Le site des publications & des preprint de l’IHU sur le COVID-19

Compte-tenu de la vitesse d’évolution de l’épidémie et des besoins de renseignements permanents pour la communauté scientifique, associé à la difficulté des déplacements, la fondation a décidé de mettre online les articles soumis (preprint), comme ont déjà commencé à le faire les sites mais qui dans la situation actuelle ont des délais trop importants pour être compatibles avec les besoins de rapidité que nous avons.

Dès aujourd’hui, toutes les publications que nous soumettrons seront mises en preprint sur notre site et seront remplacées par un lien vers une publication scientifique officielle, dès que ces articles seront acceptés et dans leur forme définitive.

Nous espérons que ceci permettra aux scientifiques du monde entier de suivre les travaux que nous menons dans cette situation épidémique.

The IHU publication and pre-publication site on COVID-19

Given the speed of evolution of the epidemic and the permanent information needs of the scientific community, combined with the difficulty of travel, the foundation has decided to put online the submitted articles (preprint), as have already started to do the sites but which in the current situation have deadlines too important to be compatible with the need for speed that we have.

As of today, all the publications that we will submit will be put in preprint on our site and will be replaced by a link to an official scientific publication, as soon as these articles are accepted and in their final form.

We hope that this will allow scientists around the world to follow our work in this epidemic situation.

NUMÉRO SPÉCIAL IHU

Version 1 du 8 février 2021
Two-millennia fighting against port-imported epidemics, Marseille
Barbieri, R, Colson, P., Raoult, D., Drancourt, M

Link to the article
Figure1

DOI : https://doi.org/10.35088/84a4-me41

Version 1 du 8 février 2021
What neo semeiology brings to the care of patient with COVID-19
Philippe Brouqui MD, PhD, Carole Eldin MD, PhD, Sophia Boudjema RN PhD & Didier Raoult MD PhD

Link to the article
BROUQUI Neosemiology Table
BROUQUI Neosemiology Panel
Brouqui Neosemiology Figure

DOI : https://doi.org/10.35088/83h6-zj15

Version 1 du 8 février 2021
Consequences of the COVID-19 outbreak on the diversity of non-viral infectious agents and the evolution of antibiotic resistance by using a syndromic surveillance based on laboratory data at the IHU Méditerranée Infection, Marseille, France
Lancei KABA, Audrey GIRAUD-GATINEAU, Marie-Thérèse JIMENO, Jean-Marc ROLAIN, Philippe COLSON, Didier RAOULT, Hervé CHAUDET

Link to the article
tables
Cover_letter
Figures

DOI : https://doi.org/10.35088/sgnn-cx42

Version 1 du 8 février 2021
Epidemiological surveillance of respiratory viral infections at IHU Méditerranée Infection and its application to SARS-CoV-2
Philippe COLSON, Audrey GIRAUD-GATINEAU, Pierre-Edouard FOURNIER, Laetitia NINOVE, Christine ZANDOTTI, Marie-Thérèse JIMENO, Céline BOSCHI, Léa LUCIANI, Lancei KABA, Philippe PAROLA, Stéphane RANQUE, Jean-Marc ROLAIN, Philippe GAUTRET, Michel DRANCOURT, Jean-Christophe LAGIER, Bernard LA SCOLA, Hervé CHAUDET, Didier RAOULT

Link to the article
Figures
CL_IHU_Colson_Raoult_Jan2021vD

DOI : https://doi.org/10.35088/gpgh-wq98

Version 1 du 8 février 2021
Point-of-care diagnosis of COVID-19 at IHU Méditerranée Infection, Marseille, France
A. Bouam, M. Boualam, P-Y. Levy, S. Honoré, B. La Scola, P-E. Fournier, D. Raoult, M. Drancourt,

Link to the article
IHU_Bouam_Drancourt_Jan2021vD
Supplementary tables
Figures
SupplFigures

DOI : https://doi.org/10.35088/vjys-2d88

Version 1 du 8 février 2021
In vitro Evaluation of the Antiviral Activity of Repurposable Drugs against SARS-CoV- 2 : Methylene Blue
Mathieu Gendrot, Priscilla Jardot, Océane Delandre, Manon Boxberger, Julien Andreani, Isabelle Duflot, Marion Le Bideau, Joel Mosnier, Isabelle Fonta, Sébastien Hutter, Bernard La Scola and Bruno Pradines

