Le site des prépublications de l’IHU sur le COVID-19
Compte-tenu de la vitesse d’évolution de l’épidémie et des besoins de renseignements permanents pour la communauté scientifique, associé à la difficulté des déplacements, la fondation a décidé de mettre online les articles soumis (preprint), comme ont déjà commencé à le faire les sites mais qui dans la situation actuelle ont des délais trop importants pour être compatibles avec les besoins de rapidité que nous avons.
Dès aujourd’hui, toutes les publications que nous soumettrons seront mises en preprint sur notre site et seront remplacées par un lien vers une publication scientifique officielle, dès que ces articles seront acceptés et dans leur forme définitive.
Nous espérons que ceci permettra aux scientifiques du monde entier de suivre les travaux que nous menons dans cette situation épidémique.
The IHU pre-publication site on COVID-19
Given the speed of evolution of the epidemic and the permanent information needs of the scientific community, combined with the difficulty of travel, the foundation has decided to put online the submitted articles (preprint), as have already started to do the sites but which in the current situation have deadlines too important to be compatible with the need for speed that we have.
As of today, all the publications that we will submit will be put in preprint on our site and will be replaced by a link to an official scientific publication, as soon as these articles are accepted and in their final form.
We hope that this will allow scientists around the world to follow our work in this epidemic situation.
COVID-IHU #37
Version 1 du 14 septembre 2020
Daytime variation in SARS-CoV-2 infection and cytokine production
Aissatou Bailo Diallo, Laetitia Gay, Benjamin Coiffard, Marc Leone, Soraya Mezouar, Jean-Louis Mège
Lien vers l’article : https://www.biorxiv.org/content/10.1101/2020.09.09.290718v1
COVID-IHU #29
Version 1 du 25 Août 2020
Nullane salus extra ecclesiam
Philippe Gautret, Didier Raoult
Lien vers l’article : https://www.sciencedirect.com/science/article/pii/S2052297520300664
COVID-IHU #20
Version 1 du 29 Juin 2020
Culture of SARS-CoV-2 in a panel of laboratory cell lines
Nathalie Wurtz, Gwilherm Penant, Priscilla Jardot, Nathalie Duclos and Bernard La Scola
COVID-IHU #19
Version 1 du 10 Juin 2020
Open screening of SARS-CoV-2 infections in the pediatric population in Marseille, Southern France
Aurélie Morand, PhD, MD1,2*, Tatiana Matteudi1, Alexandre Fabre, PhD, MD3,4, Philippe Minodier, MD5, Emmanuelle Bosdure, MD1, Léa Luciani, PharmD2, Jean-Christophe Dubus, PhD, MD1,6, Matthieu Million, PhD, MD2,6, Hervé Tissot-Dupont, MD2,6, Bernard La Scola, PhD, MD2,6, Philippe Colson, PhD, PharmD2,6, Didier Raoult, PhD, MD2,6, Brigitte Chabrol, PhD, MD1
In this cohort study we reported the first 302 pediatric SARS-CoV-2-positive patients in Marseille, mainly diagnosed thanks to open screening platform (80%).
COVID-IHU #15
Version 1 du 27 Mai 2020
Early diagnosis and management of COVID-19 patients: a real-life cohort study of 3,737 patients, Marseille, France
Cet article a été accepté par le journal Travel Medicine and Infectious Diseases, sous le titre : « Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: a retrospective analysis« .
Il sera disponible online dans de courts délais.
