Le site des publications & des preprint de l’IHU sur le COVID-19
Compte-tenu de la vitesse d’évolution de l’épidémie et des besoins de renseignements permanents pour la communauté scientifique, associé à la difficulté des déplacements, la fondation a décidé de mettre online les articles soumis (preprint), comme ont déjà commencé à le faire les sites mais qui dans la situation actuelle ont des délais trop importants pour être compatibles avec les besoins de rapidité que nous avons.
Dès aujourd’hui, toutes les publications que nous soumettrons seront mises en preprint sur notre site et seront remplacées par un lien vers une publication scientifique officielle, dès que ces articles seront acceptés et dans leur forme définitive.
Nous espérons que ceci permettra aux scientifiques du monde entier de suivre les travaux que nous menons dans cette situation épidémique.
The IHU publication and pre-publication site on COVID-19
Given the speed of evolution of the epidemic and the permanent information needs of the scientific community, combined with the difficulty of travel, the foundation has decided to put online the submitted articles (preprint), as have already started to do the sites but which in the current situation have deadlines too important to be compatible with the need for speed that we have.
As of today, all the publications that we will submit will be put in preprint on our site and will be replaced by a link to an official scientific publication, as soon as these articles are accepted and in their final form.
We hope that this will allow scientists around the world to follow our work in this epidemic situation.
Clinical observational studies and Cohorts
- Million M, Lagier JC, Tissot-Dupont H, Ravaux I, Dhiver C, Tomei C, Cassir N, Delorme L, Cortaredona S, Amrane S, Aubry C, Bendamardji K, Berenger C, Doudier B, Edouard S, Hocquart M, Mailhe M, Porcheto C, Seng P, Triquet C, Gentile S, Jouve E, Giraud-Gatineau A, Chaudet H, Camoin-Jau L, Colson P, Gautret P, Fournier PE, Maille B, Deharo JC, Habert P, Gaubert JY, Jacquier A, Honore S, Guillon-Lorvellec K, Obadia Y, Parola P, Brouqui P, Raoult D.
Early combination therapy with hydroxychloroquine and azithromycin reduces mortality in 10,429 COVID-19 outpatients.
Rev Cardiovasc Med. 2021 Sep 24;22(3):1063-1072. doi: 10.31083/j.rcm2203116. PMID: 34565108.
Link : https://www.imrpress.com/journal/RCM/22/3/10.31083/j.rcm2203116/htm
- Lagier JC, Million M, Cortaredona S, Delorme L, Colson P, Fournier PE, Brouqui P, Raoult D, Parola P.
Outcomes of 2111 COVID-19 Hospitalized Patients Treated with Hydroxychloroquine/Azithromycin and Other Regimens in Marseille, France, 2020: A Monocentric Retrospective Analysis.
Ther Clin Risk Manag. 2022;18:603-617
https://doi.org/10.2147/TCRM.S364022
Link: https://www.dovepress.com/articles.php?article_id=75645
- Bastard P, Gervais A, Le Voyer T, et al.
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
Sci Immunol. 2021;6(62):eabl4340. doi:10.1126/sciimmunol.abl4340
- Asano T, Boisson B, Onodi F, et al.
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.
Sci Immunol. 2021;6(62):eabl4348. doi:10.1126/sciimmunol.abl4348
- Hoang VT, Colson P, Levasseur A, et al.
Clinical outcomes in patients infected with different SARS-CoV-2 variants at one hospital during three phases of the COVID-19 epidemic in Marseille, France. Infect Genet Evol. 2021;95:105092. doi:10.1016/j.meegid.2021.105092
- Arlotto S, Garès A, Giraud-Gatineau A, et al.
Life-years lost by COVID-19 patients in public hospitals of Marseille (APHM-South-Eastern France): a limited death toll: a retrospective analysis.
BMJ Open. 2021;11(12):e049475. Published 2021 Dec 30. doi:10.1136/bmjopen-2021-049475
- Nguyen NN, Hoang VT, Dao TL, et al.
Long-term persistence of symptoms of dyspnoea in COVID-19 patients.
Int J Infect Dis. 2022;115:17-23. doi:10.1016/j.ijid.2021.11.035
- Manry J, Bastard P, Gervais A, et al.
The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies.
Preprint. Res Sq. 2022;rs.3.rs-1225906. Published 2022 Jan 14. doi:10.21203/rs.3.rs-1225906/v1
- Van-Thuan Hoang, Philippe Colson, Anthony Levasseur, Jérémy Delerce, Jean-Christophe Lagier, Philippe Parola, Matthieu Million, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret
Clinical outcomes in patients infected with different SARS-CoV-2 variants at one hospital during three phases of the COVID-19 epidemic in Marseille, France
Link : https://www.sciencedirect.com/science/article/pii/S1567134821003907?dgcid=coauthor
- Jean-Christophe Lagier, Sophie Amrane, Morgane Mailhe, Marc Gainnier, Sylvie Arlotto, Stéphanie Gentile and Didier Raoult
High-flow oxygen therapy in elderly patients infected with SARS-CoV2 with a contraindication for transfer to an intensive care unit
Link : https://www.ijidonline.com/article/S1201-9712(21)00305-2/fulltext
- Bouam, A., Vincent, J.J., Le Glass, E., Almeras, L., Tissot-Dupont, H., Lagier, J.-C., Fournier, P.-E., Raoult, D., Drancourt, M.
Rapid isothermal amplification detection of buccal SARS-CoV-2 for ambulatory screening of COVID-19
J. Clin. Med.2021, 10(12), 2643
Abstract: https://www.mdpi.com/2077-0383/10/12/2643
PDF Version: https://www.mdpi.com/2077-0383/10/12/2643/pdf
- Julie Finance, Laurent Zieleskewicz, Paul Habert , Alexis Jacquier, Philippe Parola, Alain Boussuges , Fabienne Bregeon , Carole Eldin
Non-radiating and low-radiating imaging for diagnosis and management of COVID-19 pneumonia
J. Clin. Med. 2021, 10, 2196. https://doi.org/10.3390/jcm10102196 : https://www.mdpi.com/2077-0383/10/10/2196/pdf
- Lagier, J. C., Million, M., Gautret, P., Colson, P., Cortaredona, S., Giraud-Gatineau, A., Honoré, S., Gaubert, J. Y., Fournier, P. E., Tissot-Dupont, H., Chabrière, E., Stein, A., Deharo, J. C., Fenollar, F., Rolain, J. M., Obadia, Y., Jacquier, A., La Scola, B., Brouqui, P., Drancourt, M., … IHU COVID-19 Task force (2020).
Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis.
Travel medicine and infectious disease, 36, 101791. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315163/
- Philippe Brouqui, Philippe Colson, Cléa Melenotte, Linda Houhamdi, Marielle Bedotto, Christian Devaux, Philipe Gautret, Matthieu Million, Philippe Parola, Didier Stoupan, Bernard La Scola, Jean-Christophe Lagier, Didier Raoult
COVID-19 re-infection
European Society for Clinical Investigation Journal Foundation – https://onlinelibrary.wiley.com/doi/10.1111/eci.13537
- Morand, A., Roquelaure, B., Colson, P., Amrane, S., Bosdure, E., Raoult, D., Lagier, J. C., & Fabre, A. (2020).
Child with liver transplant recovers from COVID-19 infection.
A case report. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 27(5), 275–276. https://doi.org/10.1016/j.arcped.2020.05.004 https://pubmed.ncbi.nlm.nih.gov/32402433/
- Amatore, F., Macagno, N., Mailhe, M., Demarez, B., Gaudy-Marqueste, C., Grob, J. J., Raoult, D., Brouqui, P., & Richard, M. A. (2020).
SARS-CoV-2 infection presenting as a febrile rash.
Journal of the European Academy of Dermatology and Venereology : JEADV, 34(7), e304–e306. https://doi.org/10.1111/jdv.16528 https://pubmed.ncbi.nlm.nih.gov/32330336/
- Aherfi S, Gautret P, Chaudet H, Raoult D, La Scola B.
Clusters of COVID-19 associated with Purim celebration in the Jewish community in Marseille, France, March 2020 [published online ahead of print, 2020 Aug 20].