Link to the article
Cover letter
Figures

DOI : https://doi.org/10.35088/nzhj-jd72

Version 1 du 8 février 2021
Genome sequence analysis enabled deciphering the atypical evolution of COVID-19 epidemics in Marseille, France
Pierre-Edouard FOURNIER, Philippe COLSON, Anthony LEVASSEUR, Philippe GAUTRET, Marielle BEDOTTO, Véronique FILOSA, Jeremy DELERCE, Ludivine BRECHARD, Jean-Christophe LAGIER, Hervé CHAUDET, Florence FENOLLAR, Didier RAOULT

Link to the article
SUPPLEMENTARY MATERIAL 04-01-2020
Cover letter
Figures

DOI : https://doi.org/10.35088/kmct-tj43

Version 1 du 8 février 2021
Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates 
Céline Boschi, Marion Le Bideau , Julien Andreani, Sarah Aherfi, Priscilla Jardot, Jeremy Delerce,  Mathieu Gendrot, Bruno Pradines, Philippe Colson, Didier Raoult, Anthony Levasseur, Bernard La Scola

Link to the article
CoverLetter
Supplementary table 1
Figures
Article Boschi et al

DOI : https://doi.org/10.35088/x0dw-qn84

Version 1 du 8 février 2021
Evolution of the management of COVID-19
Jean-Christophe Lagier, Matthieu Million, Laurence Camoin-Jau, Carole Eldin, Grégory Dubourg, Hervé Tissot-Dupont, Didier Raoult, Philippe Brouqui and Philippe Parola

Link to the article
Figures
Cover letter Lagier 20012021

DOI : https://doi.org/10.35088/ppdz-8857

Version 1 du 8 février 2021
Predictive Factors of Clinical Assays during COVID-19
Matthieu MILLION, Pierre DUDOUET, Eric CHABRIERE, Sébastien CORTAREDONA, Philippe BROUQUI, Didier RAOULT

Link to the article
Cover letter
Figures
Supplementary data
Supplementary file

DOI : https://doi.org/10.35088/aam9-bg48

Version 1 du 8 février 2021
COVID-19 in Africa : What else ?
Cheikh Sokhna, Souleymane Brah, Abdoulaye Djimde, Nadjet Mouffok, Majida Zahraoui, Ali Ould Mohamed Salem Boukhary, Idir Bitam, Badara Cisse,  Mahamadou Ali Thera, Jean-Bernard Lekana-Douki, Eric Adehossi, Moussa Seydi, Jean Akiana, Jaafar Heikel, Jean-Christophe Lagier, Souleymane Mboup,  Jean-Jacques Mouyembe-Tamfum, Philippe Parola

Link to the article
CoverLetter

DOI : https://doi.org/10.35088/wsh3-kx83

Version 1 du 8 février 2021
New Institute to fight threats: the COVID-19 paradigm
Brouqui P., Drancourt M., Raoult D

Link to the article
Table 1
Organigramme
Fig1
CL_IHU_Raoult_Jan2021vD

DOI : https://doi.org/10.35088/p2qz-mk63

Version 1 du 8 février 2021
Impact of COVID-19 over Infectious Diseases publications, 2020
Roussel, Y., Ouanezar, A., Grine, G.

Link to the article
Cover Letter Roussel

DOI : https://doi.org/10.35088/p2qz-mk63

Version 1 du 8 février 2021
How is built the “legitimate information”on the Covid crisis
Laurent MUCCHIELLI

Link to the article
Cover letter

DOI : ttps://doi.org/10.35088/2vgx-r470

CLINICAL OBSERVATIONAL STUDIES AND COHORTS

Version 2 du 4 juin 2021
Outcomes of 2,111 COVID-19 hospitalised patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: a monocentric retrospective analysis
Jean-Christophe Lagier, Matthieu Million, Sébastien Cortaredona, Sophie Amrane, Camille Aubry, Anne Darmon, Barbara Doudier, Pierre Dudouet,  Marie Hocquart, Morgane Mailhe, Justine Raclot, Piseth Seng, Léa Delorme, Stéphanie Gentile, Sylvie Arlotto, Audrey Giraud-Gatineau,  Laurence Camoin-Jau, Philippe Gautret, Herve Tissot-Dupont, Cyril Berenger, Philippe Colson, Pierre-Edouard Fournier, Florence Fenollar, Baptiste Maille, Alexis Jacquier, Stéphane Honore, Yolande Obadia, Andreas Stein, Philippe Brouqui, Philippe Parola, Didier Raoult

