep and emergence of new SARS-CoV-2 variants
  Abstract: https://www.mdpi.com/2077-0383/10/15/3276
  PDF Version: https://www.mdpi.com/2077-0383/10/15/3276/pdf
  Special Issue: https://www.mdpi.com/journal/jcm/special_issues/Public_Health_COVID

• Amrane, S., Tissot-Dupont, H., Doudier, B., Eldin, C., Hocquart, M., Mailhe, M., Dudouet, P., Ormières, E., Ailhaud, L., Parola, P., Lagier, J. C., Brouqui, P., Zandotti, C., Ninove, L., Luciani, L., Boschi, C., La Scola, B., Raoult, D., Million, M., Colson, P., … Gautret, P. (2020).
  Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France – January 31st to March 1st, 2020: A respiratory virus snapshot.
  Travel medicine and infectious disease, 101632. Advance online publication. https://doi.org/10.1016/j.tmaid.2020.101632

• Boudjema S, Finance J, Coulibaly F, Meddeb L, Tissot-Dupont H, Michel M, Lagier JC, Million M, Radulesco T, Michel J, Brouqui P, Raoult D, Fenollar F, Parola P.
  Olfactory and gustative disorders for the diagnosis of COVID-19.
  Travel Med Infect Dis. 2020 Sep 6;37:101875. doi: 10.1016/j.tmaid.2020.101875. Epub ahead of print. PMID: 32898703; PMCID: PMC7474847.

• Jaafar R, Aherfi S, Wurtz N, Grimaldier C, Hoang VT, Colson P, Raoult D, La Scola B.
  Correlation between 3790 qPCR positives samples and positive cell cultures including 1941 SARS-CoV-2 isolates.
  Clin Infect Dis. 2020 Sep 28:ciaa1491. doi: 10.1093/cid/ciaa1491. Epub ahead of print. PMID: 32986798; PMCID: PMC7543373.

• Pezzi L, Charrel RN, Ninove L, Nougairede A, Molle G, Coutard B, Durand G, Leparc-Goffart I, de Lamballerie X, Thirion L.
  Development and Evaluation of a duo SARS-CoV-2 RT-qPCR Assay Combining Two Assays Approved by the World Health Organization Targeting the Envelope and the RNA-Dependant RNA Polymerase (RdRp) Coding Regions.
  Viruses. 2020 Jun 25;12(6):686. doi: 10.3390/v12060686. PMID: 32630601; PMCID: PMC7354606.

• Pastorino B, Touret F, Gilles M, de Lamballerie X, Charrel RN.
  Prolonged Infectivity of SARS-CoV-2 in Fomites.
  Emerg Infect Dis. 2020 Sep;26(9):2256–7. doi: 10.3201/eid2609.201788. Epub 2020 Jun 24. PMID: 32579874; PMCID: PMC7454106.

• Nathalie Wurtz, Gwilherm Penant, Priscilla Jardot, Nathalie Duclos and Bernard La Scola
  Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity and differences in growth profile
  European Journal of Clinical Microbiology & Infectious Diseases

EPIDEMIOLOGY

• Lancei KABA, Audrey GIRAUD-GATINEAU, Marie-Thérèse JIMENO, Jean-Marc ROLAIN, Philippe COLSON, Didier RAOULT, Hervé CHAUDET
  Consequences of the COVID-19 Outbreak Lockdown on Non-Viral Infectious Agents as Reported by a Laboratory-Based Surveillance System at the IHU Méditerranée Infection, Marseille, France
  Abstract: https://www.mdpi.com/2077-0383/10/15/3210
  PDF Version: https://www.mdpi.com/2077-0383/10/15/3210/pdf
  Special Issue: https://www.mdpi.com/journal/jcm/special_issues/Public_Health_COVID

• Younes Laidoudi, Youssouf Sereme, Hacène Medkour, Stéphanie Watier-Grillot, Pierre Scandola, Jacques Ginesta, Virginie Andréo, Claire Labarde, Loïc Comtet, Philippe Pourquier, Didier Raoult, Jean-Lou Marié, Bernard Davoust
  SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assay
  One Health 13 (2021) 100293
  Link to the PDF version

• Audrey GIRAUD-GATINEAU; Philippe GAUTRET; Philippe COLSON; Hervé CHAUDET; Didier RAOULT
  Evaluation of strategies to fight COVID-19: The French paradigm
  J. Clin. Med. 2021, 10, 2942. https://doi.org/10.3390/jcm10132942
  Abstract: https://www.mdpi.com/2077-0383/10/13/2942
  PDF Version: https://www.mdpi.com/2077-0383/10/13/2942/pdf
  