COVID-IHU #6
Early treatment of 1061 COVID-19 patients with hydroxychloroquine and azithromycin, Marseille, France
Matthieu Million, Jean-Christophe Lagier, Philippe Gautret, Philippe Colson, Pierre-Edouard Fournier, Sophie Amrane, Marie Hocquart, Morgane Mailhe, Vera Esteves-Vieira, Barbara Doudier, Camille Aubry, Florian Correard, Audrey Giraud-Gatineau, Yanis Roussel, Cyril Bellenger, Nadim Cassir, Piseth Seng, Christine Zandotti, Catherine Dhiver, Isabelle Ravaux, Christelle Tomei, Carole Eldin, David Braunstein, Hervé Tissot-Dupont, Stéphane Honoré, Andreas Stein, Alexis Jacquier, Jean-Claude Deharo, Eric Chabrière, Anthony Levasseur, Florence Fenollar, Jean-Marc Rolain, Yolande Obadia, Philippe Brouqui, Michel Drancourt, Bernard La Scola, Philippe Parola, Didier Raoult
COVID-IHU #4
Version 3 du 17 avril 2020
In vitro testing of combined Hydroxychloroquine and Azithromycin on SARS-CoV-2 shows synergistic effect
Julien Andreani, Marion Le Bideau, Isabelle Duflot, Priscilla Jardot, Clara Rolland, Manon Boxberger, Jacque Yaacoub Bou Khalil, Jean-Pierre Baudouin, Nathalie Wurtz, Jean-Marc Rolain, Philippe Colson, Bernard La Scola, Didier Raoult
Lien vers l’article online : https://doi.org/10.1016/j.micpath.2020.104228
COVID-IHU #3
Version 1 du 27 mars 2020
Children account for a small proportion of diagnoses of SARS-CoV-2 infection and do not exhibit greater viral loads than adults
Philippe COLSON, Hervé TISSOT-DUPONT, Aurélie MORAND, Céline BOSCHI, Laetitia NINOVE, Vera ESTEVES-VIERA, Philippe GAUTRET, Philippe BROUQUI, Philippe PAROLA, Jean-Christophe LAGIER, Christine ZANDOTTI, Matthieu MILLION, Bernard LA SCOLA, Didier RAOULT
COVID-IHU #2
Version 1 du 27 mars 2020
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: an observational study
Philippe Gautret, Jean-Christophe Lagier, Philippe Parola, Van Thuan Hoang, Line Meddeb, Jacques Sevestre , Morgane Mailhe, Barbara Doudier , Camille Aubry, Sophie Amrane, Piseth Seng, Marie Hocquart, Julie Finance, Vera Esteves Vieira, Hervé Tissot Dupont, Stéphane Honoré, Andreas Stein, Matthieu Million, Philippe Colson, Bernard La Scola, Véronique Veit, Alexis Jacquier, Jean-Claude Deharo, Michel Drancourt, Pierre Edouard Fournier, Jean-Marc Rolain, Philippe Brouqui, Didier Raoult
COVID-IHU #1
Version 1 du 26 mars 2020
Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards
Bernard La Scola, Marion Le Bideau, Julien Andreani, Van Thuan Hoang, Clio Grimaldier, Philippe Colson, Philippe Gautret, Didier Raoult
COVID-IHU #36
Version 1 du 11 septembre 2020
COVID-19 in Africa: What else ?
Philippe Parola, Souleymane Brah, Abdoulaye Djimde, Nadjet Mouffok, Majida Zahraoui, Ali Ould Mohamed Salem Boukhary, Idir Bitam, Mahamadou Ali Thera, Jean-Bernard Lekana-Douki, Eric Adehossi, Moussa Seydi, Jean-Christophe Lagier, Jaafar Heikel, Didier Raoult, Cheikh Sokhna
As recent news or groundbreaking work, the factors which may explain the dampened course of COVID-19 in Africa has been recently discussed in Science (7 August 2020, p 624-626) but we think that a major issue is missing.
We, being Professors of Infectious diseases or microbiology, MD, PhD, coauthors from Algeria, Morocco, Senegal, Niger, Mali, Mauritania, Gabon, and France, all involved in the COVID 19 pandemic in Africa, would like to comment their article with this PERSPECTIVE to JMII discussing the potential role of the large use of chloroquine derivative with or without azithromycin in many African countries, including ours.
COVID-IHU #35
Version 1 du 08 septembre 2020
High prevalence of Lupus Anticoagulant in Ambulatory COVID-19 patients: interest of Hydroxychloroquine ?