Link to the article

DOI : https://doi.org/10.35088/mpnh-st89

Version 1 du 12 mai 2021
Early Treatment with Hydroxychloroquine and Azithromycin in 10,429 COVID-19 Outpatients: A Monocentric Retrospective Cohort Study
Matthieu MILLION, MD, PhD, Jean-Christophe LAGIER, MD, PhD, Herve TISSOT-DUPONT, MD, Isabelle RAVAUX, MD, Catherine DHIVER, MD, Christelle TOMEI, MD, Nadim CASSIR, MD, PhD, Léa DELORME, MS, Sébastien CORTAREDONA, PhD, Stéphanie GENTILE, MD, PhD, Elisabeth JOUVE, MD, Audrey GIRAUD-GATINEAU, Herve CHAUDET, MD, PhD, Laurence CAMOIN-JAU, MD, PhD, Philippe COLSON, PharmD, PhD, Philippe GAUTRET, MD, PhD, Pierre-Edouard FOURNIER, MD, PhD, Baptiste MAILLE, MD, Jean-Claude DEHARO, MD, PhD, Paul HABERT, MD, Jean-Yves GAUBERT, MD, PhD, Alexis JACQUIER, MD, PhD, Stéphane HONORE, PharmD, PhD, Katell GUILLON-LORVELLEC, PharmD, Yolande OBADIA, MD, PhD, Philippe PAROLA, MD, PhD, Philippe BROUQUI, MD, PhD, Didier RAOULT, MD, PhD, IHU COVID-19 Task Force

Link to the article
Supplementary data
Figures

DOI : https://doi.org/10.35088/vadm-jx92

Version 1 du 18 février 2021
High-flow oxygen therapy in elderly patients infected with SARS-CoV2 with a contraindication for transfer to an intensive care unit
Jean-Christophe Lagier, Sophie Amrane, Morgane Mailhe, Marc Gainnier, Sylvie Arlotto, Stéphanie Gentile and Didier Raoult

Link to the article

Version 1 du 15 février 2021
Immature neutrophils and high anti-SARS-CoV-2 IgG levels are hallmarks of severe and critical COVID-19 infection
C. Melenotte, JC. Lagier, M. Million, M. Gainnier, S. Edouard, L. Zitvogel, P. Colson, JL Mège, P. Parola, M. Drancourt, D. Raoult

Link to the article
Figure1,2,3

DOI : https://doi.org/10.35088/mbb9-z836

Version 1 du 15 février 2021
FDG-PET/CT revealing aortic hypermetabolism in patients with chest pain after COVID-19: a retrospective study
Pierre Dudouet, Serge Cammilleri, Alexis Jacquier, Eric Guedj, Didier Raoult, Carole Eldin

Link to the article
Figure1
Figure2

DOI : https://doi.org/10.35088/tzz0-jn64

Version 1 du 28 janvier 2021
Predictive Factors of Clinical Assays during COVID-19
Matthieu MILLION, Pierre DUDOUET, Eric CHABRIERE, Sébastien CORTAREDONA, Philippe BROUQUI, Didier RAOULT

Link to the article
Supplementary data
Supplementary file
Figure 1
Figure 2

DOI : https://doi.org/10.35088/s7fz-r784

Version 1 du 24 novembre 2020
Re: Covid-19: politicisation, “corruption,” and suppression of science
Matthieu MILLION, Didier RAOULT

Link to the article

Version 1 du 13 Mai 2020
Screening of SARS-CoV-2 among homeless people, asylum-seekers and other people living in precarious conditions in Marseille, France, March–April 2020.
Tran Duc Anh Ly, Van Thuan Hoang, Ndiaw Goumballa, Meriem Louni, Naomie Canard, Thi Loi Dao, Hacene Medkour, Audrey Borg, Kevin Bardy, Véra EstevesVieira, Véronique Filosa, Bernard Davoust, Oleg Mediannikov, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret

Link to the article

Version 1 du 08 Juin 2020
Adjusting series of patients for trial comparisons for COVID-19 treatments
Audrey GIRAUD-GATINEAU, Jean-Christophe LAGIER, Yolande OBADIA, Hervé CHAUDET, Didier RAOULT

DOI : https://doi.org/10.35088/fk6j-n864

Link to the article

Version 1 du 22 avril 2020
Response to Magagnoli, MedRxiv, 2020
Matthieu MILLION, Yanis ROUSSEL, Didier RAOULT

Link to the article

Version 1 du 22 avril 2020
Combination of hydroxychloroquine plus azithromycin as potential treatment for COVID 19 patients: pharmacology, safety profile, drug interactions and management of toxicity.
Guillaume Hache, Jean Marc Rolain, Philippe Gautret, JeanClaude Deharo, Philippe Brouqui, Didier Raoult, Stéphane Honoré