  
• Thi Loi Dao, Van Thuan Hoang, Philippe Colson, Jean Christophe Lagier, Didier Raoult , Anthony Levasseur , Philippe Gautret, Matthieu Million
  SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence
  J. Clin. Med. 2021, 10, 2635. https://doi.org/10.3390/jcm10122635
  Abstract: https://www.mdpi.com/2077-0383/10/12/2635
  PDF Version: https://www.mdpi.com/2077-0383/10/12/2635/pdf

• Pierre-Edouard FOURNIER, Sophie EDOUARD, Nathalie WURTZ , Justine RACLOT, Marion BECHET, Christine ZANDOTTI, Véronique FILOSA, Didier RAOULT, Florence FENOLLAR
  Contagion management at the Mediterranée Infection University Hospital Institute
  J. Clin. Med. 2021, 10, 2627. https://doi.org/10.3390/jcm10122627
  Abstract: https://www.mdpi.com/2077-0383/10/12/2627
  PDF Version: https://www.mdpi.com/2077-0383/10/12/2627/pdf

• Roussel, Y., Giraud-Gatineau, A., Jimeno, M. T., Rolain, J. M., Zandotti, C., Colson, P., & Raoult, D. (2020).
  SARS-CoV-2: fear versus data.
  International journal of antimicrobial agents, 55(5), 105947. https://doi.org/10.1016/j.ijantimicag.2020.105947 https://pubmed.ncbi.nlm.nih.gov/32201354/

• Giraud-Gatineau, A., Colson, P., Jimeno, M. T., Zandotti, C., Ninove, L., Boschi, C., Lagier, J. C., La Scola, B., Chaudet, H., & Raoult, D. (2020).
  Comparison of mortality associated with respiratory viral infections between December 2019 and March 2020 with that of the previous year in Southeastern France.
  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 96, 154–156. https://doi.org/10.1016/j.ijid.2020.05.001. https://pubmed.ncbi.nlm.nih.gov/32389848/

• Colson, P., Tissot-Dupont, H., Morand, A., Boschi, C., Ninove, L., Esteves-Vieira, V., Gautret, P., Brouqui, P., Parola, P., Lagier, J. C., Zandotti, C., Million, M., La Scola, B., & Raoult, D. (2020).
  Children account for a small proportion of diagnoses of SARS-CoV-2 infection and do not exhibit greater viral loads than adults.
  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1–5. Advance online publication. https://doi.org/10.1007/s10096-020-03900-0https://pubmed.ncbi.nlm.nih.gov/32845413/

• Colson, P., La Scola, B., Esteves-Vieira, V., Ninove, L., Zandotti, C., Jimeno, M. T., Gazin, C., Bedotto, M., Filosa, V., Giraud-Gatineau, A., Chaudet, H., Brouqui, P., Lagier, J. C., & Raoult, D. (2020).
  Letter to the editor: Plenty of coronaviruses but no SARS-CoV-2.
  Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 25(8), 2000171. https://doi.org/10.2807/1560-7917.ES.2020.25.8.2000171. https://pubmed.ncbi.nlm.nih.gov/32127122/

• Colson P, Esteves-Vieira V, Giraud-Gatineau A, Zandotti C, Filosa V, Chaudet H, Lagier JC, Raoult D.
  Temporal and age distributions of SARS-CoV-2 and other coronaviruses, Southeastern France.
  Int J Infect Dis. 2020 Sep 22:S1201-9712(20)32133-0. doi: 10.1016/j.ijid.2020.09.1417. Epub ahead of print. PMID: 32976991; PMCID: PMC7511210.

• Gautret P, Colson P, Lagier JC, Camoin-Jau L, Giraud-Gatineau A, Boudjema S, Finance J, Chaudet H, Raoult D.
  Different pattern of the second outbreak of COVID-19 in Marseille, France.
  Int J Infect Dis. 2020 Oct 7:S1201-9712(20)32208-6. doi: 10.1016/j.ijid.2020.10.005. Epub ahead of print. PMID: 33038556.

• Gallian P, Pastorino B, Morel P, Chiaroni J, Ninove L, de Lamballerie X.
  Lower prevalence of antibodies neutralizing SARS-CoV-2 in group O French blood donors.
  Antiviral Res. 2020 Sep;181:104880. doi: 10.1016/j.antiviral.2020.104880. Epub 2020 Jul 15. PMID: 32679056; PMCID: PMC7362788.