Laurence Camoin-Jau, Philippe Gautret, Philippe Colson, Jean Christophe Lagier, Hervé Tissot-Dupont, Matthieu Million, Audrey Giraud-Gatineau, Sophia Boudjema, Hervé Chaudet, Didier Raoult
COVID-IHU #34
Version 1 du 07 septembre 2020
Dramatic increase in the SARS-CoV-2 mutation rate and low mortality rate during the second epidemic in summer in Marseille
Philippe COLSON, Anthony LEVASSEUR, Jeremy DELERCE, Hervé CHAUDET, Vincent BOSSI, Mariem BEN KHEDHER, Pierre-Edouard FOURNIER, Jean-Christophe LAGIER, Didier RAOULT
COVID-IHU #33
Version 1 du 07 septembre 2020
Temporal and age distributions of SARS-CoV-2 and other coronaviruses, Southeastern France
Philippe COLSON, Vera ESTEVES-VIEIRA, Audrey GIRAUD-GATINEAU, Christine ZANDOTTI, Véronique FILOSA, Hervé CHAUDET, Jean-Christophe LAGIER, Didier RAOULT
COVID-IHU #32
Version 1 du 07 septembre 2020
Genomic diversity and evolution of coronavirus (SARS-CoV-2) in France from 309 COVID-19-infected patients
Anthony LEVASSEUR, Jeremy DELERCE, Aurelia CAPUTO, Ludivine BRECHARD, Philippe COLSON, Jean-Christophe LAGIER, Pierre-Edouard FOURNIER, Didier RAOULT
COVID-IHU #25
Version 1 du 08 Juillet 2020
Hydroxychloroquine and Azithromycin as a Treatment of COVID-19: Results of an Open-Label Non-Randomized Clinical Trial: Response to David Spencer (Elsevier)
Didier Raoult1,2, Matthieu Million1,2, Philippe Gautret1,3, Jean-Christophe Lagier1,2, Philippe Colson1,2, Philippe Parola1,3, and Jean-Marc Rolain1,2
COVID-IHU #23
Version 1 du 30 juin 2020
Hydroxychloroquine recommendations toward the world : first evaluations
Yanis ROUSSEL, Didier RAOULT
COVID-IHU #22
Version 1 du 30 juin 2020
Does IHU Mediterranean Infection influence Gilead stock price ?
Eric Chabrière
COVID-IHU #21
The Lancet COVID-19 therapy study : another miss-out
Dragan Pavlovic
COVID-IHU #18
Version 2 du 18 Juin 2020
Randomised Controlled Trials during epidemic
Philippe Brouqui, Didier Raoult
In epidemics there is an urgent need for new knowledge on drug efficacy to help policymakers fight the crisis. Yet the best research methodology to do this is a matter of debate, write Philippe Brouqui and Didier Raoult.
COVID-IHU #17
Version 1 du 08 Juin 2020
Adjusting series of patients for trial comparisons for COVID-19 treatments
Audrey GIRAUD-GATINEAU, Jean-Christophe LAGIER, Yolande OBADIA, Hervé CHAUDET, Didier RAOULT
COVID-IHU #31
Version 1 du 1er septembre 2020
Differences pattern of the second outbreak of COVID-19 in Marseille, France
Philippe Gautret, Philippe Colson, Jean Christophe Lagier, Laurence Camoin-Jau, Audrey Giraud-Gatineau, Sophia Boudjema, Hervé Chaude, Didier Raoult
COVID-IHU #30
Version 1 du 1er septembre 2020
Re: Effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients : a systematic review and meta-analysis
Matthieu MILLION, Yanis ROUSSEL, Jean-Christophe LAGIER, Didier RAOULT
COVID-IHU #28
Version 1 du 21 août 2020
Quousque tandem abutere, patientia nostra – Article soumis et rejeté par The New England Journal of Medecine
Didier Raoult, M.D, Ph.D., Jean-Christophe Lagier M.D, Ph.D., Philippe Brouqui, M.D., Ph.D., Philippe Parola, M.D, Ph.D.
COVID-IHU #27
Version 2 du 21 août 2020
Pattern of SARS-CoV-2 infection among dependant elderly residents living in retirement homes in Marseille, France, March-June 2020
Tran Duc Anh Ly, Didier Zanini, Vincent Laforge, Sylvie Arlotto, Stephanie Gentile, Helene Mendizabal, Michaël Finaud, David Morel, Olivier Quenette, Priscilla Malfuson-Clot-Faybesse, Alain Midejean, Phuc Le-Dinh, Gérard Daher, Berengere Labarriere, Anne-Marie Morel-Roux, Alain Coquet, Patrick Augier, Philippe Parola, Eric Chabriere, Didier Raoult, Philippe Gautret
COVID-IHU #26
Version 1 du 17 août 2020
Olfactory and gustative disorders for the diagnosis of COVID-19
Sophia Boudjema, Julie Finance, Fatoumata Coulibaly, Line Meddeb, Hervé Tissot-Dupont, Moïse Michel, Jean Christophe Lagier, Matthieu Million, Thomas Radulesco, Justin Michel, Philippe Brouqui, Didier Raoult, Florence Fenollar, Philippe Parola