Link to the article

Version 1 du 24 septembre 2020
Hydroxychloroquine and Azithromycin as a Treatment of COVID-19: Results of an Open-Label Non-Randomized Clinical Trial: Response to criticisms
Didier Raoult, Matthieu Million, Jean-Christophe Lagier, Philippe Colson, Philippe Parola, Jean-Marc Rolain, Philippe Gautret

Link to the article
Figure 1A
Figure 1B
Supplement data

DOI : https://doi.org/10.35088/bjjr-cy47

Version 1 du 1er septembre 2020
Re: Effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients : a systematic review and meta-analysis
Matthieu MILLION, Yanis ROUSSEL, Jean-Christophe LAGIER, Didier RAOULT

Lire l’article

DOI : https://doi.org/10.35088/2s5m-dh47

GENOMICS

Version 1 du 21 juillet
Limited spread of a rare spike E484K-harboring SARS-CoV-2 in Marseille, France
Philippe COLSON, Jacques FANTINI, Nouara YAHI, Jeremy DELERCE, Anthony LEVASSEUR, Pierre-Edouard FOURNIER, Jean-Christophe LAGIER, Didier RAOULT, Bernard LA SCOLA

Link to the article
DOI : https://doi.org/10.35088/2ngw-sa32

Version 1 du 25 juin
Occurrence of a substitution or deletion of SARS-CoV-2 spike amino acid 677 in various lineages in Marseille, France
Philippe COLSON, Jeremy DELERCE, Emilie BUREL, Mamadou BEYE, Pierre-Edouard FOURNIER, Anthony LEVASSEUR, Jean-Christophe LAGIER, Didier RAOULT

Link to the article

Version 1 du 30 avril 2021
SARS-CoV-2 variant from India to Marseille: the still active role of ports in the introduction of epidemics
Bernard LA SCOLA, Pierre-Edouard FOURNIER, Philippe COLSON, Alexandre LACOSTE, Didier RAOULT

Link to the article

DOI : https://doi.org/10.35088/1n5j-qn47

Version 1 du 5 mars 2021
Spreading of a new SARS-CoV-2 N501Y spike clone in a new lineage.
Philippe COLSON, Anthony LEVASSEUR, Jeremy DELERCE, Lucile PINAULT, Pierre DUDOUET, Christian DEVAUX, Pierre-Edouard FOURNIER, Bernard LA SCOLA, Jean-Christophe LAGIER, Didier RAOULT

Link to the article
Figure 1
Figure 2
Figure 3

DOI : https://doi.org/10.35088/4y1e-ec62

Version 1 du 20  février 2021
Global discrepancies between numbers of available SARS-CoV-2 genomes and human 6 development indexes at country scales
Philippe COLSON, Didier RAOULT

Link to the article

DOI : https://doi.org/10.35088/tny6-v454

Version 1 du 15  février 2021
LamPORE SARS-CoV-2 diagnosis and genotyping: a preliminary report
Morsli, M. Anani, H., Bréchard, L., Delerce, J.,  Bedotto, M., Fournier, P.-E., Drancourt, M.

Link to the article 

DOI : https://doi.org/10.35088/zkvc-5s65

Version 1 du 12 février 2021
Implementation of an in-house real-time reverse transcription-PCR assay to detect the emerging SARS-CoV-2 N501Y variants
Marielle BEDOTTO, Pierre-Edouard FOURNIER, Linda HOUHAMDI, Philippe COLSON, Didier RAOULT

Link to the article

DOI : https://doi.org/10.1101/2021.02.03.21250661

 

Version 1 du 8 février 2021
Viral RNA in city wastewater as a key indicator of COVID-19 recrudescence and containment measures effectiveness
Nathalie Wurtz, Alexandre Lacoste, Priscilla Jardot, Alain Delache, Xavier Fontaine, Maxime Verlande, Alexandre Annessi, Audrey Giraud-Gatineau, Pierre-Edouard Fournier, Patrick Augier, Bernard La Scola

Link to the article

DOI : https://doi.org/10.35088/53pr-da73

Version 1 du 8 février 2021
Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates
Celine Boschi, Marion Le Bideau, Julien Andreani, Sarah Aherfi, Priscilla Jardot, Jeremy Delerce, Mathieu Gendrot, Bruno Pradines, Philippe Colson, Didier Raoult, Anthony Levasseur, Bernard La Scola