Int J Infect Dis. 2020;S1201-9712(20)30679-2. doi:10.1016/j.ijid.2020.08.049 https://pubmed.ncbi.nlm.nih.gov/32829043/
- Guedj, E., Million, M., Dudouet, P., Tissot-Dupont, H., Bregeon, F., Cammilleri, S., & Raoult, D. (2020).
18F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders?
European journal of nuclear medicine and molecular imaging, 1–4. Advance online publication. https://doi.org/10.1007/s00259-020-04973-xhttps://pubmed.ncbi.nlm.nih.gov/32728799/
- Colson P, Rolain JM, Raoult D.
Chloroquine for the 2019 novel coronavirus SARS-CoV-2.
Int J Antimicrob Agents. 2020;55(3):105923. doi:10.1016/j.ijantimicag.2020.105923 https://pubmed.ncbi.nlm.nih.gov/32070753/
- Colson P, Rolain JM, Lagier JC, Brouqui P, Raoult D.
Chloroquine and hydroxychloroquine as available weapons to fight COVID-19.
Int J Antimicrob Agents. 2020;55(4):105932. doi:10.1016/j.ijantimicag.2020.105932 https://pubmed.ncbi.nlm.nih.gov/32145363/
- Raoult D, Hsueh PR, Stefani S, Rolain JM.
COVID-19 Therapeutic and Prevention.
Int J Antimicrob Agents. 2020;55(4):105937. doi:10.1016/j.ijantimicag.2020.105937 https://pubmed.ncbi.nlm.nih.gov/32151714/
- Brouqui P, Giraud-Gatineau A, Raoult D.
Remdesivir investigational trials in COVID-19: a critical reappraisal [published online ahead of print, 2020 Jun 7].
New Microbes New Infect. 2020;100707. doi:10.1016/j.nmni.2020.100707 https://pubmed.ncbi.nlm.nih.gov/32837727/
- Matthieu MILLION, Yanis ROUSSEL, Jean-Christophe LAGIER, Didier RAOULT
Re: Effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients : a systematic review and meta-analysis.
Published on-line 01/09/2020. IHU Méditerranée Infection #30. Accepted in Clinical Microbiology and Infection https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Response-to-Fiolet-et-al-Manuscript.pdf
- Wargny M, Gourdy P, Ludwig L, Seret-Bégué D, Bourron O, Darmon P, Amadou C, Pichelin M, Potier L, Thivolet C, Gautier JF, Hadjadj S, Cariou B; CORONADO investigators.
Type 1 Diabetes in People Hospitalized for COVID-19: New Insights From the CORONADO Study.
Diabetes Care. 2020 Aug 26:dc201217. doi: 10.2337/dc20-1217. Epub ahead of print. PMID: 32847826.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576421/
- Gonçalves A, Bertrand J, Ke R, Comets E, de Lamballerie X, Malvy D, Pizzorno A, Terrier O, Rosa Calatrava M, Mentré F, Smith P, Perelson AS, Guedj J.
Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load.
CPT Pharmacometrics Syst Pharmacol. 2020 Jun 18;9(9):509–14. doi: 10.1002/psp4.12543. Epub ahead of print. PMID: 32558354; PMCID: PMC7323384. https://pubmed.ncbi.nlm.nih.gov/32558354/
- Eloy P, Solas C, Touret F, Mentré F, Malvy D, de Lamballerie X, Guedj J.
Dose Rationale for Favipiravir Use in Patients Infected With SARS-CoV-2.
Clin Pharmacol Ther. 2020 Aug;108(2):188. doi: 10.1002/cpt.1877. Epub 2020 May 21. PMID: 32350860. https://pubmed.ncbi.nlm.nih.gov/32350860/
- Gautret, P., Lagier, J. C., Parola, P., Hoang, V. T., Meddeb, L., Mailhe, M., Doudier, B., Courjon, J., Giordanengo, V., Vieira, V. E., Tissot Dupont, H., Honoré, S., Colson, P., Chabrière, E., La Scola, B., Rolain, J. M., Brouqui, P., & Raoult, D. (2020).
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
International journal of antimicrobial agents, 56(1), 105949. https://doi.org/10.1016/j.ijantimicag.2020.105949
- Didier Raoult, Matthieu Million, Philippe Gautret, Jean-Christophe Lagier, Philippe Colson, Philippe Parola, and Jean-Marc Rolain.
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial : Response to David Spencer (Elsevier).
Published online 08/07/2020: https://doi.org/10.35088/bjjr-cy47
- Gautret, P., Lagier, J. C., Parola, P., Hoang, V. T., Meddeb, L., Sevestre, J., Mailhe, M., Doudier, B., Aubry, C., Amrane, S., Seng, P., Hocquart, M., Eldin, C., Finance, J., Vieira, V. E., Tissot-Dupont, H. T., Honoré, S., Stein, A., Million, M., Colson, P., … Raoult, D. (2020).
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
Travel medicine and infectious disease, 34, 101663. https://doi.org/10.1016/j.tmaid.2020.101663 https://pubmed.ncbi.nlm.nih.gov/32289548/
- Million, M., Lagier, J. C., Gautret, P., Colson, P., Fournier, P. E., Amrane, S., Hocquart, M., Mailhe, M., Esteves-Vieira, V., Doudier, B., Aubry, C., Correard, F., Giraud-Gatineau, A., Roussel, Y., Berenger, C., Cassir, N., Seng, P., Zandotti, C., Dhiver, C., Ravaux, I., … Raoult, D. (2020).
Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France.
Travel medicine and infectious disease, 35, 101738. https://doi.org/10.1016/j.tmaid.2020.101738 https://pubmed.ncbi.nlm.nih.gov/32387409/
- La Scola, B., Le Bideau, M., Andreani, J., Hoang, V. T., Grimaldier, C., Colson, P., Gautret, P., & Raoult, D. (2020)
Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 39(6), 1059–1061. https://doi.org/10.1007/s10096-020-03913-9https://pubmed.ncbi.nlm.nih.gov/32342252/
- Baron SA, Devaux C, Colson P, Raoult D, Rolain JM.
Teicoplanin: an alternative drug for the treatment of COVID-19?
Int J Antimicrob Agents. 2020;55(4):105944. doi:10.1016/j.ijantimicag.2020.105944 https://pubmed.ncbi.nlm.nih.gov/32179150/
- Tran Duc Anh Ly, Didier Zanini, Vincent Laforge, Sylvie Arlotto, Stephanie Gentile, Helene Mendizabal, Michaël Finaud, David Morel, Olivier Quenette, Priscilla Malfuson-Clot-Faybesse, Alain Midejean, Phuc Le-Dinh, Gérard Daher, Berengere Labarriere, Anne-Marie Morel-Roux, Alain Coquet, Patrick Augier, Philippe Parola, Eric Chabriere, Didier Raoult, Philippe Gautret
Pattern of SARS-CoV-2 infection among dependant elderly residents living in long-term care facilities in Marseille, France, March–June 2020
International Journal of Antimicrobial Agents, Available online 13 November 2020, 106219 https://www.sciencedirect.com/science/article/pii/S0924857920304301
VIROLOGY – ISOLATION – IN VITRO TESTING
- Jaafar R, Aherfi S, Wurtz N, et al.
Corrigendum to: Correlation Between 3790 Quantitative Polymerase Chain Reaction-Positives Samples and Positive Cell Cultures, Including 1941 Severe Acute Respiratory Syndrome Coronavirus 2 Isolates.
Clin Infect Dis. 2021;73(9):1745. doi:10.1093/cid/ciab531
- Colson P, Fantini J, Yahi N, et al.
Limited spread of a rare spike E484K-harboring SARS-CoV-2 in Marseille, France
[published online ahead of print, 2022 Jan 27]. Arch Virol. 2022;1-7. doi:10.1007/s00705-021-05331-4
- Gendrot M, Jardot P, Delandre O, Boxberger M, Andreani J, Duflot I, Le Bideau M, Mosnier J, Fonta I, Hutter S, La Scola B, Pradines B.
In vitro evaluation of the antiviral activity of methylene blue alone or in combination against SARS-CoV-2.
J Clin Med 2021, 10, 3007.
