Le site des publications & des preprint de l’IHU sur le COVID-19
Compte-tenu de la vitesse d’évolution de l’épidémie et des besoins de renseignements permanents pour la communauté scientifique, associé à la difficulté des déplacements, la fondation a décidé de mettre online les articles soumis (preprint), comme ont déjà commencé à le faire les sites mais qui dans la situation actuelle ont des délais trop importants pour être compatibles avec les besoins de rapidité que nous avons.
Dès aujourd’hui, toutes les publications que nous soumettrons seront mises en preprint sur notre site et seront remplacées par un lien vers une publication scientifique officielle, dès que ces articles seront acceptés et dans leur forme définitive.
Nous espérons que ceci permettra aux scientifiques du monde entier de suivre les travaux que nous menons dans cette situation épidémique.
The IHU publication and pre-publication site on COVID-19
Given the speed of evolution of the epidemic and the permanent information needs of the scientific community, combined with the difficulty of travel, the foundation has decided to put online the submitted articles (preprint), as have already started to do the sites but which in the current situation have deadlines too important to be compatible with the need for speed that we have.
As of today, all the publications that we will submit will be put in preprint on our site and will be replaced by a link to an official scientific publication, as soon as these articles are accepted and in their final form.
We hope that this will allow scientists around the world to follow our work in this epidemic situation.
Clinical observational studies and Cohorts
- Lagier, J. C., Million, M., Gautret, P., Colson, P., Cortaredona, S., Giraud-Gatineau, A., Honoré, S., Gaubert, J. Y., Fournier, P. E., Tissot-Dupont, H., Chabrière, E., Stein, A., Deharo, J. C., Fenollar, F., Rolain, J. M., Obadia, Y., Jacquier, A., La Scola, B., Brouqui, P., Drancourt, M., … IHU COVID-19 Task force (2020).
Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis.
Travel medicine and infectious disease, 36, 101791. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315163/
- Morand, A., Roquelaure, B., Colson, P., Amrane, S., Bosdure, E., Raoult, D., Lagier, J. C., & Fabre, A. (2020).
Child with liver transplant recovers from COVID-19 infection.
A case report. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 27(5), 275–276. https://doi.org/10.1016/j.arcped.2020.05.004 https://pubmed.ncbi.nlm.nih.gov/32402433/
- Amatore, F., Macagno, N., Mailhe, M., Demarez, B., Gaudy-Marqueste, C., Grob, J. J., Raoult, D., Brouqui, P., & Richard, M. A. (2020).
SARS-CoV-2 infection presenting as a febrile rash.
Journal of the European Academy of Dermatology and Venereology : JEADV, 34(7), e304–e306. https://doi.org/10.1111/jdv.16528 https://pubmed.ncbi.nlm.nih.gov/32330336/
- Aherfi S, Gautret P, Chaudet H, Raoult D, La Scola B.
Clusters of COVID-19 associated with Purim celebration in the Jewish community in Marseille, France, March 2020 [published online ahead of print, 2020 Aug 20].
Int J Infect Dis. 2020;S1201-9712(20)30679-2. doi:10.1016/j.ijid.2020.08.049 https://pubmed.ncbi.nlm.nih.gov/32829043/
- Guedj, E., Million, M., Dudouet, P., Tissot-Dupont, H., Bregeon, F., Cammilleri, S., & Raoult, D. (2020).
18F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders?
European journal of nuclear medicine and molecular imaging, 1–4. Advance online publication. https://doi.org/10.1007/s00259-020-04973-xhttps://pubmed.ncbi.nlm.nih.gov/32728799/
- Colson P, Rolain JM, Raoult D.
Chloroquine for the 2019 novel coronavirus SARS-CoV-2.
Int J Antimicrob Agents. 2020;55(3):105923. doi:10.1016/j.ijantimicag.2020.105923 https://pubmed.ncbi.nlm.nih.gov/32070753/
- Colson P, Rolain JM, Lagier JC, Brouqui P, Raoult D.
Chloroquine and hydroxychloroquine as available weapons to fight COVID-19.
Int J Antimicrob Agents. 2020;55(4):105932. doi:10.1016/j.ijantimicag.2020.105932 https://pubmed.ncbi.nlm.nih.gov/32145363/
- Raoult D, Hsueh PR, Stefani S, Rolain JM.
COVID-19 Therapeutic and Prevention.
Int J Antimicrob Agents. 2020;55(4):105937. doi:10.1016/j.ijantimicag.2020.105937 https://pubmed.ncbi.nlm.nih.gov/32151714/
- Brouqui P, Giraud-Gatineau A, Raoult D.
Remdesivir investigational trials in COVID-19: a critical reappraisal [published online ahead of print, 2020 Jun 7].
New Microbes New Infect. 2020;100707. doi:10.1016/j.nmni.2020.100707 https://pubmed.ncbi.nlm.nih.gov/32837727/
- Matthieu MILLION, Yanis ROUSSEL, Jean-Christophe LAGIER, Didier RAOULT
Re: Effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients : a systematic review and meta-analysis.
Published on-line 01/09/2020. IHU Méditerranée Infection #30. Accepted in Clinical Microbiology and Infection https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Response-to-Fiolet-et-al-Manuscript.pdf
- Wargny M, Gourdy P, Ludwig L, Seret-Bégué D, Bourron O, Darmon P, Amadou C, Pichelin M, Potier L, Thivolet C, Gautier JF, Hadjadj S, Cariou B; CORONADO investigators.
Type 1 Diabetes in People Hospitalized for COVID-19: New Insights From the CORONADO Study.
Diabetes Care. 2020 Aug 26:dc201217. doi: 10.2337/dc20-1217. Epub ahead of print. PMID: 32847826.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576421/
- Gonçalves A, Bertrand J, Ke R, Comets E, de Lamballerie X, Malvy D, Pizzorno A, Terrier O, Rosa Calatrava M, Mentré F, Smith P, Perelson AS, Guedj J.
Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load.
CPT Pharmacometrics Syst Pharmacol. 2020 Jun 18;9(9):509–14. doi: 10.1002/psp4.12543. Epub ahead of print. PMID: 32558354; PMCID: PMC7323384. https://pubmed.ncbi.nlm.nih.gov/32558354/
- Eloy P, Solas C, Touret F, Mentré F, Malvy D, de Lamballerie X, Guedj J.
Dose Rationale for Favipiravir Use in Patients Infected With SARS-CoV-2.
Clin Pharmacol Ther. 2020 Aug;108(2):188. doi: 10.1002/cpt.1877. Epub 2020 May 21. PMID: 32350860. https://pubmed.ncbi.nlm.nih.gov/32350860/
- Gautret, P., Lagier, J. C., Parola, P., Hoang, V. T., Meddeb, L., Mailhe, M., Doudier, B., Courjon, J., Giordanengo, V., Vieira, V. E., Tissot Dupont, H., Honoré, S., Colson, P., Chabrière, E., La Scola, B., Rolain, J. M., Brouqui, P., & Raoult, D. (2020).