Link te the article

Version 1 du 2 février 2021
Genome sequence analysis enabled deciphering the atypical evolution of COVID-19 epidemics in Marseille, France
Pierre-Edouard FOURNIER, Philippe COLSON, Anthony LEVASSEUR, Philippe GAUTRET, Marielle BEDOTTO, Véronique FILOSA, Jeremy DELERCE, Ludivine BRECHARD, Jean-Christophe LAGIER, Hervé CHAUDET, Florence FENOLLAR, Didier RAOULT

Link to the article
SUPPLEMENTARY MATERIAL

doi: https://doi.org/10.35088/8q4t-hf73

Version 2 du 22 mars 2021
Emergence and outcome of the SARS-CoV-2 “Marseille-4” variant
Pierre-Edouard FOURNIER, Philippe COLSON, Anthony LEVASSEUR, Christian DEVAUX, Philippe GAUTRET, Marielle BEDOTTO, Jeremy DELERCE, Ludivine BRECHARD, Lucile PINAULT, Jean-Christophe LAGIER, Florence FENOLLAR, Didier RAOULT

Link to the article

doi: https://doi.org/10.35081/xcrm-6t77

Version 1 du 07 septembre 2020
Dramatic increase in the SARS-CoV-2 mutation rate and low mortality rate during the second epidemic in summer in Marseille
Philippe COLSON, Anthony LEVASSEUR, Jeremy DELERCE, Hervé CHAUDET, Vincent BOSSI, Mariem BEN KHEDHER, Pierre-Edouard FOURNIER, Jean-Christophe LAGIER, Didier RAOULT

Link to the article

doi: https://doi.org/10.35088/68c3-ew82

IMMUNOLOGY

Version 1 du 22 mars 2021
Current status of putative animal sources of SAS-CoV-2 infection in humans: wildlife, domestic animals and pets
Max Maurin, Florence Fenollar, Oleg Mediannikov, Bernard Davoust, Christian Devaux, and Didier Raoult

Link to the article

DOI :

Version 1 du 12 février 2021
Automated Western immunoblotting detection of anti-SARS-CoV-2 serum antibodies
Sophie Edouard, Rita Jaafar, Nicolas Orain, Philippe Parola, Philippe Colson, Bernard La Scola, Pierre-Edouard Fournier, Didier Raoult, Michel Drancourt

Link to the article
Tables

DOI : https://doi.org/10.35088/j13t-az32

Version 1 du 08 septembre 2020
High prevalence of Lupus Anticoagulant in Ambulatory COVID-19 patients: interest of Hydroxychloroquine ?
Laurence Camoin-Jau, Philippe Gautret, Philippe Colson, Jean Christophe Lagier, Hervé Tissot-Dupont, Matthieu Million, Audrey Giraud-Gatineau, Sophia Boudjema, Hervé Chaudet, Didier Raoult

Link to the article

DOI : https://doi.org/10.35088/4spd-6q49

Version 1 du 14 septembre 2020
Daytime variation in SARS-CoV-2 infection and cytokine production
Aissatou Bailo Diallo, Laetitia Gay, Benjamin Coiffard, Marc Leone, Soraya Mezouar, Jean-Louis Mège

Link to the article : https://www.biorxiv.org/content/10.1101/2020.09.09.290718v1

Version 1 du 21 septembre 2020
Monocytes and macrophages, targets of SARS-CoV-2: the clue for Covid-19 immunoparalysis
Asma Boumaza, Laetitia Gay, Soraya Mezouar, Aïssatou Bailo Diallo, Moise Michel1,2, Benoit Desnues1,2, Didier Raoult1,2, Bernard La Scola1,2, Philippe Halfon, Joana Vitte, Daniel Olive and Jean-Louis Mege

Link to the article

DIAGNOSTIC

Version 1 du 11 mars  2021
SARS-CoV2 persistent viral shedding 1 in the context of hydroxychloroquine azithromycin treatment
Michel Drancourt, Sébastien Cortaredona, Cléa Melenotte, Sophie Amrane, Carole Eldin, Bernard La Scola, Philippe Parola, Matthieu Million, Jean-Christophe Lagier, Didier Raoult, Philippe Colson

Link to the article

DOI : https://doi.org/10.35088/xjkb-7e30

Version 1 du 08 mars  2021
A possible role of COVID-19 therapy in the selective sweep and emergence of new SARS-CoV-2 variants
Philippe COLSON, Christian A DEVAUX and Didier RAOULT

Link to the article
Figure

DOI : https://doi.org/10.35088/x7hb-nx89

Version 1 du 12 février 2021
Pipeline for drug repurposing of FDA-approved drugs against SARS-CoV-1 and SARS-CoV-2
Sarah Aherfi, Bruno Pradines, Christian Devaux, Stéphane Honore, Philippe Colson, Bernard La Scola, Didier Raoult