DOI : https://doi.org/10.3390/jcm10143007
- Julie Dergham, Jeremy Delerce, Marielle Bedotto, Bernard La Scola, Valérie Moal
Isolation of viable SARS-CoV-2 in feces suggesting possible fecal transmission of COVID-19
J. Clin. Med. 2021, 10, 2696. https://doi.org/10.3390/jcm10122696
Abstract: https://www.mdpi.com/2077-0383/10/12/2696
PDF Version: https://www.mdpi.com/2077-0383/10/12/2696/pdf
- Andreani, J., Le Bideau, M., Duflot, I., Jardot, P., Rolland, C., Boxberger, M., Wurtz, N., Rolain, J. M., Colson, P., La Scola, B., & Raoult, D. (2020).
In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect.
Microbial pathogenesis, 145, 104228. https://doi.org/10.1016/j.micpath.2020.104228https://pubmed.ncbi.nlm.nih.gov/32344177/
- Gendrot M, Andreani J, Boxberger M, Jardot P, Fonta I, Le Bideau M, Duflot I, Mosnier J, Rolland C, Bogreau H, Hutter S, La Scola B, Pradines B.
Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation.
Travel Med Infect Dis. 2020 Sep 8;37:101873. doi: 10.1016/j.tmaid.2020.101873. Epub ahead of print. PMID: 32916297; PMCID: PMC7477610. https://pubmed.ncbi.nlm.nih.gov/32916297/
- Touret F, Gilles M, Barral K, Nougairède A, van Helden J, Decroly E, de Lamballerie X, Coutard B.
In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication.
Sci Rep. 2020 Aug 4;10(1):13093. doi: 10.1038/s41598-020-70143-6. PMID: 32753646; PMCID: PMC7403393. https://pubmed.ncbi.nlm.nih.gov/32753646/
- Maisonnasse P, Guedj J, Contreras V, Behillil S, Solas C, Marlin R, Naninck T, Pizzorno A, Lemaitre J, Gonçalves A, Kahlaoui N, Terrier O, Fang RHT, Enouf V, Dereuddre-Bosquet N, Brisebarre A, Touret F, Chapon C, Hoen B, Lina B, Calatrava MR, van der Werf S, de Lamballerie X, Le Grand R.
Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates.
Nature. 2020 Sep;585(7826):584-587. doi: 10.1038/s41586-020-2558-4. Epub 2020 Jul 22. PMID: 32698191. https://pubmed.ncbi.nlm.nih.gov/32698191/
- Pastorino B, Touret F, Gilles M, de Lamballerie X, Charrel RN.
Heat Inactivation of Different Types of SARS-CoV-2 Samples: What Protocols for Biosafety, Molecular Detection and Serological Diagnostics?
2020 Jul 7;12(7):735. doi: 10.3390/v12070735. PMID: 32646015; PMCID: PMC7412566. https://pubmed.ncbi.nlm.nih.gov/32646015/
- Pastorino B, Touret F, Gilles M, Luciani L, de Lamballerie X, Charrel RN.
Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples.
2020 Jun 8;12(6):624. doi: 10.3390/v12060624. PMID: 32521706; PMCID: PMC7354533. https://pubmed.ncbi.nlm.nih.gov/32521706/
- Gendrot M, Andreani J, Jardot P, Hutter S, Delandre O, Boxberger M, Mosnier J, Le Bideau M, Duflot I, Fonta I, Rolland C, Bogreau H, La Scola B, Pradines B.
In vitro antiviral activity of doxycycline against SARS-CoV-2.
Molecules, 2020, 25 :5064. Doi: 10.3390/molecules25215064 https://pubmed.ncbi.nlm.nih.gov/33142770/
- Gendrot M, Andreani J, Duflot I, Boxberger M, Le Bideau M, Mosnier J, Jardot P, Fonta I, Rolland C, Bogreau H, Hutter S, La Scola B, Pradines B.
Methylene blue inhibits the replication of SARS-CoV-2 in vitro.
Int J Antimicrob Agents, 2020, 106202. Doi: 10.1016/j.ijantimicag.2020.106202 https://pubmed.ncbi.nlm.nih.gov/33075512/
- Gendrot M, Duflot I, Boxberger M, Delandre O, Jardot P, Le Bideau M, Andreani J, Fonta I, Mosnier J, Rolland C, Hutter S, La Scola B, Pradines B.
Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate.
Int J Infect Dis, 2020, 99 :437-440. Doi: 10.1016/j.ijid.2020.08.032 https://pubmed.ncbi.nlm.nih.gov/32805422/
GENOMICS
- Manry J, Bastard P, Gervais A, et al.
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
Proc Natl Acad Sci U S A. 2022;119(21):e2200413119. doi:10.1073/pnas.2200413119 - Fenollar F, Thomas L, Raoult D, Gautret P.
Screening for SARS-CoV-2 antibodies to save vaccine doses.
Vaccine. 2022;40(22):2984-2985. doi:10.1016/j.vaccine.2022.04.028
- Colson P, Delerce J, Beye M, et al.
First cases of infection with the 21L/BA.2 Omicron variant in Marseille, France.
J Med Virol. 2022;94(7):3421-3430. doi:10.1002/jmv.27695
- Colson P, Fournier PE, Delerce J, et al.
Culture and identification of a « Deltamicron » SARS-CoV-2 in a three cases cluster in southern France [published online ahead of print, 2022 Apr 25]. J Med Virol. 2022;10.1002/jmv.27789. doi:10.1002/jmv.27789
- Colson P, Delerce J, Burel E, et al.
Emergence in southern France of a new SARS-CoV-2 variant harbouring both N501Y and E484K substitutions in the spike protein. Arch Virol. 2022;167(4):1185-1190. doi:10.1007/s00705-022-05385-y
- Laidoudi Y, Sereme Y, Medkour H, et al.
SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assay.
One Health. 2021;13:100293. Published 2021 Jul 18. doi:10.1016/j.onehlt.2021.100293
- Osman IO, Levasseur A, Brechard L, et al.
Whole Genome Sequencing of SARS-CoV-2 Strains in COVID-19 Patients From Djibouti Shows Novel Mutations and Clades Replacing Over Time.
Front Med (Lausanne). 2021;8:737602. Published 2021 Sep 1. doi:10.3389/fmed.2021.737602
- Devaux CA, Pinault L, Delerce J, Raoult D, Levasseur A, Frutos R.
Spread of Mink SARS-CoV-2 Variants in Humans: A Model of Sarbecovirus Interspecies Evolution.
Front Microbiol. 2021;12:675528. Published 2021 Sep 20. doi:10.3389/fmicb.2021.675528
- Colson P, Delerce J, Burel E, et al.
Occurrence of a substitution or deletion of SARS-CoV-2 spike amino acid 677 in various lineages in Marseille, France.
Virus Genes. 2022;58(1):53-58. doi:10.1007/s11262-021-01877-2
- Fantini J, Yahi N, Colson P, Chahinian H, La Scola B, Raoult D.
The puzzling mutational landscape of the SARS-2-variant Omicron
[published online ahead of print, 2022 Jan 8]. J Med Virol. 2022;10.1002/jmv.27577. doi:10.1002/jmv.27577
- Houhamdi L, Gautret P, Hoang VT, Fournier PE, Colson P, Raoult D.
Characteristics of the first 1119 SARS-CoV-2 Omicron variant cases, in Marseille, France, November-December 2021
[published online ahead of print, 2022 Jan 20]. J Med Virol. 2022;10.1002/jmv.27613. doi:10.1002/jmv.27613
- Van Thuan Hoang, Philippe Colson, Anthony Levasseur, Jérémy Delerce, Jean-Christophe Lagier, Philippe Parola, Matthieu Million, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret
Clinical outcomes in patients infected with different SARS-CoV-2 variants at one hospital during three phases of the COVID-19 epidemic in Marseille, France
https://doi.org/10.1016/j.meegid.2021.105092
- Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E.
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
Antiviral Res. 2020 Apr;176:104742. doi: 10.1016/j.antiviral.2020.104742. Epub 2020 Feb 10. PMID: 32057769; PMCID: PMC7114094.
MICROSCOPY
- Francis R, Le Bideau M, Jardot P, Grimaldier C, Raoult D, Bou Khalil JY, La Scola B.
High-speed large-scale automated isolation of SARS-CoV-2 from clinical samples using miniaturized co-culture coupled to high-content screening.
Clin Microbiol Infect. 2020 Sep 23:S1198-743X(20)30570-X. doi: 10.1016/j.cmi.2020.09.018. Epub ahead of print. PMID: 32979576; PMCID: PMC7510445.