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
International journal of antimicrobial agents, 56(1), 105949. https://doi.org/10.1016/j.ijantimicag.2020.105949
- Didier Raoult, Matthieu Million, Philippe Gautret, Jean-Christophe Lagier, Philippe Colson, Philippe Parola, and Jean-Marc Rolain.
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial : Response to David Spencer (Elsevier).
Published online 08/07/2020: https://doi.org/10.35088/bjjr-cy47
- Gautret, P., Lagier, J. C., Parola, P., Hoang, V. T., Meddeb, L., Sevestre, J., Mailhe, M., Doudier, B., Aubry, C., Amrane, S., Seng, P., Hocquart, M., Eldin, C., Finance, J., Vieira, V. E., Tissot-Dupont, H. T., Honoré, S., Stein, A., Million, M., Colson, P., … Raoult, D. (2020).
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
Travel medicine and infectious disease, 34, 101663. https://doi.org/10.1016/j.tmaid.2020.101663 https://pubmed.ncbi.nlm.nih.gov/32289548/
- Million, M., Lagier, J. C., Gautret, P., Colson, P., Fournier, P. E., Amrane, S., Hocquart, M., Mailhe, M., Esteves-Vieira, V., Doudier, B., Aubry, C., Correard, F., Giraud-Gatineau, A., Roussel, Y., Berenger, C., Cassir, N., Seng, P., Zandotti, C., Dhiver, C., Ravaux, I., … Raoult, D. (2020).
Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France.
Travel medicine and infectious disease, 35, 101738. https://doi.org/10.1016/j.tmaid.2020.101738 https://pubmed.ncbi.nlm.nih.gov/32387409/
- La Scola, B., Le Bideau, M., Andreani, J., Hoang, V. T., Grimaldier, C., Colson, P., Gautret, P., & Raoult, D. (2020)
Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 39(6), 1059–1061. https://doi.org/10.1007/s10096-020-03913-9https://pubmed.ncbi.nlm.nih.gov/32342252/
- Baron SA, Devaux C, Colson P, Raoult D, Rolain JM.
Teicoplanin: an alternative drug for the treatment of COVID-19?
Int J Antimicrob Agents. 2020;55(4):105944. doi:10.1016/j.ijantimicag.2020.105944 https://pubmed.ncbi.nlm.nih.gov/32179150/
Tran Duc Anh Ly, Didier Zanini, Vincent Laforge, Sylvie Arlotto, Stephanie Gentile, Helene Mendizabal, Michaël Finaud, David Morel, Olivier Quenette, Priscilla Malfuson-Clot-Faybesse, Alain Midejean, Phuc Le-Dinh, Gérard Daher, Berengere Labarriere, Anne-Marie Morel-Roux, Alain Coquet, Patrick Augier, Philippe Parola, Eric Chabriere, Didier Raoult, Philippe Gautret
Pattern of SARS-CoV-2 infection among dependant elderly residents living in long-term care facilities in Marseille, France, March–June 2020
International Journal of Antimicrobial Agents, Available online 13 November 2020, 106219 https://www.sciencedirect.com/science/article/pii/S0924857920304301
VIROLOGY – ISOLATION – IN VITRO TESTING
- Andreani, J., Le Bideau, M., Duflot, I., Jardot, P., Rolland, C., Boxberger, M., Wurtz, N., Rolain, J. M., Colson, P., La Scola, B., & Raoult, D. (2020).
In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect.
Microbial pathogenesis, 145, 104228. https://doi.org/10.1016/j.micpath.2020.104228https://pubmed.ncbi.nlm.nih.gov/32344177/
- Gendrot M, Andreani J, Boxberger M, Jardot P, Fonta I, Le Bideau M, Duflot I, Mosnier J, Rolland C, Bogreau H, Hutter S, La Scola B, Pradines B.
Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation.
Travel Med Infect Dis. 2020 Sep 8;37:101873. doi: 10.1016/j.tmaid.2020.101873. Epub ahead of print. PMID: 32916297; PMCID: PMC7477610. https://pubmed.ncbi.nlm.nih.gov/32916297/
- Touret F, Gilles M, Barral K, Nougairède A, van Helden J, Decroly E, de Lamballerie X, Coutard B.
In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication.
Sci Rep. 2020 Aug 4;10(1):13093. doi: 10.1038/s41598-020-70143-6. PMID: 32753646; PMCID: PMC7403393. https://pubmed.ncbi.nlm.nih.gov/32753646/
- Maisonnasse P, Guedj J, Contreras V, Behillil S, Solas C, Marlin R, Naninck T, Pizzorno A, Lemaitre J, Gonçalves A, Kahlaoui N, Terrier O, Fang RHT, Enouf V, Dereuddre-Bosquet N, Brisebarre A, Touret F, Chapon C, Hoen B, Lina B, Calatrava MR, van der Werf S, de Lamballerie X, Le Grand R.
Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates.
Nature. 2020 Sep;585(7826):584-587. doi: 10.1038/s41586-020-2558-4. Epub 2020 Jul 22. PMID: 32698191. https://pubmed.ncbi.nlm.nih.gov/32698191/
- Pastorino B, Touret F, Gilles M, de Lamballerie X, Charrel RN.
Heat Inactivation of Different Types of SARS-CoV-2 Samples: What Protocols for Biosafety, Molecular Detection and Serological Diagnostics?
2020 Jul 7;12(7):735. doi: 10.3390/v12070735. PMID: 32646015; PMCID: PMC7412566. https://pubmed.ncbi.nlm.nih.gov/32646015/
- Pastorino B, Touret F, Gilles M, Luciani L, de Lamballerie X, Charrel RN.
Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples.
2020 Jun 8;12(6):624. doi: 10.3390/v12060624. PMID: 32521706; PMCID: PMC7354533. https://pubmed.ncbi.nlm.nih.gov/32521706/
- Gendrot M, Andreani J, Jardot P, Hutter S, Delandre O, Boxberger M, Mosnier J, Le Bideau M, Duflot I, Fonta I, Rolland C, Bogreau H, La Scola B, Pradines B.
In vitro antiviral activity of doxycycline against SARS-CoV-2.
Molecules, 2020, 25 :5064. Doi: 10.3390/molecules25215064 https://pubmed.ncbi.nlm.nih.gov/33142770/
- Gendrot M, Andreani J, Duflot I, Boxberger M, Le Bideau M, Mosnier J, Jardot P, Fonta I, Rolland C, Bogreau H, Hutter S, La Scola B, Pradines B.
Methylene blue inhibits the replication of SARS-CoV-2 in vitro.
Int J Antimicrob Agents, 2020, 106202. Doi: 10.1016/j.ijantimicag.2020.106202 https://pubmed.ncbi.nlm.nih.gov/33075512/
- Gendrot M, Duflot I, Boxberger M, Delandre O, Jardot P, Le Bideau M, Andreani J, Fonta I, Mosnier J, Rolland C, Hutter S, La Scola B, Pradines B.
Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate.
Int J Infect Dis, 2020, 99 :437-440. Doi: 10.1016/j.ijid.2020.08.032 https://pubmed.ncbi.nlm.nih.gov/32805422/
GENOMICS
- Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E.