Link to the article
Figure1
Figure2
Figure3

DOI : https://doi.org/10.35088/0wxq-hj16

Version 1 du 3 février 2021
Cyclosporin A: a repurposable drug in the treatment of COVID-19 ?
Christian A. DEVAUX, Cléa MELENOTTE, Marie-Dominique PIERCECCHI-MARTI, Clémence DELTEIL, and Didier RAOULT

Link to the article

DOI : https://doi.org/10.35088/aett-j123

Version 2 du 24 septembre 2020
Evaluating the serological status of COVID-19 patients using an indirect immunofluorescent assay, France
S. Edouard, P. Colson, C. Melenotte, F. De Pinto, L. Thomas, B. La Scola, M. Million, H. Tissot-Dupont, P. Gautret, A. Stein, P. Brouqui, P. Parola, J-C Lagier, D. Raoult, M. Drancourt

Link to the article
Figures 1-2-3-4-S1
Tables 1 et 2

Version 1 du 12 octobre 2020
Living SARS-CoV-2 in feces suggesting possible fecal-oral contamination
Julie Dergham, Jeremy Delerce, Marielle Bedotto, Bernard La Scola, Valérie Moal

Link to the article

DOI : https://doi.org/10.35088/m6gc-d013

ÉPIDÉMIOLOGIE

Version 1 du 30 avril 2021
Control of common viral epidemics but not of SARS-CoV-2 through the application of hygiene and distancing measures
Audrey Giraud-Gatineau, Lancei Kaba, Céline Boschi, Christian Devaux, Jean-Paul Casalta, Philippe Gautret, Hervé Chaudet, Philippe Colson, Didier Raoult

Link to the article

DOI : https://doi.org/10.35088/e1e4-4v98

Version 1 du 18 février 2021
Life-years lost by COVID-19 patients in public hospitals of Marseille (APHM- South-Eastern France): a limited death toll
Sylvie Arlotto, Alice Gares, Audrey Giraud-Gatineau, Jean-Christophe Lagier, Marie Thèrese Jimeno, Patrick Peretti-Watel, Matthieu Million,Philippe Parola, Philippe Brouqui, Didier Raoult, Stephanie Gentile

Link to the article

Version 1 du 10 février 2021
The need for early management in patients with COVID-19
Audrey Giraud-Gatineau; Sébastien Cortaredona; Jean-Christophe Lagier; Matthieu Million; Philippe Brouqui; Yolande Obadia; Patrick Peretti-Watel; Didier Raoult; Stéphanie Gentile

Link to the article

DOI : https://doi.org/10.35088/f2eq-3a65

Version 1 du 8 février 2021
Mink, SARS-CoV-2, and the human-animal interface
F. Fenollar, O. Mediannikov, M. Maurin, C. Devaux, P. Colson, A. Levasseur, PE. Fournier, D. Raoult

Link to the article

DOI : https://doi.org/10.35088/gwvd-p422

Version 1 du 9 février 2021
Epidemiological surveillance of respiratory viral infections at IHU Méditerranée Infection and its application to SARS-CoV-2
Philippe COLSON, Audrey GIRAUD-GATINEAU & Didier RAOU

Link to the article

DOI : https://doi.org/10.35088/gpgh-wq98

Version 1 du 10 Juin 2020
Open screening of SARS-CoV-2 infections in the pediatric population in Marseille, Southern France
Aurélie Morand, PhD, MD1,2*, Tatiana Matteudi1, Alexandre Fabre, PhD, MD3,4, Philippe Minodier, MD5, Emmanuelle Bosdure, MD1, Léa Luciani, PharmD2, Jean-Christophe Dubus, PhD, MD1,6, Matthieu Million, PhD, MD2,6, Hervé Tissot-Dupont, MD2,6, Bernard La Scola, PhD, MD2,6, Philippe Colson, PhD, PharmD2,6, Didier Raoult, PhD, MD2,6, Brigitte Chabrol, PhD, MD1

In this cohort study we reported the first 302 pediatric SARS-CoV-2-positive patients in Marseille, mainly diagnosed thanks to open screening platform (80%).