• Laloui R, Bakour S, Raoult D, Verger P, Sokhna C, Devaux C, Pradines B, Rolain JM.
  What could explain the late emergence of COVID-19 in Africa?
  New Microbes New Infect, 2020, 38 :100760. Doi: 10.1016/j.nmni.2020.100760

HUMAN AND SOCIAL SCIENCES

• Ward JK, Alleaume C, Peretti-Watel P; COCONEL Group.
  The French public’s attitudes to a future COVID-19 vaccine: The politicization of a public health issue.
  Social Science and Medicine, 265:113414. doi: 10.1016/j.socscimed.2020.113414.

• COCONEL Study Group.
  Attitudes about COVID-19 Lockdown among General Population, France, March 2020.
  Emerging Infectious Diseases (à paraître).

• Peretti-Watel P, Alleaume C, Léger D, Beck F, Verger P.
  Anxiety, depression and sleep problems: a second wave of COVID-19.
  General Psychiatry, 33 (5) e100299; DOI: 10.1136/gpsych-2020-100299.

• Léger D., Beck F., Fressard L., Verger P., Peretti-Watel P., and the COCONEL Group.
  Poor Sleep Associated with Overuse of Media during the COVID-19 Lockdown.
  Sleep doi: 10.1093/sleep/zsaa125.

• Patrick Peretti-Watel and the COCONEL Study Group.
  A future vaccination campaign against COVID-19 at risk of vaccine hesitancy and politicization.
  Lancet Infectious Diseases, 2020. doi: 10.1016/S1473-3099(20)30426-6.

• Beck F., Léger D., Fressard L., Peretti-Watel P., Verger P. & the COCONEL group.
  Covid-19 health crisis and lockdown associated with high level of sleep complaints and hypnotic uptake at the population level.
  Journal of Sleep Research. doi: 10.1111/jsr.13119.

• Lambert A, Cayouette-Remblière J,  Guéraut É,  Le Roux G,  Bonvalet C,  Girard V,  Langlois L.
  Le travail et ses aménagements : ce que la pandémie de covid-19a changé pour les Français,
  Population & Sociétés, Numéro 579,

• Lambert A, Cayouette-Remblière J, Guéraut É, Le Roux G, Bonvalet C, Girard V, Langlois L.
  Comment voisine-t-on dans la France confinée ?
  Population & Sociétés, Numéro 578, juillet 2020.

COMMENTARIES – PERSPECTIVES

• Philippe Brouqui, Michel Drancourt, Didier Raoult and on behalf of the IHU Task Force
  COVID-19 Management at IHU Méditerranée Infection: A One-Year Experience
  J. Clin. Med. 2021, 10, 2881. https://doi.org/10.3390/jcm10132881
  Abstract: https://www.mdpi.com/2077-0383/10/13/2881
  PDF Version: https://www.mdpi.com/2077-0383/10/13/2881/pdf
  

• Lagier, J. C., Colson, P., Tissot Dupont, H., Salomon, J., Doudier, B., Aubry, C., Gouriet, F., Baron, S., Dudouet, P., Flores, R., Ailhaud, L., Gautret, P., Parola, P., La Scola, B., Raoult, D., & Brouqui, P. (2020).
  Testing the repatriated for SARS-Cov2: Should laboratory-based quarantine replace traditional quarantine?
  Travel medicine and infectious disease, 34, 101624. https://doi.org/10.1016/j.tmaid.2020.101624https://pubmed.ncbi.nlm.nih.gov/32179125/

• Christian A. Devaux, Laurence Camoin-Jau, Jean-Louis Mege, Didier Raoult (2020)
  Can hydroxychloroquine be protective against COVID-19-associated thrombotic events ?
  Journal of Microbiology, Immunology and Infection
  https://www.sciencedirect.com/science/article/pii/S1684118221000074?via%3Dihub

   

• ChristianA.Devaux, LucilePinault, IkramOmarOsman, DidierRaoult (2021)
  Can ACE2 Receptor Polymorphism Predict Species Susceptibility to SARS-CoV-2 ?
  Frontiers in Public Health
  https://www.frontiersin.org/articles/10.3389/fpubh.2020.608765/full

• Gautret P, Raoult D.
  Nullane salus extra ecclesiam.
  New Microbes New Infect. 2020;37:100714. doi:10.1016/j.nmni.2020.100714 https://pubmed.ncbi.nlm.nih.gov/32834899/

• Million M, Roussel Y, Raoult D.
  Chloroquine and COVID-19: A western medical and scientific drift?
  Eur J Intern Med. 2020;78:4-5. doi:10.1016/j.ejim.2020.06.020 https://pubmed.ncbi.nlm.nih.gov/32600860/

• Javelle E, Raoult D.
  COVID-19 pandemic more than a century after the Spanish flu [published online ahead of print, 2020 Aug 11].
  Lancet Infect Dis. 2020;S1473-3099(20)30650-2. doi:10.1016/S1473-3099(20)30650-2 https://pubmed.ncbi.nlm.nih.gov/32795410/