COVID-IHU #24
Version 1 du 30 juin 2020
Remdesivir investigational trials in COVID-19: a critical reappraisal
P Brouqui, A Giraud-Gatineau & D Raoult
Lire l’article
Lettre à l’éditeur
Answer to reviewer’s comment and editor
COVID-IHU #16
Version 1 du 04 juin 2020
Predictive values of olfactory and gustative disorders for the diagnosis of COVID-19: a cohort of 3,497 patients and 432 healthcare workers
Sophia Boudjema, Julie Finance, Fatoumata Coulibaly, Line Meddeb, Hervé Tissot-Dupont, Moïse Michel, Jean Christophe Lagier, Matthieu Million, Thomas Radulesco, Justin Michel, Philippe Brouqui, Didier Raoult, Florence Fenollar, Philippe Parola
COVID-IHU #14
Version 1 du 14 Mai 2020
High speed large scale automated isolation of SARS-CoV-2 from clinical samples using miniaturized co-culture coupled with high content screening
Rania Francis, Marion Le Bideau, Priscilla Jardot, Clio Grimaldier, Raoult Didier, Jacques Yaacoub Bou Khalil and Bernard La Scola
COVID-IHU #13
Version 1 du 14 Mai 2020
The strengths of scanning electron microscopy in deciphering SARS-CoV-2 infectious cycle
Djamal Brahim Belhaouari, Anthony Fontanini, Jean-Pierre Baudoin, Gabriel Haddad, Marion Le Bideau, Jacques Yaacoub Bou Khalil, Didier Raoult, Bernard La Scola
Lien vers l’article : https://www.frontiersin.org/articles/10.3389/fmicb.2020.02014/full
COVID-IHU #12
Version 1 du 13 Mai 2020
Screening of SARS-CoV-2 among homeless people, asylum-seekers and other people living in precarious conditions in Marseille, France, March–April 2020.
Tran Duc Anh Ly, Van Thuan Hoang, Ndiaw Goumballa, Meriem Louni, Naomie Canard, Thi Loi Dao, Hacene Medkour, Audrey Borg, Kevin Bardy, Véra EstevesVieira, Véronique Filosa, Bernard Davoust, Oleg Mediannikov, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret
COVID-IHU #11
Version 1 du 04 Mai 2020
Evaluating the serological status of COVID-19 patients using an indirect immunofluorescent assay, France
S. Edouard, P. Colson, C. Melenotte, F. De Pinto, L. Thomas, B. La Scola, M. Million, H. Tissot-Dupont, P. Gautret, A. Stein, P. Brouqui, P. Parola, J-C Lagier, D. Raoult, M. Drancourt
COVID-IHU #10
Version 1 du 30 avril 2020
The efficacy of Chloroquine derivatives in COVID-19: a meta-analysis based on the first available reports
Matthieu Million, Philippe Gautret, Didier Raoult
Version 2 du 07 mai 2020
The efficacy of Chloroquine derivatives in COVID-19: a meta-analysis based on the first available reportsMatthieu MILLION, Philippe GAUTRET, Philippe COLSON, Yanis ROUSSEL, Gregory DUBOURG, Florence FENOLLAR, Pierre-Edouard FOURNIER, Jean-Marc ROLAIN, Jean-Christophe LAGIER, Philippe PAROLA, Philippe BROUQUI, Didier RAOULT
COVID-IHU #9
Version 1 du 22 avril 2020
Combination of hydroxychloroquine plus azithromycin as potential treatment for COVID 19 patients: pharmacology, safety profile, drug interactions and management of toxicity.
Guillaume Hache, Jean Marc Rolain, Philippe Gautret, JeanClaude Deharo, Philippe Brouqui, Didier Raoult, Stéphane Honoré
COVID-IHU #8
Version 1 du 22 avril 2020
Response to Magagnoli, MedRxiv, 2020
Matthieu MILLION, Yanis ROUSSEL, Didier RAOULT
COVID-IHU #7
Version 1 du 14 avril 2020
In vitro antiviral activity of doxycycline against SARS-CoV-2
Matthieu Gendrot, Julien Andreani, Priscilla Jardot, Sébastien Hutter, Manon Boxberger, Joel Mosnier, Marion Le Bideau, Isabelle Duflot, Isabelle Fonta, Clara Rolland, Hervé Bogreau, Bernard La Scola, Bruno Pradines
COVID-IHU #5
Version 2 du 30 mars 2020
Decreased mortality associated with respiratory viral infections between December 2019 and March 2020 compared to previous year, Southeast France
Audrey GIRAUD-GATINEAU, Philippe COLSON, Marie-Thérèse JIMENO, Christine ZANDOTTI, Laetitia NINOVE, Céline BOSCHI, JeanChristophe LAGIER, Bernard LA SCOLA, Hervé CHAUDET, Didier RAOULT