Link to the article

Version 1 du 07 septembre 2020
Temporal and age distributions of SARS-CoV-2 and other coronaviruses, Southeastern France
Philippe COLSON, Vera ESTEVES-VIEIRA, Audrey GIRAUD-GATINEAU, Christine ZANDOTTI, Véronique FILOSA, Hervé CHAUDET, Jean-Christophe LAGIER, Didier RAOULT

doi: https://doi.org/10.35088/1e6e-5a17

Lire l’article

Version 1 du 1er septembre 2020
Differences pattern of the second outbreak of COVID-19 in Marseille, France
Philippe Gautret, Philippe Colson, Jean Christophe Lagier, Laurence Camoin-Jau, Audrey Giraud-Gatineau, Sophia Boudjema, Hervé Chaude, Didier Raoult

DOI : https://doi.org/10.35088/gsye-fd42

Title page
Table 1
Figure 1

Version 1 du 07 septembre 2020
Dramatic increase in the SARS-CoV-2 mutation rate and low mortality rate during the second epidemic in summer in Marseille
Philippe COLSON, Anthony LEVASSEUR, Jeremy DELERCE, Hervé CHAUDET, Vincent BOSSI, Mariem BEN KHEDHER, Pierre-Edouard FOURNIER, Jean-Christophe LAGIER, Didier RAOULT

doi: https://doi.org/10.35088/68c3-ew82

Lire l’article

Version 2 du 21 août 2020
Pattern of SARS-CoV-2 infection among dependant elderly residents living in retirement homes in Marseille, France, March-June 2020
Tran Duc Anh Ly, Didier Zanini, Vincent Laforge, Sylvie Arlotto, Stephanie Gentile, Helene Mendizabal, Michaël Finaud, David Morel, Olivier Quenette, Priscilla Malfuson-Clot-Faybesse, Alain Midejean, Phuc Le-Dinh, Gérard Daher, Berengere Labarriere, Anne-Marie Morel-Roux, Alain Coquet, Patrick Augier, Philippe Parola, Eric Chabriere, Didier Raoult, Philippe Gautret

Lire l’article

DOI : https://doi.org/10.35088/kt57-1t64

Version 2 du 30 mars 2020
Decreased mortality associated with respiratory viral infections between December 2019 and March 2020 compared to previous year, Southeast France
Audrey GIRAUD-GATINEAU, Philippe COLSON, Marie-Thérèse JIMENO, Christine ZANDOTTI, Laetitia NINOVE, Céline BOSCHI, JeanChristophe LAGIER, Bernard LA SCOLA, Hervé CHAUDET, Didier RAOULT

Link to the article

COMMENTARIES – PERSPECTIVES

21 juin 2021
Why has France not given itself the means to show the ineffectiveness of Hydroxychloroquine in COVID-19?
Matthieu MILLION, Sébastien CORTAREDONA, Philippe BROUQUI, Didier RAOULT

Link to the article

21 juin 2021
The War Against Chloroquine
Yanis Roussel, Philippe Gautret, Didier Raoult

Link to the article

31 mai 2021
Evaluating vaccination against SARS-CoV-2
Pierre-Édouard Fournier, Didier Raoult

Link to the article

DOI : https://doi.org/10.35088/eqt2-gf43

1er mars 2021
Do remdesivir and plasma therapy favor long-term SARS-CoV-2 infection and mutations in immunocompromised patients?
Philippe Gautret, Jean Christophe Lagier, Philippe Colson, Didier Raoult

Link to the article
Supplementary table

DOI : https://doi.org/10.35088/CYJP-NS88

16 février 2021
Does remdesivir favor long-term SARS-CoV-2 infection and mutations in immunocompromised patients ?
Philippe Gautret, Jean Christophe Lagier, Philippe Colson, Didier Raoult

Link to the letter 

DOI : https://doi.org/10.35088/01b5-wp20

16 février 2021
Who would accept a randomized trial in the context of covid-19 ?
Hervé Tissot-Dupont, Didier Raoult

Link to the article

DOI : https://doi.org/10.35088/tw79-2a97

12 février 2021
Opinion for the British Medical Journal – The War Against Chloroquine
Philippe Gautret, Didier Raoult

Link to the article

 

10 février 2021
Remdesivir could promote the occurrence of SARS-CoV-2 variants
Philippe COLSON, Christian A. DEVAUX, Didier RAOULT

Link to the article 

DOI : https://doi.org/10.35088/k9k5-qj41

Version 1 du 21 août 2020
Quousque tandem abutere, patientia nostra – Article soumis et rejeté par The New England Journal of Medecine
Didier Raoult, M.D, Ph.D., Jean-Christophe Lagier M.D, Ph.D., Philippe Brouqui, M.D., Ph.D., Philippe Parola, M.D, Ph.D.