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
Antiviral Res. 2020 Apr;176:104742. doi: 10.1016/j.antiviral.2020.104742. Epub 2020 Feb 10. PMID: 32057769; PMCID: PMC7114094.
MICROSCOPY
- Francis R, Le Bideau M, Jardot P, Grimaldier C, Raoult D, Bou Khalil JY, La Scola B.
High-speed large-scale automated isolation of SARS-CoV-2 from clinical samples using miniaturized co-culture coupled to high-content screening.
Clin Microbiol Infect. 2020 Sep 23:S1198-743X(20)30570-X. doi: 10.1016/j.cmi.2020.09.018. Epub ahead of print. PMID: 32979576; PMCID: PMC7510445.
- Colson P, Lagier JC, Baudoin JP, Bou Khalil J, La Scola B, Raoult D.
Ultrarapid diagnosis, microscope imaging, genome sequencing, and culture isolation of SARS-CoV-2.
Eur J Clin Microbiol Infect Dis. 2020;39(8):1601-1603. doi:10.1007/s10096-020-03869-w https://pubmed.ncbi.nlm.nih.gov/32270412/
- Djamal Brahim Belhaouari, Anthony Fontanini, Jean-Pierre Baudoin, Gabriel Haddad, Marion Le Bideau, Jacques Yaacoub Bou Khalil, Didier Raoult and Bernard La Scola.
The strengths of scanning electron microscopy in deciphering SARS-CoV-2 infectious cycle.
Frontiers in Microbiology VOLUME=11 YEAR=2020 PAGES=2014 3389/fmicb.2020.02014 https://www.frontiersin.org/article/10.3389/fmicb.2020.02014
IMMUNOLOGY
- Bertin, D., Brodovitch, A., Beziane, A., Hug, S., Bouamri, A., Mege, J. L., & Bardin, N. (2020).
Anti-cardiolipin IgG autoantibodies are an independent risk factor of COVID-19 severity.
Arthritis & rheumatology (Hoboken, N.J.), 10.1002/art.41409. Advance online publication. https://doi.org/10.1002/art.41409https://pubmed.ncbi.nlm.nih.gov/32564467/
- Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen J, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort, Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL. Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020 Sep 24:eabd4585. doi: 10.1126/science.abd4585. Epub ahead of print. PMID: 32972996.
- Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Çölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela ŞN, Gallego CR, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-19; Biobank; COVID Human Genetic Effort; NIAID-USUHS; TAGC COVID Immunity Group, Snow AL, Dalgard CL, Milner J, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli M, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton R, Zhang SY, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science. 2020 Sep 24:eabd4570. doi: 10.1126/science.abd4570. Epub ahead of print. PMID: 32972995.
- Melenotte C, Silvin A, Goubet AG, Lahmar I, Dubuisson A, Zumla A, Raoult D, Merad M, Gachot B, Hénon C, Solary E, Fontenay M, André F, Maeurer M, Ippolito G, Piacentini M, Wang FS, Ginhoux F, Marabelle A, Kroemer G, Derosa L, Zitvogel L.
Immune responses during COVID-19 infection.
Oncoimmunology. 2020 Aug 25;9(1):1807836. doi: 10.1080/2162402X.2020.1807836. PMID: 32939324; PMCID: PMC7480812.
- Vitte J, Michel M, Mezouar S, Diallo AB, Boumaza A, Mege JL, Desnues B.
Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines.
Front Immunol. 2020 Aug 28;11:2159. doi: 10.3389/fimmu.2020.02159. PMID: 32983179; PMCID: PMC7484884.
- Vitte J, Diallo AB, Boumaza A, Lopez A, Michel M, Allardet-Servent J, Mezouar S, Sereme Y, Busnel JM, Miloud T, Malergue F, Morange PE, Halfon P, Olive D, Leone M, Mege JL.
A granulocytic signature identifies COVID-19 and its severity.
J Infect Dis. 2020 Sep 17:jiaa591. doi: 10.1093/infdis/jiaa591. Epub ahead of print. PMID: 32941618; PMCID: PMC7543529.
- Pierre-Edouard FOURNIER,
Contribution of VitaPCR SARS-CoV-2 to the emergency diagnosis of COVID-19
In press Journal of Clinical Virology.
DIAGNOSIS
- Amrane, S., Tissot-Dupont, H., Doudier, B., Eldin, C., Hocquart, M., Mailhe, M., Dudouet, P., Ormières, E., Ailhaud, L., Parola, P., Lagier, J. C., Brouqui, P., Zandotti, C., Ninove, L., Luciani, L., Boschi, C., La Scola, B., Raoult, D., Million, M., Colson, P., … Gautret, P. (2020).
Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France – January 31st to March 1st, 2020: A respiratory virus snapshot.
Travel medicine and infectious disease, 101632. Advance online publication. https://doi.org/10.1016/j.tmaid.2020.101632
- Boudjema S, Finance J, Coulibaly F, Meddeb L, Tissot-Dupont H, Michel M, Lagier JC, Million M, Radulesco T, Michel J, Brouqui P, Raoult D, Fenollar F, Parola P.
Olfactory and gustative disorders for the diagnosis of COVID-19.
Travel Med Infect Dis. 2020 Sep 6;37:101875. doi: 10.1016/j.tmaid.2020.101875. Epub ahead of print. PMID: 32898703; PMCID: PMC7474847.
- Jaafar R, Aherfi S, Wurtz N, Grimaldier C, Hoang VT, Colson P, Raoult D, La Scola B.
Correlation between 3790 qPCR positives samples and positive cell cultures including 1941 SARS-CoV-2 isolates.
Clin Infect Dis. 2020 Sep 28:ciaa1491. doi: 10.1093/cid/ciaa1491. Epub ahead of print. PMID: 32986798; PMCID: PMC7543373.
- Pezzi L, Charrel RN, Ninove L, Nougairede A, Molle G, Coutard B, Durand G, Leparc-Goffart I, de Lamballerie X, Thirion L.
Development and Evaluation of a duo SARS-CoV-2 RT-qPCR Assay Combining Two Assays Approved by the World Health Organization Targeting the Envelope and the RNA-Dependant RNA Polymerase (RdRp) Coding Regions.
Viruses. 2020 Jun 25;12(6):686. doi: 10.3390/v12060686. PMID: 32630601; PMCID: PMC7354606.
- Pastorino B, Touret F, Gilles M, de Lamballerie X, Charrel RN.
Prolonged Infectivity of SARS-CoV-2 in Fomites.
Emerg Infect Dis. 2020 Sep;26(9):2256–7. doi: 10.3201/eid2609.201788. Epub 2020 Jun 24. PMID: 32579874; PMCID: PMC7454106.
- Nathalie Wurtz, Gwilherm Penant, Priscilla Jardot, Nathalie Duclos and Bernard La Scola
Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity and differences in growth profile
European Journal of Clinical Microbiology & Infectious Diseases
EPIDEMIOLOGY
- Roussel, Y., Giraud-Gatineau, A., Jimeno, M. T., Rolain, J. M., Zandotti, C., Colson, P., & Raoult, D. (2020).
SARS-CoV-2: fear versus data.