• Raoult D, Zumla A, Locatelli F, Ippolito G, Kroemer G.
  Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses.
  Cell Stress. 2020;4(4):66-75. Published 2020 Mar 2. doi:10.15698/cst2020.04.216 https://pubmed.ncbi.nlm.nih.gov/32292881/

• Devaux CA, Rolain JM, Raoult D.
  ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome.
  J Microbiol Immunol Infect. 2020;53(3):425-435. doi:10.1016/j.jmii.2020.04.015 https://pubmed.ncbi.nlm.nih.gov/32414646/

• Roussel Y, Raoult D.
  Hydroxychloroquine recommendations toward the world: first evaluations.
  New Microbes New Infect. 2020 Sep 22:100759. doi: 10.1016/j.nmni.2020.100759. Epub ahead of print. PMID: 32983541; PMCID: PMC7508006.

• Million, M., Chaudet, H., & Raoult, D. (2020).
  Hydroxychloroquine Failure: The End does not justify the Means.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ciaa1117. Advance online publication. https://doi.org/10.1093/cid/ciaa1117https://pubmed.ncbi.nlm.nih.gov/32761148/

• Lalaoui R, Bakour S, Raoult D, Verger P, Sokhna C, Devaux C, Pradines B, Rolain JM.
  What could explain the late emergence of COVID-19 in Africa?
  New Microbes New Infect. 2020 Nov;38:100760. doi: 10.1016/j.nmni.2020.100760. Epub 2020 Sep 22. PMID: 32983542; PMCID: PMC7508045.

• Raoult D.
  Lancet gate: a matter of fact or a matter of concern.
  New Microbes New Infect. 2020 Nov;38:100758. doi: 10.1016/j.nmni.2020.100758. Epub 2020 Sep 22. PMID: 32983540; PMCID: PMC7508049.

• Million M, Roussel Y, Lagier JC, Raoult D.
  Re: ‘effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients’ by Fiolet et al.
  Clin Microbiol Infect. 2020 Sep 24:S1198-743X(20)30578-4. doi: 10.1016/j.cmi.2020.09.026. Epub ahead of print. PMID: 32980527.

• Touret F, de Lamballerie X.
  Of chloroquine and COVID-19.
  Antiviral Res. 2020 May;177:104762. doi: 10.1016/j.antiviral.2020.104762. Epub 2020 Mar 5. PMID: 32147496; PMCID: PMC7132364.

• Frutos R, Serra-Cobo J, Chen T, Devaux CA.
  COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans.
  Infect Genet Evol. 2020 Oct;84:104493. doi: 10.1016/j.meegid.2020.104493. Epub 2020 Aug 5. PMID: 32768565; PMCID: PMC7405773.

• Frutos R, Lopez Roig M, Serra-Cobo J, Devaux CA.
  COVID-19: The Conjunction of Events Leading to the Coronavirus Pandemic and Lessons to Learn for Future Threats.
  Front Med (Lausanne). 2020 May 12;7:223. doi: 10.3389/fmed.2020.00223. PMID: 32574324; PMCID: PMC7235412.

• Devaux CA, Rolain JM, Colson P, Raoult D.
  New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
  Int J Antimicrob Agents. 2020;55(5):105938. doi:10.1016/j.ijantimicag.2020.105938 https://pubmed.ncbi.nlm.nih.gov/32171740/

• Raoult D.
  Rational for meta-analysis and randomized treatment: the COVID-19 example.
  Clin Microbiol Infect. 2020 Oct 21:S1198-743X(20)30643-1. doi: 10.1016/j.cmi.2020.10.012. Epub ahead of print. PMID: 33098998.

• Roussel Y, Million M, Chabriere E, Lagier JC, Raoult D.
  Be careful with Big Data: Re-analysis of Patient Characteristics and Outcomes of 11,721 Patients with COVID19 Hospitalized Across the United States.
  Clin Infect Dis. 2020 Oct 22:ciaa1618. doi: 10.1093/cid/ciaa1618. Epub ahead of print. PMID: 33086376.

• Devaux C.
  Are ACE inhibitors and ARBs more beneficial than harmful in the treatment of severe COVID-19 disease?
  J. Cardiovascular Med. Cardio. : 7(2): 101-103. DOI: https://dx.doi.org/10.17352/2455-2976.000122

• Gendrot M, Javelle E, Clerc A, Savini H, Pradines B.
  Chloroquine as a prophylactic agent against COVID-19?
  Int J Antimicrob Agents, 2020, 55 :105980. Doi: 10.1016/j.ijantimicag.2020.105980