- Colson P, Lagier JC, Baudoin JP, Bou Khalil J, La Scola B, Raoult D.
Ultrarapid diagnosis, microscope imaging, genome sequencing, and culture isolation of SARS-CoV-2.
Eur J Clin Microbiol Infect Dis. 2020;39(8):1601-1603. doi:10.1007/s10096-020-03869-w https://pubmed.ncbi.nlm.nih.gov/32270412/
- Djamal Brahim Belhaouari, Anthony Fontanini, Jean-Pierre Baudoin, Gabriel Haddad, Marion Le Bideau, Jacques Yaacoub Bou Khalil, Didier Raoult and Bernard La Scola.
The strengths of scanning electron microscopy in deciphering SARS-CoV-2 infectious cycle.
Frontiers in Microbiology VOLUME=11 YEAR=2020 PAGES=2014 3389/fmicb.2020.02014 https://www.frontiersin.org/article/10.3389/fmicb.2020.02014
IMMUNOLOGY
- Bertin, D., Brodovitch, A., Beziane, A., Hug, S., Bouamri, A., Mege, J. L., & Bardin, N. (2020).
Anti-cardiolipin IgG autoantibodies are an independent risk factor of COVID-19 severity.
Arthritis & rheumatology (Hoboken, N.J.), 10.1002/art.41409. Advance online publication. https://doi.org/10.1002/art.41409https://pubmed.ncbi.nlm.nih.gov/32564467/
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- Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Çölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela ŞN, Gallego CR, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-19; Biobank; COVID Human Genetic Effort; NIAID-USUHS; TAGC COVID Immunity Group, Snow AL, Dalgard CL, Milner J, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli M, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton R, Zhang SY, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science. 2020 Sep 24:eabd4570. doi: 10.1126/science.abd4570. Epub ahead of print. PMID: 32972995.
- Melenotte C, Silvin A, Goubet AG, Lahmar I, Dubuisson A, Zumla A, Raoult D, Merad M, Gachot B, Hénon C, Solary E, Fontenay M, André F, Maeurer M, Ippolito G, Piacentini M, Wang FS, Ginhoux F, Marabelle A, Kroemer G, Derosa L, Zitvogel L.
Immune responses during COVID-19 infection.
Oncoimmunology. 2020 Aug 25;9(1):1807836. doi: 10.1080/2162402X.2020.1807836. PMID: 32939324; PMCID: PMC7480812.
- Vitte J, Michel M, Mezouar S, Diallo AB, Boumaza A, Mege JL, Desnues B.
Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines.
Front Immunol. 2020 Aug 28;11:2159. doi: 10.3389/fimmu.2020.02159. PMID: 32983179; PMCID: PMC7484884.
- Vitte J, Diallo AB, Boumaza A, Lopez A, Michel M, Allardet-Servent J, Mezouar S, Sereme Y, Busnel JM, Miloud T, Malergue F, Morange PE, Halfon P, Olive D, Leone M, Mege JL.
A granulocytic signature identifies COVID-19 and its severity.
J Infect Dis. 2020 Sep 17:jiaa591. doi: 10.1093/infdis/jiaa591. Epub ahead of print. PMID: 32941618; PMCID: PMC7543529.
- Pierre-Edouard FOURNIER,
Contribution of VitaPCR SARS-CoV-2 to the emergency diagnosis of COVID-19
In press Journal of Clinical Virology.
DIAGNOSIS
- Devaux CA, Melenotte C, Piercecchi-Marti MD, Delteil C, Raoult D.
Cyclosporin A: A Repurposable Drug in the Treatment of COVID-19?
Front Med (Lausanne). 2021;8:663708. Published 2021 Sep 6. doi:10.3389/fmed.2021.663708
- Aherfi S, Pradines B, Devaux C, et al.
Drug repurposing against SARS-CoV-1, SARS-CoV-2 and MERS-CoV.
Future Microbiol. 2021;16:1341-1370. doi:10.2217/fmb-2021-0019
- Melo Costa M, Benoit N, Tissot-Dupont H, Million M, Pradines B, Granjeaud S, Almeras L. Mouth
Washing impaired SARS-CoV-2 detection in saliva
Diagnostics 2021, 11, 1509
DOI: https://doi.org/10.3390/diagnostics11081509
- Melo Costa M, Benoit N, Saby F, Pradines B, Granjeaud S, Almeras L.
Optimization and standardization of human saliva collection for MALDI-TOF MS.
Diagnostics 2021, 11, 1304.
doi: https://doi.org/10.3390/diagnostics11081304
- Melo Costa M, Benoit N, Dormoi J, Amalvict R, Gomez N, Tissot-Dupont H, Million M, Pradines B, Grandjeud S, Almeras L.
Salivette, a relevant saliva sampling device for SARS-CoV-2 detection
J Oral Microbiol 2021, 13, 1920226.
DOI: https://doi.org/10.1080/20002297.2021.1920226
- Philippe COLSON, Christian A DEVAUX and Didier RAOULT
A possible role of COVID-19 therapy in the selective sweep and emergence of new SARS-CoV-2 variants
Abstract: https://www.mdpi.com/2077-0383/10/15/3276
PDF Version: https://www.mdpi.com/2077-0383/10/15/3276/pdf
Special Issue: https://www.mdpi.com/journal/jcm/special_issues/Public_Health_COVID
- Amrane, S., Tissot-Dupont, H., Doudier, B., Eldin, C., Hocquart, M., Mailhe, M., Dudouet, P., Ormières, E., Ailhaud, L., Parola, P., Lagier, J. C., Brouqui, P., Zandotti, C., Ninove, L., Luciani, L., Boschi, C., La Scola, B., Raoult, D., Million, M., Colson, P., … Gautret, P. (2020).
Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France – January 31st to March 1st, 2020: A respiratory virus snapshot.
Travel medicine and infectious disease, 101632. Advance online publication. https://doi.org/10.1016/j.tmaid.2020.101632
- Boudjema S, Finance J, Coulibaly F, Meddeb L, Tissot-Dupont H, Michel M, Lagier JC, Million M, Radulesco T, Michel J, Brouqui P, Raoult D, Fenollar F, Parola P.
Olfactory and gustative disorders for the diagnosis of COVID-19.
Travel Med Infect Dis. 2020 Sep 6;37:101875. doi: 10.1016/j.tmaid.2020.101875. Epub ahead of print. PMID: 32898703; PMCID: PMC7474847.
- Jaafar R, Aherfi S, Wurtz N, Grimaldier C, Hoang VT, Colson P, Raoult D, La Scola B.
Correlation between 3790 qPCR positives samples and positive cell cultures including 1941 SARS-CoV-2 isolates.
Clin Infect Dis. 2020 Sep 28:ciaa1491. doi: 10.1093/cid/ciaa1491. Epub ahead of print. PMID: 32986798; PMCID: PMC7543373.
- Pezzi L, Charrel RN, Ninove L, Nougairede A, Molle G, Coutard B, Durand G, Leparc-Goffart I, de Lamballerie X, Thirion L.
Development and Evaluation of a duo SARS-CoV-2 RT-qPCR Assay Combining Two Assays Approved by the World Health Organization Targeting the Envelope and the RNA-Dependant RNA Polymerase (RdRp) Coding Regions.
Viruses. 2020 Jun 25;12(6):686. doi: 10.3390/v12060686. PMID: 32630601; PMCID: PMC7354606.
- Pastorino B, Touret F, Gilles M, de Lamballerie X, Charrel RN.
Prolonged Infectivity of SARS-CoV-2 in Fomites.
Emerg Infect Dis. 2020 Sep;26(9):2256–7. doi: 10.3201/eid2609.201788. Epub 2020 Jun 24. PMID: 32579874; PMCID: PMC7454106.
- Nathalie Wurtz, Gwilherm Penant, Priscilla Jardot, Nathalie Duclos and Bernard La Scola
Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity and differences in growth profile
European Journal of Clinical Microbiology & Infectious Diseases
EPIDEMIOLOGY
- Davoust B, Guérin P, Orain N, Fligny C, Flirden F, Fenollar F, Mediannikov O, Edouard S.