International journal of antimicrobial agents, 55(5), 105947. https://doi.org/10.1016/j.ijantimicag.2020.105947 https://pubmed.ncbi.nlm.nih.gov/32201354/
- Giraud-Gatineau, A., Colson, P., Jimeno, M. T., Zandotti, C., Ninove, L., Boschi, C., Lagier, J. C., La Scola, B., Chaudet, H., & Raoult, D. (2020).
Comparison of mortality associated with respiratory viral infections between December 2019 and March 2020 with that of the previous year in Southeastern France.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 96, 154–156. https://doi.org/10.1016/j.ijid.2020.05.001. https://pubmed.ncbi.nlm.nih.gov/32389848/
- Colson, P., Tissot-Dupont, H., Morand, A., Boschi, C., Ninove, L., Esteves-Vieira, V., Gautret, P., Brouqui, P., Parola, P., Lagier, J. C., Zandotti, C., Million, M., La Scola, B., & Raoult, D. (2020).
Children account for a small proportion of diagnoses of SARS-CoV-2 infection and do not exhibit greater viral loads than adults.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1–5. Advance online publication. https://doi.org/10.1007/s10096-020-03900-0https://pubmed.ncbi.nlm.nih.gov/32845413/
- Colson, P., La Scola, B., Esteves-Vieira, V., Ninove, L., Zandotti, C., Jimeno, M. T., Gazin, C., Bedotto, M., Filosa, V., Giraud-Gatineau, A., Chaudet, H., Brouqui, P., Lagier, J. C., & Raoult, D. (2020).
Letter to the editor: Plenty of coronaviruses but no SARS-CoV-2.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 25(8), 2000171. https://doi.org/10.2807/1560-7917.ES.2020.25.8.2000171. https://pubmed.ncbi.nlm.nih.gov/32127122/
- Colson P, Esteves-Vieira V, Giraud-Gatineau A, Zandotti C, Filosa V, Chaudet H, Lagier JC, Raoult D.
Temporal and age distributions of SARS-CoV-2 and other coronaviruses, Southeastern France.
Int J Infect Dis. 2020 Sep 22:S1201-9712(20)32133-0. doi: 10.1016/j.ijid.2020.09.1417. Epub ahead of print. PMID: 32976991; PMCID: PMC7511210.
- Gautret P, Colson P, Lagier JC, Camoin-Jau L, Giraud-Gatineau A, Boudjema S, Finance J, Chaudet H, Raoult D.
Different pattern of the second outbreak of COVID-19 in Marseille, France.
Int J Infect Dis. 2020 Oct 7:S1201-9712(20)32208-6. doi: 10.1016/j.ijid.2020.10.005. Epub ahead of print. PMID: 33038556.
- Gallian P, Pastorino B, Morel P, Chiaroni J, Ninove L, de Lamballerie X.
Lower prevalence of antibodies neutralizing SARS-CoV-2 in group O French blood donors.
Antiviral Res. 2020 Sep;181:104880. doi: 10.1016/j.antiviral.2020.104880. Epub 2020 Jul 15. PMID: 32679056; PMCID: PMC7362788.
- Laloui R, Bakour S, Raoult D, Verger P, Sokhna C, Devaux C, Pradines B, Rolain JM.
What could explain the late emergence of COVID-19 in Africa?
New Microbes New Infect, 2020, 38 :100760. Doi: 10.1016/j.nmni.2020.100760
HUMAN AND SOCIAL SCIENCES
- Ward JK, Alleaume C, Peretti-Watel P; COCONEL Group.
The French public’s attitudes to a future COVID-19 vaccine: The politicization of a public health issue.
Social Science and Medicine, 265:113414. doi: 10.1016/j.socscimed.2020.113414.
- COCONEL Study Group.
Attitudes about COVID-19 Lockdown among General Population, France, March 2020.
Emerging Infectious Diseases (à paraître).
- Peretti-Watel P, Alleaume C, Léger D, Beck F, Verger P.
Anxiety, depression and sleep problems: a second wave of COVID-19.
General Psychiatry, 33 (5) e100299; DOI: 10.1136/gpsych-2020-100299.
- Léger D., Beck F., Fressard L., Verger P., Peretti-Watel P., and the COCONEL Group.
Poor Sleep Associated with Overuse of Media during the COVID-19 Lockdown.
Sleep doi: 10.1093/sleep/zsaa125.
- Patrick Peretti-Watel and the COCONEL Study Group.
A future vaccination campaign against COVID-19 at risk of vaccine hesitancy and politicization.
Lancet Infectious Diseases, 2020. doi: 10.1016/S1473-3099(20)30426-6.
- Beck F., Léger D., Fressard L., Peretti-Watel P., Verger P. & the COCONEL group.
Covid-19 health crisis and lockdown associated with high level of sleep complaints and hypnotic uptake at the population level.
Journal of Sleep Research. doi: 10.1111/jsr.13119.
- Lambert A, Cayouette-Remblière J, Guéraut É, Le Roux G, Bonvalet C, Girard V, Langlois L.
Le travail et ses aménagements : ce que la pandémie de covid-19a changé pour les Français,
Population & Sociétés, Numéro 579,
- Lambert A, Cayouette-Remblière J, Guéraut É, Le Roux G, Bonvalet C, Girard V, Langlois L.
Comment voisine-t-on dans la France confinée ?
Population & Sociétés, Numéro 578, juillet 2020.
COMMENTARIES – PERSPECTIVES
- Lagier, J. C., Colson, P., Tissot Dupont, H., Salomon, J., Doudier, B., Aubry, C., Gouriet, F., Baron, S., Dudouet, P., Flores, R., Ailhaud, L., Gautret, P., Parola, P., La Scola, B., Raoult, D., & Brouqui, P. (2020).
Testing the repatriated for SARS-Cov2: Should laboratory-based quarantine replace traditional quarantine?
Travel medicine and infectious disease, 34, 101624. https://doi.org/10.1016/j.tmaid.2020.101624https://pubmed.ncbi.nlm.nih.gov/32179125/
-
Christian A. Devaux, Laurence Camoin-Jau, Jean-Louis Mege, Didier Raoult (2020)
Can hydroxychloroquine be protective against COVID-19-associated thrombotic events ?
Journal of Microbiology, Immunology and Infection
https://www.sciencedirect.com/science/article/pii/S1684118221000074?via%3Dihub -
ChristianA.Devaux, LucilePinault, IkramOmarOsman, DidierRaoult (2021)
Can ACE2 Receptor Polymorphism Predict Species Susceptibility to SARS-CoV-2 ?
Frontiers in Public Health
https://www.frontiersin.org/articles/10.3389/fpubh.2020.608765/full
- Gautret P, Raoult D.
Nullane salus extra ecclesiam.
New Microbes New Infect. 2020;37:100714. doi:10.1016/j.nmni.2020.100714 https://pubmed.ncbi.nlm.nih.gov/32834899/
- Million M, Roussel Y, Raoult D.
Chloroquine and COVID-19: A western medical and scientific drift?
Eur J Intern Med. 2020;78:4-5. doi:10.1016/j.ejim.2020.06.020 https://pubmed.ncbi.nlm.nih.gov/32600860/
- Javelle E, Raoult D.
COVID-19 pandemic more than a century after the Spanish flu [published online ahead of print, 2020 Aug 11].
Lancet Infect Dis. 2020;S1473-3099(20)30650-2. doi:10.1016/S1473-3099(20)30650-2 https://pubmed.ncbi.nlm.nih.gov/32795410/
- Raoult D, Zumla A, Locatelli F, Ippolito G, Kroemer G.
Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses.
Cell Stress. 2020;4(4):66-75. Published 2020 Mar 2. doi:10.15698/cst2020.04.216 https://pubmed.ncbi.nlm.nih.gov/32292881/
- Devaux CA, Rolain JM, Raoult D.
ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome.
J Microbiol Immunol Infect. 2020;53(3):425-435. doi:10.1016/j.jmii.2020.04.015 https://pubmed.ncbi.nlm.nih.gov/32414646/
- Roussel Y, Raoult D.
Hydroxychloroquine recommendations toward the world: first evaluations.
New Microbes New Infect. 2020 Sep 22:100759. doi: 10.1016/j.nmni.2020.100759. Epub ahead of print. PMID: 32983541; PMCID: PMC7508006.
- Million, M., Chaudet, H., & Raoult, D. (2020).
Hydroxychloroquine Failure: The End does not justify the Means.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ciaa1117. Advance online publication. https://doi.org/10.1093/cid/ciaa1117https://pubmed.ncbi.nlm.nih.gov/32761148/
- Lalaoui R, Bakour S, Raoult D, Verger P, Sokhna C, Devaux C, Pradines B, Rolain JM.
What could explain the late emergence of COVID-19 in Africa?
New Microbes New Infect. 2020 Nov;38:100760. doi: 10.1016/j.nmni.2020.100760. Epub 2020 Sep 22. PMID: 32983542; PMCID: PMC7508045.
- Raoult D.
Lancet gate: a matter of fact or a matter of concern.
New Microbes New Infect. 2020 Nov;38:100758. doi: 10.1016/j.nmni.2020.100758. Epub 2020 Sep 22. PMID: 32983540; PMCID: PMC7508049.
- Million M, Roussel Y, Lagier JC, Raoult D.
Re: ‘effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients’ by Fiolet et al.
Clin Microbiol Infect. 2020 Sep 24:S1198-743X(20)30578-4. doi: 10.1016/j.cmi.2020.09.026. Epub ahead of print. PMID: 32980527.
- Touret F, de Lamballerie X.
Of chloroquine and COVID-19.
Antiviral Res. 2020 May;177:104762. doi: 10.1016/j.antiviral.2020.104762. Epub 2020 Mar 5. PMID: 32147496; PMCID: PMC7132364.
- Frutos R, Serra-Cobo J, Chen T, Devaux CA.
COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans.
Infect Genet Evol. 2020 Oct;84:104493. doi: 10.1016/j.meegid.2020.104493. Epub 2020 Aug 5. PMID: 32768565; PMCID: PMC7405773.
- Frutos R, Lopez Roig M, Serra-Cobo J, Devaux CA.
COVID-19: The Conjunction of Events Leading to the Coronavirus Pandemic and Lessons to Learn for Future Threats.
Front Med (Lausanne). 2020 May 12;7:223. doi: 10.3389/fmed.2020.00223. PMID: 32574324; PMCID: PMC7235412.
- Devaux CA, Rolain JM, Colson P, Raoult D.
New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
Int J Antimicrob Agents. 2020;55(5):105938. doi:10.1016/j.ijantimicag.2020.105938 https://pubmed.ncbi.nlm.nih.gov/32171740/
- Raoult D.
Rational for meta-analysis and randomized treatment: the COVID-19 example.
Clin Microbiol Infect. 2020 Oct 21:S1198-743X(20)30643-1. doi: 10.1016/j.cmi.2020.10.012. Epub ahead of print. PMID: 33098998.
- Roussel Y, Million M, Chabriere E, Lagier JC, Raoult D.
Be careful with Big Data: Re-analysis of Patient Characteristics and Outcomes of 11,721 Patients with COVID19 Hospitalized Across the United States.
Clin Infect Dis. 2020 Oct 22:ciaa1618. doi: 10.1093/cid/ciaa1618. Epub ahead of print. PMID: 33086376.
- Devaux C.
Are ACE inhibitors and ARBs more beneficial than harmful in the treatment of severe COVID-19 disease?
J. Cardiovascular Med. Cardio. : 7(2): 101-103. DOI: https://dx.doi.org/10.17352/2455-2976.000122
- Gendrot M, Javelle E, Clerc A, Savini H, Pradines B.
Chloroquine as a prophylactic agent against COVID-19?
Int J Antimicrob Agents, 2020, 55 :105980. Doi: 10.1016/j.ijantimicag.2020.105980
NUMÉRO SPÉCIAL IHU
Version 1 du 8 février 2021
Two-millennia fighting against port-imported epidemics, Marseille
Barbieri, R, Colson, P., Raoult, D., Drancourt, M
Version 1 du 8 février 2021
What neo semeiology brings to the care of patient with COVID-19
Philippe Brouqui MD, PhD, Carole Eldin MD, PhD, Sophia Boudjema RN PhD & Didier Raoult MD PhD
Link to the article
BROUQUI Neosemiology Table
BROUQUI Neosemiology Panel
Brouqui Neosemiology Figure
Version 1 du 8 février 2021
Consequences of the COVID-19 outbreak on the diversity of non-viral infectious agents and the evolution of antibiotic resistance by using a syndromic surveillance based on laboratory data at the IHU Méditerranée Infection, Marseille, France
Lancei KABA, Audrey GIRAUD-GATINEAU, Marie-Thérèse JIMENO, Jean-Marc ROLAIN, Philippe COLSON, Didier RAOULT, Hervé CHAUDET
Version 1 du 8 février 2021
Epidemiological surveillance of respiratory viral infections at IHU Méditerranée Infection and its application to SARS-CoV-2
Philippe COLSON, Audrey GIRAUD-GATINEAU, Pierre-Edouard FOURNIER, Laetitia NINOVE, Christine ZANDOTTI, Marie-Thérèse JIMENO, Céline BOSCHI, Léa LUCIANI, Lancei KABA, Philippe PAROLA, Stéphane RANQUE, Jean-Marc ROLAIN, Philippe GAUTRET, Michel DRANCOURT, Jean-Christophe LAGIER, Bernard LA SCOLA, Hervé CHAUDET, Didier RAOULT
Version 1 du 8 février 2021
Severity of COVID-19 infection and different SARS-CoV-2 variants: current evidence
Thi Loi Dao, Van Thuan Hoang, Philippe Colson, Jean Christophe Lagier, Didier Raoult , Anthony Levasseur , Philippe Gautret, Matthieu Million
Link to the article
Review Covid variant
Cover_Letter
Figures
Version 1 du 8 février 2021
Point-of-care diagnosis of COVID-19 at IHU Méditerranée Infection, Marseille, France
A. Bouam, M. Boualam, P-Y. Levy, S. Honoré, B. La Scola, P-E. Fournier, D. Raoult, M. Drancourt,
Link to the article
IHU_Bouam_Drancourt_Jan2021vD
Supplementary tables
Figures
SupplFigures
Version 1 du 8 février 2021
Contagion management at the Mediterranée Infection University Hospital Institute