Evidence of antibodies against SARS-CoV-2 in wild mustelids from Brittany (France). Transbound Emerg Dis. 2022 Jul 16.
doi: 10.1111/tbed.14663. https://pubmed.ncbi.nlm.nih.gov/35841263/
- Arlotto S, Legueult K, Blin A, et al.
Who Were Hospitalized Deceased Patients from COVID-19 During the First Year of Pandemic? Retrospective Analysis of 1104 Deceased Patients in South of France [published online ahead of print, 2022 Apr 29]. J Epidemiol Glob Health. 2022;1-10. doi:10.1007/s44197-022-00039-3
- Hoang VT, Assoumani L, Delerce J, et al.
Introduction of the SARS-CoV-2 Beta variant from Comoros into the Marseille geographical area. Travel Med Infect Dis. 2022;46:102277. doi:10.1016/j.tmaid.2022.102277
- Giraud-Gatineau A, Kaba L, Boschi C, et al.
Control of common viral epidemics but not of SARS-CoV-2 through the application of hygiene and distancing measures. J Clin Virol. 2022;150-151:105163. doi:10.1016/j.jcv.2022.105163
- Nguyen NN, Houhamdi L, Hoang VT, et al.
High rate of reinfection with the SARS-CoV-2 Omicron variant [published online ahead of print, 2022 Apr 23]. J Infect. 2022;S0163-4453(22)00216-X. doi:10.1016/j.jinf.2022.04.034
- Colson P, Parola P, Raoult D.
The emergence, dynamics and significance of SARS-CoV-2 variants
[published online ahead of print, 2022 Feb 1]. New Microbes New Infect. 2022;100962. doi:10.1016/j.nmni.2022.100962
- Gautret P, Hoang VT, Jimeno MT, et al.
The severity of the first 207 infections with the SARS-CoV-2 Omicron BA.2 variant, in Marseille, France, December 2021-February 2022 [published online ahead of print, 2022 Apr 1]. J Med Virol. 2022;10.1002/jmv.27760. doi:10.1002/jmv.27760
- Medkour H, Catheland S, Boucraut-Baralon C, Laidoudi Y, Sereme Y, Pingret JL, Million M, Houhamdi L, Levasseur A, Cabassu J, Davoust B.
First evidence of human-to-dog transmission of SARS-CoV-2 B.1.160 variant in France.
Transbound Emerg Dis. 2021.
Link to the article : https://www.sciencedirect.com/science/article/pii/S2352771421000835
- Lancei KABA, Audrey GIRAUD-GATINEAU, Marie-Thérèse JIMENO, Jean-Marc ROLAIN, Philippe COLSON, Didier RAOULT, Hervé CHAUDET
Consequences of the COVID-19 Outbreak Lockdown on Non-Viral Infectious Agents as Reported by a Laboratory-Based Surveillance System at the IHU Méditerranée Infection, Marseille, France
Abstract: https://www.mdpi.com/2077-0383/10/15/3210
PDF Version: https://www.mdpi.com/2077-0383/10/15/3210/pdf
Special Issue: https://www.mdpi.com/journal/jcm/special_issues/Public_Health_COVID
- Younes Laidoudi, Youssouf Sereme, Hacène Medkour, Stéphanie Watier-Grillot, Pierre Scandola, Jacques Ginesta, Virginie Andréo, Claire Labarde, Loïc Comtet, Philippe Pourquier, Didier Raoult, Jean-Lou Marié, Bernard Davoust
SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assay
One Health 13 (2021) 100293
Link to the PDF version
- Audrey GIRAUD-GATINEAU; Philippe GAUTRET; Philippe COLSON; Hervé CHAUDET; Didier RAOULT
Evaluation of strategies to fight COVID-19: The French paradigm
J. Clin. Med. 2021, 10, 2942. https://doi.org/10.3390/jcm10132942
Abstract: https://www.mdpi.com/2077-0383/10/13/2942
PDF Version: https://www.mdpi.com/2077-0383/10/13/2942/pdf
- Thi Loi Dao, Van Thuan Hoang, Philippe Colson, Jean Christophe Lagier, Didier Raoult , Anthony Levasseur , Philippe Gautret, Matthieu Million
SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence
J. Clin. Med. 2021, 10, 2635. https://doi.org/10.3390/jcm10122635
Abstract: https://www.mdpi.com/2077-0383/10/12/2635
PDF Version: https://www.mdpi.com/2077-0383/10/12/2635/pdf
- Pierre-Edouard FOURNIER, Sophie EDOUARD, Nathalie WURTZ , Justine RACLOT, Marion BECHET, Christine ZANDOTTI, Véronique FILOSA, Didier RAOULT, Florence FENOLLAR
Contagion management at the Mediterranée Infection University Hospital Institute
J. Clin. Med. 2021, 10, 2627. https://doi.org/10.3390/jcm10122627
Abstract: https://www.mdpi.com/2077-0383/10/12/2627
PDF Version: https://www.mdpi.com/2077-0383/10/12/2627/pdf
- Roussel, Y., Giraud-Gatineau, A., Jimeno, M. T., Rolain, J. M., Zandotti, C., Colson, P., & Raoult, D. (2020).
SARS-CoV-2: fear versus data.
International journal of antimicrobial agents, 55(5), 105947. https://doi.org/10.1016/j.ijantimicag.2020.105947 https://pubmed.ncbi.nlm.nih.gov/32201354/
- Giraud-Gatineau, A., Colson, P., Jimeno, M. T., Zandotti, C., Ninove, L., Boschi, C., Lagier, J. C., La Scola, B., Chaudet, H., & Raoult, D. (2020).
Comparison of mortality associated with respiratory viral infections between December 2019 and March 2020 with that of the previous year in Southeastern France.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 96, 154–156. https://doi.org/10.1016/j.ijid.2020.05.001. https://pubmed.ncbi.nlm.nih.gov/32389848/
- Colson, P., Tissot-Dupont, H., Morand, A., Boschi, C., Ninove, L., Esteves-Vieira, V., Gautret, P., Brouqui, P., Parola, P., Lagier, J. C., Zandotti, C., Million, M., La Scola, B., & Raoult, D. (2020).
Children account for a small proportion of diagnoses of SARS-CoV-2 infection and do not exhibit greater viral loads than adults.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1–5. Advance online publication. https://doi.org/10.1007/s10096-020-03900-0https://pubmed.ncbi.nlm.nih.gov/32845413/
- Colson, P., La Scola, B., Esteves-Vieira, V., Ninove, L., Zandotti, C., Jimeno, M. T., Gazin, C., Bedotto, M., Filosa, V., Giraud-Gatineau, A., Chaudet, H., Brouqui, P., Lagier, J. C., & Raoult, D. (2020).
Letter to the editor: Plenty of coronaviruses but no SARS-CoV-2.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 25(8), 2000171. https://doi.org/10.2807/1560-7917.ES.2020.25.8.2000171. https://pubmed.ncbi.nlm.nih.gov/32127122/
- Colson P, Esteves-Vieira V, Giraud-Gatineau A, Zandotti C, Filosa V, Chaudet H, Lagier JC, Raoult D.
Temporal and age distributions of SARS-CoV-2 and other coronaviruses, Southeastern France.
Int J Infect Dis. 2020 Sep 22:S1201-9712(20)32133-0. doi: 10.1016/j.ijid.2020.09.1417. Epub ahead of print. PMID: 32976991; PMCID: PMC7511210.
- Gautret P, Colson P, Lagier JC, Camoin-Jau L, Giraud-Gatineau A, Boudjema S, Finance J, Chaudet H, Raoult D.
Different pattern of the second outbreak of COVID-19 in Marseille, France.
Int J Infect Dis. 2020 Oct 7:S1201-9712(20)32208-6. doi: 10.1016/j.ijid.2020.10.005. Epub ahead of print. PMID: 33038556.
- Gallian P, Pastorino B, Morel P, Chiaroni J, Ninove L, de Lamballerie X.
Lower prevalence of antibodies neutralizing SARS-CoV-2 in group O French blood donors.
Antiviral Res. 2020 Sep;181:104880. doi: 10.1016/j.antiviral.2020.104880. Epub 2020 Jul 15. PMID: 32679056; PMCID: PMC7362788.
- Laloui R, Bakour S, Raoult D, Verger P, Sokhna C, Devaux C, Pradines B, Rolain JM.
What could explain the late emergence of COVID-19 in Africa?