Pierre-Edouard FOURNIER, Sophie EDOUARD, Nathalie WURTZ , Justine RACLOT, Marion BECHET, Christine ZANDOTTI, Véronique FILOSA, Didier RAOULT, Florence FENOLLAR
Version 1 du 8 février 2021
Non-radiating and low-radiating imaging for diagnosis and management of COVID-19 pneumonia
Julie Finance, Laurent Zieleskewicz, Paul Habert , Alexis Jacquier, Philippe Parola, Alain Boussuges , Fabienne Bregeon , Carole Eldin
Version 1 du 8 février 2021
In vitro Evaluation of the Antiviral Activity of Repurposable Drugs against SARS-CoV- 2 : Methylene Blue
Mathieu Gendrot, Priscilla Jardot, Océane Delandre, Manon Boxberger, Julien Andreani, Isabelle Duflot, Marion Le Bideau, Joel Mosnier, Isabelle Fonta, Sébastien Hutter, Bernard La Scola and Bruno Pradines
Version 1 du 8 février 2021
Genome sequence analysis enabled deciphering the atypical evolution of COVID-19 epidemics in Marseille, France
Pierre-Edouard FOURNIER, Philippe COLSON, Anthony LEVASSEUR, Philippe GAUTRET, Marielle BEDOTTO, Véronique FILOSA, Jeremy DELERCE, Ludivine BRECHARD, Jean-Christophe LAGIER, Hervé CHAUDET, Florence FENOLLAR, Didier RAOULT
Link to the article
SUPPLEMENTARY MATERIAL 04-01-2020
Cover letter
Figures
Version 1 du 8 février 2021
Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates
Céline Boschi, Marion Le Bideau , Julien Andreani, Sarah Aherfi, Priscilla Jardot, Jeremy Delerce, Mathieu Gendrot, Bruno Pradines, Philippe Colson, Didier Raoult, Anthony Levasseur, Bernard La Scola
Link to the article
CoverLetter
Supplementary table 1
Figures
Article Boschi et al
Version 1 du 8 février 2021
Evolution of the management of COVID-19
Jean-Christophe Lagier, Matthieu Million, Laurence Camoin-Jau, Carole Eldin, Grégory Dubourg, Hervé Tissot-Dupont, Didier Raoult, Philippe Brouqui and Philippe Parola
Version 1 du 8 février 2021
Predictive Factors of Clinical Assays during COVID-19
Matthieu MILLION, Pierre DUDOUET, Eric CHABRIERE, Sébastien CORTAREDONA, Philippe BROUQUI, Didier RAOULT
Link to the article
Cover letter
Figures
Supplementary data
Supplementary file
Version 1 du 8 février 2021
COVID-19 in Africa : What else ?
Cheikh Sokhna, Souleymane Brah, Abdoulaye Djimde, Nadjet Mouffok, Majida Zahraoui, Ali Ould Mohamed Salem Boukhary, Idir Bitam, Badara Cisse, Mahamadou Ali Thera, Jean-Bernard Lekana-Douki, Eric Adehossi, Moussa Seydi, Jean Akiana, Jaafar Heikel, Jean-Christophe Lagier, Souleymane Mboup, Jean-Jacques Mouyembe-Tamfum, Philippe Parola
Version 1 du 8 février 2021
New Institute to fight threats: the COVID-19 paradigm
Brouqui P., Drancourt M., Raoult D
Link to the article
Table 1
Organigramme
Fig1
CL_IHU_Raoult_Jan2021vD
Version 1 du 8 février 2021
Impact of COVID-19 over Infectious Diseases publications, 2020
Roussel, Y., Ouanezar, A., Grine, G.
Version 1 du 8 février 2021
How is built the “legitimate information”on the Covid crisis
Laurent MUCCHIELLI
CLINICAL OBSERVATIONAL STUDIES AND COHORTS
Version 1 du 22 février 2021
Rapid isothermal amplification detection of buccal SARS-CoV-2 for ambulatory screening of COVID-19
Bouam, A., Vincent, J.J., Le Glass, E., Almeras, L., Tissot-Dupont, H., Lagier, J.-C., Fournier, P.-E., Raoult, D., Drancourt, M.
Version 1 du 18 février 2021
High-flow oxygen therapy in elderly patients infected with SARS-CoV2 with a contraindication for transfer to an intensive care unit
Jean-Christophe Lagier, Sophie Amrane, Morgane Mailhe, Marc Gainnier, Sylvie Arlotto, Stéphanie Gentile and Didier Raoult
Version 1 du 15 février 2021
Immature neutrophils and high anti-SARS-CoV-2 IgG levels are hallmarks of severe and critical COVID-19 infection
C. Melenotte, JC. Lagier, M. Million, M. Gainnier, S. Edouard, L. Zitvogel, P. Colson, JL Mège, P. Parola, M. Drancourt, D. Raoult
Version 1 du 15 février 2021
FDG-PET/CT revealing aortic hypermetabolism in patients with chest pain after COVID-19: a retrospective study
Pierre Dudouet, Serge Cammilleri, Alexis Jacquier, Eric Guedj, Didier Raoult, Carole Eldin
Version 1 du 11 février 2021
COVID-19 re-infection
Philippe Brouqui, Philippe Colson, Cléa Melenotte, Linda Houhamdi, Marielle Bedotto, Christian Devaux, Philipe Gautret, Matthieu Million, Philippe Parola, Didier Stoupan, Bernard La Scola, Jean-Christophe Lagier, Didier Raoult
Version 1 du 8 janvier 2021
Isolation of viable SARS-CoV-2 in feces suggesting possible fecal transmission of COVID-19
Julie Dergham, Jeremy Delerce, Marielle Bedotto, Bernard La Scola, Valérie Moal
Version 1 du 28 janvier 2021
Predictive Factors of Clinical Assays during COVID-19
Matthieu MILLION, Pierre DUDOUET, Eric CHABRIERE, Sébastien CORTAREDONA, Philippe BROUQUI, Didier RAOULT
Link to the article
Supplementary data
Supplementary file
Figure 1
Figure 2
Version 1 du 24 novembre 2020
Re: Covid-19: politicisation, “corruption,” and suppression of science
Matthieu MILLION, Didier RAOULT
Version 1 du 13 Mai 2020
Screening of SARS-CoV-2 among homeless people, asylum-seekers and other people living in precarious conditions in Marseille, France, March–April 2020.
Tran Duc Anh Ly, Van Thuan Hoang, Ndiaw Goumballa, Meriem Louni, Naomie Canard, Thi Loi Dao, Hacene Medkour, Audrey Borg, Kevin Bardy, Véra EstevesVieira, Véronique Filosa, Bernard Davoust, Oleg Mediannikov, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret
Version 1 du 08 Juin 2020
Adjusting series of patients for trial comparisons for COVID-19 treatments
Audrey GIRAUD-GATINEAU, Jean-Christophe LAGIER, Yolande OBADIA, Hervé CHAUDET, Didier RAOULT
Version 1 du 22 avril 2020
Response to Magagnoli, MedRxiv, 2020
Matthieu MILLION, Yanis ROUSSEL, Didier RAOULT
Version 1 du 22 avril 2020
Combination of hydroxychloroquine plus azithromycin as potential treatment for COVID 19 patients: pharmacology, safety profile, drug interactions and management of toxicity.
Guillaume Hache, Jean Marc Rolain, Philippe Gautret, JeanClaude Deharo, Philippe Brouqui, Didier Raoult, Stéphane Honoré
Version 1 du 24 septembre 2020
Hydroxychloroquine and Azithromycin as a Treatment of COVID-19: Results of an Open-Label Non-Randomized Clinical Trial: Response to criticisms
Didier Raoult, Matthieu Million, Jean-Christophe Lagier, Philippe Colson, Philippe Parola, Jean-Marc Rolain, Philippe Gautret
Version 1 du 1er septembre 2020
Re: Effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients : a systematic review and meta-analysis
Matthieu MILLION, Yanis ROUSSEL, Jean-Christophe LAGIER, Didier RAOULT
GENOMICS
Version 1 du 20 février 2021
Global discrepancies between numbers of available SARS-CoV-2 genomes and human 6 development indexes at country scales
Philippe COLSON, Didier RAOULT
Version 1 du 15 février 2021
LamPORE SARS-CoV-2 diagnosis and genotyping: a preliminary report
Morsli, M. Anani, H., Bréchard, L., Delerce, J., Bedotto, M., Fournier, P.-E., Drancourt, M.
Version 1 du 12 février 2021
Implementation of an in-house real-time reverse transcription-PCR assay to detect the emerging SARS-CoV-2 N501Y variants
Marielle BEDOTTO, Pierre-Edouard FOURNIER, Linda HOUHAMDI, Philippe COLSON, Didier RAOULT
DOI : https://doi.org/10.1101/2021.02.03.21250661
Version 1 du 8 février 2021
Viral RNA in city wastewater as a key indicator of COVID-19 recrudescence and containment measures effectiveness
Nathalie Wurtz, Alexandre Lacoste, Priscilla Jardot, Alain Delache, Xavier Fontaine, Maxime Verlande, Alexandre Annessi, Audrey Giraud-Gatineau, Pierre-Edouard Fournier, Patrick Augier, Bernard La Scola
Version 1 du 8 février 2021
Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates
Celine Boschi, Marion Le Bideau, Julien Andreani, Sarah Aherfi, Priscilla Jardot, Jeremy Delerce, Mathieu Gendrot, Bruno Pradines, Philippe Colson, Didier Raoult, Anthony Levasseur, Bernard La Scola
Version 1 du 2 février 2021
Genome sequence analysis enabled deciphering the atypical evolution of COVID-19 epidemics in Marseille, France
Pierre-Edouard FOURNIER, Philippe COLSON, Anthony LEVASSEUR, Philippe GAUTRET, Marielle BEDOTTO, Véronique FILOSA, Jeremy DELERCE, Ludivine BRECHARD, Jean-Christophe LAGIER, Hervé CHAUDET, Florence FENOLLAR, Didier RAOULT
Version 1 du 27 janvier 2021
Emergence and outcome of the SARS-CoV-2 “Marseille-4” variant
Pierre-Edouard FOURNIER, Philippe COLSON, Anthony LEVASSEUR, Christian DEVAUX, Philippe GAUTRET, Marielle BEDOTTO, Jeremy DELERCE, Ludivine BRECHARD, Lucile PINAULT, Jean-Christophe LAGIER, Florence FENOLLAR, Didier RAOULT
Version 1 du 07 septembre 2020
Dramatic increase in the SARS-CoV-2 mutation rate and low mortality rate during the second epidemic in summer in Marseille
Philippe COLSON, Anthony LEVASSEUR, Jeremy DELERCE, Hervé CHAUDET, Vincent BOSSI, Mariem BEN KHEDHER, Pierre-Edouard FOURNIER, Jean-Christophe LAGIER, Didier RAOULT
IMMUNOLOGY
Version 1 du 12 février 2021
Automated Western immunoblotting detection of anti-SARS-CoV-2 serum antibodies
Sophie Edouard, Rita Jaafar, Nicolas Orain, Philippe Parola, Philippe Colson, Bernard La Scola, Pierre-Edouard Fournier, Didier Raoult, Michel Drancourt
Version 1 du 08 septembre 2020
High prevalence of Lupus Anticoagulant in Ambulatory COVID-19 patients: interest of Hydroxychloroquine ?
Laurence Camoin-Jau, Philippe Gautret, Philippe Colson, Jean Christophe Lagier, Hervé Tissot-Dupont, Matthieu Million, Audrey Giraud-Gatineau, Sophia Boudjema, Hervé Chaudet, Didier Raoult
Version 1 du 14 septembre 2020
Daytime variation in SARS-CoV-2 infection and cytokine production
Aissatou Bailo Diallo, Laetitia Gay, Benjamin Coiffard, Marc Leone, Soraya Mezouar, Jean-Louis Mège
Link to the article : https://www.biorxiv.org/content/10.1101/2020.09.09.290718v1
Version 1 du 21 septembre 2020
Monocytes and macrophages, targets of SARS-CoV-2: the clue for Covid-19 immunoparalysis
Asma Boumaza, Laetitia Gay, Soraya Mezouar, Aïssatou Bailo Diallo, Moise Michel1,2, Benoit Desnues1,2, Didier Raoult1,2, Bernard La Scola1,2, Philippe Halfon, Joana Vitte, Daniel Olive and Jean-Louis Mege
DIAGNOSTIC
Version 1 du 12 février 2021
Pipeline for drug repurposing of FDA-approved drugs against SARS-CoV-1 and SARS-CoV-2
Sarah Aherfi, Bruno Pradines, Christian Devaux, Stéphane Honore, Philippe Colson, Bernard La Scola, Didier Raoult
Version 1 du 3 février 2021
Cyclosporin A: a repurposable drug in the treatment of COVID-19 ?