New Microbes New Infect, 2020, 38 :100760. Doi: 10.1016/j.nmni.2020.100760
HUMAN AND SOCIAL SCIENCES
- Ward JK, Alleaume C, Peretti-Watel P; COCONEL Group.
The French public’s attitudes to a future COVID-19 vaccine: The politicization of a public health issue.
Social Science and Medicine, 265:113414. doi: 10.1016/j.socscimed.2020.113414.
- COCONEL Study Group.
Attitudes about COVID-19 Lockdown among General Population, France, March 2020.
Emerging Infectious Diseases (à paraître).
- Peretti-Watel P, Alleaume C, Léger D, Beck F, Verger P.
Anxiety, depression and sleep problems: a second wave of COVID-19.
General Psychiatry, 33 (5) e100299; DOI: 10.1136/gpsych-2020-100299.
- Léger D., Beck F., Fressard L., Verger P., Peretti-Watel P., and the COCONEL Group.
Poor Sleep Associated with Overuse of Media during the COVID-19 Lockdown.
Sleep doi: 10.1093/sleep/zsaa125.
- Patrick Peretti-Watel and the COCONEL Study Group.
A future vaccination campaign against COVID-19 at risk of vaccine hesitancy and politicization.
Lancet Infectious Diseases, 2020. doi: 10.1016/S1473-3099(20)30426-6.
- Beck F., Léger D., Fressard L., Peretti-Watel P., Verger P. & the COCONEL group.
Covid-19 health crisis and lockdown associated with high level of sleep complaints and hypnotic uptake at the population level.
Journal of Sleep Research. doi: 10.1111/jsr.13119.
- Lambert A, Cayouette-Remblière J, Guéraut É, Le Roux G, Bonvalet C, Girard V, Langlois L.
Le travail et ses aménagements : ce que la pandémie de covid-19a changé pour les Français,
Population & Sociétés, Numéro 579,
- Lambert A, Cayouette-Remblière J, Guéraut É, Le Roux G, Bonvalet C, Girard V, Langlois L.
Comment voisine-t-on dans la France confinée ?
Population & Sociétés, Numéro 578, juillet 2020.
COMMENTARIES – PERSPECTIVES
- Sokhna C, Brah S, Djimde A, Mouffok N, Zahraoui M, Boukhary AOMS, Bitam I, Cisse B, Thera MA, Lekana-Douki JB, Adehossi E, Seydi M, Akiana J, Heikel J, Lagier JC, Mboup S, Mouyembe-Tamfum JJ, Parola P.
COVID-19 in africa: what else?
New Microbes New Infect. 2022 May 9:100982. doi: 10.1016/j.nmni.2022.100982.
PMID: 35573042; PMCID: PMC9081042.
Link: https://doi.org/10.1016/j.nmni.2022.100982
- Philippe Brouqui, Michel Drancourt, Didier Raoult and on behalf of the IHU Task Force
COVID-19 Management at IHU Méditerranée Infection: A One-Year Experience
J. Clin. Med. 2021, 10, 2881. https://doi.org/10.3390/jcm10132881
Abstract: https://www.mdpi.com/2077-0383/10/13/2881
PDF Version: https://www.mdpi.com/2077-0383/10/13/2881/pdf
- Lagier, J. C., Colson, P., Tissot Dupont, H., Salomon, J., Doudier, B., Aubry, C., Gouriet, F., Baron, S., Dudouet, P., Flores, R., Ailhaud, L., Gautret, P., Parola, P., La Scola, B., Raoult, D., & Brouqui, P. (2020).
Testing the repatriated for SARS-Cov2: Should laboratory-based quarantine replace traditional quarantine?
Travel medicine and infectious disease, 34, 101624. https://doi.org/10.1016/j.tmaid.2020.101624https://pubmed.ncbi.nlm.nih.gov/32179125/
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Christian A. Devaux, Laurence Camoin-Jau, Jean-Louis Mege, Didier Raoult (2020)
Can hydroxychloroquine be protective against COVID-19-associated thrombotic events ?
Journal of Microbiology, Immunology and Infection
https://www.sciencedirect.com/science/article/pii/S1684118221000074?via%3Dihub -
ChristianA.Devaux, LucilePinault, IkramOmarOsman, DidierRaoult (2021)
Can ACE2 Receptor Polymorphism Predict Species Susceptibility to SARS-CoV-2 ?
Frontiers in Public Health
https://www.frontiersin.org/articles/10.3389/fpubh.2020.608765/full
- Gautret P, Raoult D.
Nullane salus extra ecclesiam.
New Microbes New Infect. 2020;37:100714. doi:10.1016/j.nmni.2020.100714 https://pubmed.ncbi.nlm.nih.gov/32834899/
- Million M, Roussel Y, Raoult D.
Chloroquine and COVID-19: A western medical and scientific drift?
Eur J Intern Med. 2020;78:4-5. doi:10.1016/j.ejim.2020.06.020 https://pubmed.ncbi.nlm.nih.gov/32600860/
- Javelle E, Raoult D.
COVID-19 pandemic more than a century after the Spanish flu [published online ahead of print, 2020 Aug 11].
Lancet Infect Dis. 2020;S1473-3099(20)30650-2. doi:10.1016/S1473-3099(20)30650-2 https://pubmed.ncbi.nlm.nih.gov/32795410/
- Raoult D, Zumla A, Locatelli F, Ippolito G, Kroemer G.
Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses.
Cell Stress. 2020;4(4):66-75. Published 2020 Mar 2. doi:10.15698/cst2020.04.216 https://pubmed.ncbi.nlm.nih.gov/32292881/
- Devaux CA, Rolain JM, Raoult D.
ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome.
J Microbiol Immunol Infect. 2020;53(3):425-435. doi:10.1016/j.jmii.2020.04.015 https://pubmed.ncbi.nlm.nih.gov/32414646/
- Roussel Y, Raoult D.
Hydroxychloroquine recommendations toward the world: first evaluations.
New Microbes New Infect. 2020 Sep 22:100759. doi: 10.1016/j.nmni.2020.100759. Epub ahead of print. PMID: 32983541; PMCID: PMC7508006.
- Million, M., Chaudet, H., & Raoult, D. (2020).
Hydroxychloroquine Failure: The End does not justify the Means.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ciaa1117. Advance online publication. https://doi.org/10.1093/cid/ciaa1117https://pubmed.ncbi.nlm.nih.gov/32761148/
- Lalaoui R, Bakour S, Raoult D, Verger P, Sokhna C, Devaux C, Pradines B, Rolain JM.
What could explain the late emergence of COVID-19 in Africa?
New Microbes New Infect. 2020 Nov;38:100760. doi: 10.1016/j.nmni.2020.100760. Epub 2020 Sep 22. PMID: 32983542; PMCID: PMC7508045.
- Raoult D.
Lancet gate: a matter of fact or a matter of concern.
New Microbes New Infect. 2020 Nov;38:100758. doi: 10.1016/j.nmni.2020.100758. Epub 2020 Sep 22. PMID: 32983540; PMCID: PMC7508049.
- Million M, Roussel Y, Lagier JC, Raoult D.
Re: ‘effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients’ by Fiolet et al.
Clin Microbiol Infect. 2020 Sep 24:S1198-743X(20)30578-4. doi: 10.1016/j.cmi.2020.09.026. Epub ahead of print. PMID: 32980527.
- Touret F, de Lamballerie X.
Of chloroquine and COVID-19.
Antiviral Res. 2020 May;177:104762. doi: 10.1016/j.antiviral.2020.104762. Epub 2020 Mar 5. PMID: 32147496; PMCID: PMC7132364.
- Frutos R, Serra-Cobo J, Chen T, Devaux CA.
COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans.
Infect Genet Evol. 2020 Oct;84:104493. doi: 10.1016/j.meegid.2020.104493. Epub 2020 Aug 5. PMID: 32768565; PMCID: PMC7405773.
- Frutos R, Lopez Roig M, Serra-Cobo J, Devaux CA.
COVID-19: The Conjunction of Events Leading to the Coronavirus Pandemic and Lessons to Learn for Future Threats.
Front Med (Lausanne). 2020 May 12;7:223. doi: 10.3389/fmed.2020.00223. PMID: 32574324; PMCID: PMC7235412.
- Devaux CA, Rolain JM, Colson P, Raoult D.
New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
Int J Antimicrob Agents. 2020;55(5):105938. doi:10.1016/j.ijantimicag.2020.105938 https://pubmed.ncbi.nlm.nih.gov/32171740/
- Raoult D.
Rational for meta-analysis and randomized treatment: the COVID-19 example.
Clin Microbiol Infect. 2020 Oct 21:S1198-743X(20)30643-1. doi: 10.1016/j.cmi.2020.10.012. Epub ahead of print. PMID: 33098998.
- Roussel Y, Million M, Chabriere E, Lagier JC, Raoult D.
Be careful with Big Data: Re-analysis of Patient Characteristics and Outcomes of 11,721 Patients with COVID19 Hospitalized Across the United States.
Clin Infect Dis. 2020 Oct 22:ciaa1618. doi: 10.1093/cid/ciaa1618. Epub ahead of print. PMID: 33086376.
- Devaux C.
Are ACE inhibitors and ARBs more beneficial than harmful in the treatment of severe COVID-19 disease?
J. Cardiovascular Med. Cardio. : 7(2): 101-103. DOI: https://dx.doi.org/10.17352/2455-2976.000122
- Gendrot M, Javelle E, Clerc A, Savini H, Pradines B.
Chloroquine as a prophylactic agent against COVID-19?
Int J Antimicrob Agents, 2020, 55 :105980. Doi: 10.1016/j.ijantimicag.2020.105980
NUMÉRO SPÉCIAL IHU
Version 1 du 8 février 2021
Two-millennia fighting against port-imported epidemics, Marseille
Barbieri, R, Colson, P., Raoult, D., Drancourt, M
Version 1 du 8 février 2021
What neo semeiology brings to the care of patient with COVID-19
Philippe Brouqui MD, PhD, Carole Eldin MD, PhD, Sophia Boudjema RN PhD & Didier Raoult MD PhD
Link to the article
BROUQUI Neosemiology Table
BROUQUI Neosemiology Panel
Brouqui Neosemiology Figure
Version 1 du 8 février 2021
Epidemiological surveillance of respiratory viral infections at IHU Méditerranée Infection and its application to SARS-CoV-2
Philippe COLSON, Audrey GIRAUD-GATINEAU, Pierre-Edouard FOURNIER, Laetitia NINOVE, Christine ZANDOTTI, Marie-Thérèse JIMENO, Céline BOSCHI, Léa LUCIANI, Lancei KABA, Philippe PAROLA, Stéphane RANQUE, Jean-Marc ROLAIN, Philippe GAUTRET, Michel DRANCOURT, Jean-Christophe LAGIER, Bernard LA SCOLA, Hervé CHAUDET, Didier RAOULT
Version 1 du 8 février 2021
Point-of-care diagnosis of COVID-19 at IHU Méditerranée Infection, Marseille, France
A. Bouam, M. Boualam, P-Y. Levy, S. Honoré, B. La Scola, P-E. Fournier, D. Raoult, M. Drancourt,
Link to the article
IHU_Bouam_Drancourt_Jan2021vD
Supplementary tables
Figures
SupplFigures
Version 1 du 8 février 2021
In vitro Evaluation of the Antiviral Activity of Repurposable Drugs against SARS-CoV- 2 : Methylene Blue
Mathieu Gendrot, Priscilla Jardot, Océane Delandre, Manon Boxberger, Julien Andreani, Isabelle Duflot, Marion Le Bideau, Joel Mosnier, Isabelle Fonta, Sébastien Hutter, Bernard La Scola and Bruno Pradines
Version 1 du 8 février 2021
Genome sequence analysis enabled deciphering the atypical evolution of COVID-19 epidemics in Marseille, France
Pierre-Edouard FOURNIER, Philippe COLSON, Anthony LEVASSEUR, Philippe GAUTRET, Marielle BEDOTTO, Véronique FILOSA, Jeremy DELERCE, Ludivine BRECHARD, Jean-Christophe LAGIER, Hervé CHAUDET, Florence FENOLLAR, Didier RAOULT
Link to the article
SUPPLEMENTARY MATERIAL 04-01-2020
Cover letter
Figures
Version 1 du 8 février 2021
Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates
Céline Boschi, Marion Le Bideau , Julien Andreani, Sarah Aherfi, Priscilla Jardot, Jeremy Delerce, Mathieu Gendrot, Bruno Pradines, Philippe Colson, Didier Raoult, Anthony Levasseur, Bernard La Scola
Link to the article
CoverLetter
Supplementary table 1
Figures
Article Boschi et al
Version 1 du 8 février 2021
Evolution of the management of COVID-19
Jean-Christophe Lagier, Matthieu Million, Laurence Camoin-Jau, Carole Eldin, Grégory Dubourg, Hervé Tissot-Dupont, Didier Raoult, Philippe Brouqui and Philippe Parola
Version du 5 aout 2021
COVID-19 in Africa : What else ?
Cheikh Sokhna, Souleymane Brah, Abdoulaye Djimde, Nadjet Mouffok, Majida Zahraoui, Ali Ould Mohamed Salem Boukhary, Idir Bitam, Badara Cisse, Mahamadou Ali Thera, Jean-Bernard Lekana-Douki, Eric Adehossi, Moussa Seydi, Jean Akiana, Jaafar Heikel, Jean-Christophe Lagier, Souleymane Mboup, Jean-Jacques Mouyembe-Tamfum, Philippe Parola
Version 1 du 8 février 2021
New Institute to fight threats: the COVID-19 paradigm
Brouqui P., Drancourt M., Raoult D
Link to the article
Table 1
Organigramme
Fig1
CL_IHU_Raoult_Jan2021vD
Version 1 du 8 février 2021
Impact of COVID-19 over Infectious Diseases publications, 2020
Roussel, Y., Ouanezar, A., Grine, G.
Version 1 du 8 février 2021
How is built the “legitimate information”on the Covid crisis
Laurent MUCCHIELLI
CLINICAL OBSERVATIONAL STUDIES AND COHORTS
Version 1 du 15 février 2021
FDG-PET/CT revealing aortic hypermetabolism in patients with chest pain after COVID-19: a retrospective study
Pierre Dudouet, Serge Cammilleri, Alexis Jacquier, Eric Guedj, Didier Raoult, Carole Eldin
Version 1 du 28 janvier 2021
Predictive Factors of Clinical Assays during COVID-19
Matthieu MILLION, Pierre DUDOUET, Eric CHABRIERE, Sébastien CORTAREDONA, Philippe BROUQUI, Didier RAOULT
Link to the article
Supplementary data
Supplementary file
Figure 1
Figure 2
Version 1 du 24 novembre 2020
Re: Covid-19: politicisation, “corruption,” and suppression of science
Matthieu MILLION, Didier RAOULT
Version 1 du 08 Juin 2020
Adjusting series of patients for trial comparisons for COVID-19 treatments
Audrey GIRAUD-GATINEAU, Jean-Christophe LAGIER, Yolande OBADIA, Hervé CHAUDET, Didier RAOULT
Version 1 du 22 avril 2020
Response to Magagnoli, MedRxiv, 2020
Matthieu MILLION, Yanis ROUSSEL, Didier RAOULT
GENOMICS
Version 1 du 13 août 2021
Isolation of nearly 4000 SARS-CoV-2 shows increase of 1 contagiousness associated with alpha then delta variant
Celine Boschi, Sarah Aherfi, Philippe Colson, Didier Raoult and Bernard La Scola
Version 1 du 21 juillet
Limited spread of a rare spike E484K-harboring SARS-CoV-2 in Marseille, France
Philippe COLSON, Jacques FANTINI, Nouara YAHI, Jeremy DELERCE, Anthony LEVASSEUR, Pierre-Edouard FOURNIER, Jean-Christophe LAGIER, Didier RAOULT, Bernard LA SCOLA
Link to the article
DOI : https://doi.org/10.35088/2ngw-sa32
Version 1 du 25 juin
Occurrence of a substitution or deletion of SARS-CoV-2 spike amino acid 677 in various lineages in Marseille, France
Philippe COLSON, Jeremy DELERCE, Emilie BUREL, Mamadou BEYE, Pierre-Edouard FOURNIER, Anthony LEVASSEUR, Jean-Christophe LAGIER, Didier RAOULT
Link to the article
DOI : https://doi.org/10.35088/hcap-1y72
Version 1 du 8 février 2021
Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates
Celine Boschi, Marion Le Bideau, Julien Andreani, Sarah Aherfi, Priscilla Jardot, Jeremy Delerce, Mathieu Gendrot, Bruno Pradines, Philippe Colson, Didier Raoult, Anthony Levasseur, Bernard La Scola
Version 1 du 2 février 2021
Genome sequence analysis enabled deciphering the atypical evolution of COVID-19 epidemics in Marseille, France
Pierre-Edouard FOURNIER, Philippe COLSON, Anthony LEVASSEUR, Philippe GAUTRET, Marielle BEDOTTO, Véronique FILOSA, Jeremy DELERCE, Ludivine BRECHARD, Jean-Christophe LAGIER, Hervé CHAUDET, Florence FENOLLAR, Didier RAOULT
Version 1 du 07 septembre 2020
Dramatic increase in the SARS-CoV-2 mutation rate and low mortality rate during the second epidemic in summer in Marseille
Philippe COLSON, Anthony LEVASSEUR, Jeremy DELERCE, Hervé CHAUDET, Vincent BOSSI, Mariem BEN KHEDHER, Pierre-Edouard FOURNIER, Jean-Christophe LAGIER, Didier RAOULT
IMMUNOLOGY
Version 1 du 08 septembre 2020
High prevalence of Lupus Anticoagulant in Ambulatory COVID-19 patients: interest of Hydroxychloroquine ?