Christian A. DEVAUX, Cléa MELENOTTE, Marie-Dominique PIERCECCHI-MARTI, Clémence DELTEIL, and Didier RAOULT
Version 2 du 24 septembre 2020
Evaluating the serological status of COVID-19 patients using an indirect immunofluorescent assay, France
S. Edouard, P. Colson, C. Melenotte, F. De Pinto, L. Thomas, B. La Scola, M. Million, H. Tissot-Dupont, P. Gautret, A. Stein, P. Brouqui, P. Parola, J-C Lagier, D. Raoult, M. Drancourt
Version 1 du 12 octobre 2020
Living SARS-CoV-2 in feces suggesting possible fecal-oral contamination
Julie Dergham, Jeremy Delerce, Marielle Bedotto, Bernard La Scola, Valérie Moal
ÉPIDÉMIOLOGIE
Version 1 du 18 février 2021
Life-years lost by COVID-19 patients in public hospitals of Marseille (APHM- South-Eastern France): a limited death toll
Sylvie Arlotto, Alice Gares, Audrey Giraud-Gatineau, Jean-Christophe Lagier, Marie Thèrese Jimeno, Patrick Peretti-Watel, Matthieu Million,Philippe Parola, Philippe Brouqui, Didier Raoult, Stephanie Gentile
Version 1 du 12 février 2021
Evaluation of strategies to fight COVID-19: The French paradigm
Audrey GIRAUD-GATINEAU; Philippe GAUTRET; Philippe COLSON; Hervé CHAUDET; Didier RAOULT
Version 1 du 10 février 2021
The need for early management in patients with COVID-19
Audrey Giraud-Gatineau; Sébastien Cortaredona; Jean-Christophe Lagier; Matthieu Million; Philippe Brouqui; Yolande Obadia; Patrick Peretti-Watel; Didier Raoult; Stéphanie Gentile
Version 1 du 8 février 2021
Mink, SARS-CoV-2, and the human-animal interface
F. Fenollar, O. Mediannikov, M. Maurin, C. Devaux, P. Colson, A. Levasseur, PE. Fournier, D. Raoult
Version 1 du 9 février 2021
Epidemiological surveillance of respiratory viral infections at IHU Méditerranée Infection and its application to SARS-CoV-2
Philippe COLSON, Audrey GIRAUD-GATINEAU & Didier RAOU
Version 1 du 10 Juin 2020
Open screening of SARS-CoV-2 infections in the pediatric population in Marseille, Southern France
Aurélie Morand, PhD, MD1,2*, Tatiana Matteudi1, Alexandre Fabre, PhD, MD3,4, Philippe Minodier, MD5, Emmanuelle Bosdure, MD1, Léa Luciani, PharmD2, Jean-Christophe Dubus, PhD, MD1,6, Matthieu Million, PhD, MD2,6, Hervé Tissot-Dupont, MD2,6, Bernard La Scola, PhD, MD2,6, Philippe Colson, PhD, PharmD2,6, Didier Raoult, PhD, MD2,6, Brigitte Chabrol, PhD, MD1
In this cohort study we reported the first 302 pediatric SARS-CoV-2-positive patients in Marseille, mainly diagnosed thanks to open screening platform (80%).
Version 1 du 07 septembre 2020
Temporal and age distributions of SARS-CoV-2 and other coronaviruses, Southeastern France
Philippe COLSON, Vera ESTEVES-VIEIRA, Audrey GIRAUD-GATINEAU, Christine ZANDOTTI, Véronique FILOSA, Hervé CHAUDET, Jean-Christophe LAGIER, Didier RAOULT
Version 1 du 1er septembre 2020
Differences pattern of the second outbreak of COVID-19 in Marseille, France
Philippe Gautret, Philippe Colson, Jean Christophe Lagier, Laurence Camoin-Jau, Audrey Giraud-Gatineau, Sophia Boudjema, Hervé Chaude, Didier Raoult
Version 1 du 07 septembre 2020
Dramatic increase in the SARS-CoV-2 mutation rate and low mortality rate during the second epidemic in summer in Marseille
Philippe COLSON, Anthony LEVASSEUR, Jeremy DELERCE, Hervé CHAUDET, Vincent BOSSI, Mariem BEN KHEDHER, Pierre-Edouard FOURNIER, Jean-Christophe LAGIER, Didier RAOULT
Version 2 du 21 août 2020
Pattern of SARS-CoV-2 infection among dependant elderly residents living in retirement homes in Marseille, France, March-June 2020
Tran Duc Anh Ly, Didier Zanini, Vincent Laforge, Sylvie Arlotto, Stephanie Gentile, Helene Mendizabal, Michaël Finaud, David Morel, Olivier Quenette, Priscilla Malfuson-Clot-Faybesse, Alain Midejean, Phuc Le-Dinh, Gérard Daher, Berengere Labarriere, Anne-Marie Morel-Roux, Alain Coquet, Patrick Augier, Philippe Parola, Eric Chabriere, Didier Raoult, Philippe Gautret
Version 2 du 30 mars 2020
Decreased mortality associated with respiratory viral infections between December 2019 and March 2020 compared to previous year, Southeast France
Audrey GIRAUD-GATINEAU, Philippe COLSON, Marie-Thérèse JIMENO, Christine ZANDOTTI, Laetitia NINOVE, Céline BOSCHI, JeanChristophe LAGIER, Bernard LA SCOLA, Hervé CHAUDET, Didier RAOULT
COMMENTARIES – PERSPECTIVES
1er mars 2021
Do remdesivir and plasma therapy favor long-term SARS-CoV-2 infection and mutations in immunocompromised patients?
Philippe Gautret, Jean Christophe Lagier, Philippe Colson, Didier Raoult
16 février 2021
Does remdesivir favor long-term SARS-CoV-2 infection and mutations in immunocompromised patients ?
Philippe Gautret, Jean Christophe Lagier, Philippe Colson, Didier Raoult
16 février 2021
Who would accept a randomized trial in the context of covid-19 ?
Hervé Tissot-Dupont, Didier Raoult
12 février 2021
Opinion for the British Medical Journal – The War Against Chloroquine
Philippe Gautret, Didier Raoult
10 février 2021
Remdesivir could promote the occurrence of SARS-CoV-2 variants
Philippe COLSON, Christian A. DEVAUX, Didier RAOULT
Version 1 du 21 août 2020
Quousque tandem abutere, patientia nostra – Article soumis et rejeté par The New England Journal of Medecine
Didier Raoult, M.D, Ph.D., Jean-Christophe Lagier M.D, Ph.D., Philippe Brouqui, M.D., Ph.D., Philippe Parola, M.D, Ph.D.
Version 1 du 30 juin 2020
Does IHU Mediterranean Infection influence Gilead stock price ?
Eric Chabrière
Version 1 du 30 juin 2020
Hydroxychloroquine recommendations toward the world : first evaluations
Yanis ROUSSEL, Didier RAOULT
Version 1 du 30 juin 2020
Remdesivir investigational trials in COVID-19: a critical reappraisal
P Brouqui, A Giraud-Gatineau & D Raoult
Lire l’article
Lettre à l’éditeur
Answer to reviewer’s comment and editor
The Lancet Covid-19 Therapy Study: another miss-out
(On Covid-19 and Hydroxychloroquine The Lancet – SCANDAL)
Dragan Pavlovic
Version 2 du 18 Juin 2020
Why randomised Controlled Trials during epidemic
Philippe Brouqui, Didier Raoult
In epidemics there is an urgent need for new knowledge on drug efficacy to help policymakers fight the crisis. Yet the best research methodology to do this is a matter of debate, write Philippe Brouqui and Didier Raoult.
SUBMITTED
Omar Osman I et al.
Expression of ACE2 receptor, soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin (1-7), is modulated in COVID-19 patients
JCI: submitted
Frutos R et al.
Understanding the origin of COVID-19 requires to change the paradigm for zoonotic emergence
Trends Microbiol.: submitted.
Devaux C.
Can ACE2 receptor polymorphism predict species susceptibility to SARS-CoV-2 ?
Front public health: submitted/research square DOI: 10.21203/rs.3.rs-25753/v1