Laurence Camoin-Jau, Philippe Gautret, Philippe Colson, Jean Christophe Lagier, Hervé Tissot-Dupont, Matthieu Million, Audrey Giraud-Gatineau, Sophia Boudjema, Hervé Chaudet, Didier Raoult
DIAGNOSTIC
Version 1 du 13 Août 2021
Real-Time Detection of Covid-19 positive persons using sniffer dog
Nathalie Wurtz, Alexandre Lacoste, Stéphane Besse, Bernard La Scola
Version 1 du 12 février 2021
Pipeline for drug repurposing of FDA-approved drugs against SARS-CoV-1 and SARS-CoV-2
Sarah Aherfi, Bruno Pradines, Christian Devaux, Stéphane Honore, Philippe Colson, Bernard La Scola, Didier Raoult
Version 1 du 3 février 2021
Cyclosporin A: a repurposable drug in the treatment of COVID-19 ?
Christian A. DEVAUX, Cléa MELENOTTE, Marie-Dominique PIERCECCHI-MARTI, Clémence DELTEIL, and Didier RAOULT
Version 1 du 12 octobre 2020
Living SARS-CoV-2 in feces suggesting possible fecal-oral contamination
Julie Dergham, Jeremy Delerce, Marielle Bedotto, Bernard La Scola, Valérie Moal
ÉPIDÉMIOLOGIE
Version 1 du 20 janvier 2022
Evidence of antibodies against SARS-CoV-2 in wild mustelids from Brittany (France)
Davoust B, Guérin P, Orain N, Fligny C, Flirden F, Fenollar F, Mediannikov O, Edouard S.
Version 1 du 30 avril 2021
Control of common viral epidemics but not of SARS-CoV-2 through the application of hygiene and distancing measures
Audrey Giraud-Gatineau, Lancei Kaba, Céline Boschi, Christian Devaux, Jean-Paul Casalta, Philippe Gautret, Hervé Chaudet, Philippe Colson, Didier Raoult
Version 1 du 18 février 2021
Life-years lost by COVID-19 patients in public hospitals of Marseille (APHM- South-Eastern France): a limited death toll
Sylvie Arlotto, Alice Gares, Audrey Giraud-Gatineau, Jean-Christophe Lagier, Marie Thèrese Jimeno, Patrick Peretti-Watel, Matthieu Million,Philippe Parola, Philippe Brouqui, Didier Raoult, Stephanie Gentile
Version 1 du 10 février 2021
The need for early management in patients with COVID-19
Audrey Giraud-Gatineau; Sébastien Cortaredona; Jean-Christophe Lagier; Matthieu Million; Philippe Brouqui; Yolande Obadia; Patrick Peretti-Watel; Didier Raoult; Stéphanie Gentile
Version 1 du 9 février 2021
Epidemiological surveillance of respiratory viral infections at IHU Méditerranée Infection and its application to SARS-CoV-2
Philippe COLSON, Audrey GIRAUD-GATINEAU & Didier RAOU
Version 1 du 10 Juin 2020
Open screening of SARS-CoV-2 infections in the pediatric population in Marseille, Southern France
Aurélie Morand, PhD, MD1,2*, Tatiana Matteudi1, Alexandre Fabre, PhD, MD3,4, Philippe Minodier, MD5, Emmanuelle Bosdure, MD1, Léa Luciani, PharmD2, Jean-Christophe Dubus, PhD, MD1,6, Matthieu Million, PhD, MD2,6, Hervé Tissot-Dupont, MD2,6, Bernard La Scola, PhD, MD2,6, Philippe Colson, PhD, PharmD2,6, Didier Raoult, PhD, MD2,6, Brigitte Chabrol, PhD, MD1
In this cohort study we reported the first 302 pediatric SARS-CoV-2-positive patients in Marseille, mainly diagnosed thanks to open screening platform (80%).
Version 1 du 07 septembre 2020
Dramatic increase in the SARS-CoV-2 mutation rate and low mortality rate during the second epidemic in summer in Marseille
Philippe COLSON, Anthony LEVASSEUR, Jeremy DELERCE, Hervé CHAUDET, Vincent BOSSI, Mariem BEN KHEDHER, Pierre-Edouard FOURNIER, Jean-Christophe LAGIER, Didier RAOULT
COMMENTARIES – PERSPECTIVES
Version 1 du 2 Juin 2022
What is Futility in Therapeutic Studies?
Matthieu Million, Didier Raoult
Microbes Evolution Phylogeny and Infections (MEPHI), Institut de Recherche pour le Développement, Aix-Marseille Université, Marseille, France
Assistance Publique-Hôpitaux de Marseille, Marseille, France
Link to the letter
DOI :
21 juin 2021
Why has France not given itself the means to show the ineffectiveness of Hydroxychloroquine in COVID-19?
Matthieu MILLION, Sébastien CORTAREDONA, Philippe BROUQUI, Didier RAOULT
21 juin 2021
The War Against Chloroquine
Yanis Roussel, Philippe Gautret, Didier Raoult
31 mai 2021
Evaluating vaccination against SARS-CoV-2
Pierre-Édouard Fournier, Didier Raoult
1er mars 2021
Do remdesivir and plasma therapy favor long-term SARS-CoV-2 infection and mutations in immunocompromised patients?
Philippe Gautret, Jean Christophe Lagier, Philippe Colson, Didier Raoult
16 février 2021
Does remdesivir favor long-term SARS-CoV-2 infection and mutations in immunocompromised patients ?
Philippe Gautret, Jean Christophe Lagier, Philippe Colson, Didier Raoult
16 février 2021
Who would accept a randomized trial in the context of covid-19 ?
Hervé Tissot-Dupont, Didier Raoult
12 février 2021
Opinion for the British Medical Journal – The War Against Chloroquine
Philippe Gautret, Didier Raoult
10 février 2021
Remdesivir could promote the occurrence of SARS-CoV-2 variants
Philippe COLSON, Christian A. DEVAUX, Didier RAOULT
Version 1 du 21 août 2020
Quousque tandem abutere, patientia nostra – Article soumis et rejeté par The New England Journal of Medecine
Didier Raoult, M.D, Ph.D., Jean-Christophe Lagier M.D, Ph.D., Philippe Brouqui, M.D., Ph.D., Philippe Parola, M.D, Ph.D.
Version 1 du 30 juin 2020
Does IHU Mediterranean Infection influence Gilead stock price ?
Eric Chabrière
The Lancet Covid-19 Therapy Study: another miss-out
(On Covid-19 and Hydroxychloroquine The Lancet – SCANDAL)
Dragan Pavlovic
Version 2 du 18 Juin 2020
Why randomised Controlled Trials during epidemic
Philippe Brouqui, Didier Raoult
In epidemics there is an urgent need for new knowledge on drug efficacy to help policymakers fight the crisis. Yet the best research methodology to do this is a matter of debate, write Philippe Brouqui and Didier Raoult.