Link to the article

DOI : https://doi.org/10.35088/cf1h-jk71

Version 1 du 30 juin 2020
Does IHU Mediterranean Infection influence Gilead stock price ?
Eric Chabrière

DOI : https://doi.org/10.35088/82z6-3×49

Version 1 du 30 juin 2020
Hydroxychloroquine recommendations toward the world : first evaluations
Yanis ROUSSEL, Didier RAOULT

Lire l’article

DOI : https://doi.org/10.35088/wjzn-1×68

Version 1 du 30 juin 2020
Remdesivir investigational trials in COVID-19: a critical reappraisal
P Brouqui, A Giraud-Gatineau & D Raoult

Lire l’article
Lettre à l’éditeur
Answer to reviewer’s comment and editor

DOI : https://doi.org/10.35088/6qpy-xx64

The Lancet Covid-19 Therapy Study: another miss-out
(On Covid-19 and Hydroxychloroquine The Lancet – SCANDAL)
Dragan Pavlovic

DOI : https://doi.org/10.35088/e4xq-1q16

Lire l’article

Version 2 du 18 Juin 2020
Why randomised Controlled Trials during epidemic
Philippe Brouqui, Didier Raoult

In epidemics there is an urgent need for new knowledge on drug efficacy to help policymakers fight the crisis. Yet the best research methodology to do this is a matter of debate, write Philippe Brouqui and Didier Raoult.

Link to the article

DOI : https://doi.org/10.35088/hedm-be95

SUBMITTED

Omar Osman I et al.
Expression of ACE2 receptor, soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin (1-7), is modulated in COVID-19 patients
JCI: submitted

Frutos R et al.
Understanding the origin of COVID-19 requires to change the paradigm for zoonotic emergence
Trends Microbiol.: submitted.

 

Devaux C.
Can ACE2 receptor polymorphism predict species susceptibility to SARS-CoV-2 ?
Front public health: submitted/research square DOI: 10.21203/rs.3.rs-25753/v1

Clinical observational studies and Cohorts

 

  • Julie Finance, Laurent Zieleskewicz, Paul Habert , Alexis Jacquier, Philippe Parola, Alain Boussuges , Fabienne Bregeon , Carole Eldin
    Non-radiating and low-radiating imaging for diagnosis and management of COVID-19 pneumonia
    J. Clin. Med. 2021, 10, 2196. https://doi.org/10.3390/jcm10102196 : https://www.mdpi.com/2077-0383/10/10/2196/pdf

 

  • Lagier, J. C., Million, M., Gautret, P., Colson, P., Cortaredona, S., Giraud-Gatineau, A., Honoré, S., Gaubert, J. Y., Fournier, P. E., Tissot-Dupont, H., Chabrière, E., Stein, A., Deharo, J. C., Fenollar, F., Rolain, J. M., Obadia, Y., Jacquier, A., La Scola, B., Brouqui, P., Drancourt, M., … IHU COVID-19 Task force (2020).
    Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis.
    Travel medicine and infectious disease, 36, 101791. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315163/

 

  • Philippe Brouqui, Philippe Colson, Cléa Melenotte, Linda Houhamdi, Marielle Bedotto, Christian Devaux, Philipe Gautret, Matthieu Million, Philippe Parola, Didier Stoupan, Bernard La Scola, Jean-Christophe Lagier, Didier Raoult
    COVID-19 re-infection
    European Society for Clinical Investigation Journal Foundation –  https://onlinelibrary.wiley.com/doi/10.1111/eci.13537

 

 

 

  • Aherfi S, Gautret P, Chaudet H, Raoult D, La Scola B.
    Clusters of COVID-19 associated with Purim celebration in the Jewish community in Marseille, France, March 2020 [published online ahead of print, 2020 Aug 20].
    Int J Infect Dis. 2020;S1201-9712(20)30679-2. doi:10.1016/j.ijid.2020.08.049 https://pubmed.ncbi.nlm.nih.gov/32829043/

 

 

  • Colson P, Rolain JM, Raoult D.
    Chloroquine for the 2019 novel coronavirus SARS-CoV-2.
    Int J Antimicrob Agents. 2020;55(3):105923. doi:10.1016/j.ijantimicag.2020.105923 https://pubmed.ncbi.nlm.nih.gov/32070753/

 

  • Colson P, Rolain JM, Lagier JC, Brouqui P, Raoult D.
    Chloroquine and hydroxychloroquine as available weapons to fight COVID-19.
    Int J Antimicrob Agents. 2020;55(4):105932. doi:10.1016/j.ijantimicag.2020.105932 https://pubmed.ncbi.nlm.nih.gov/32145363/

 

 

  • Brouqui P, Giraud-Gatineau A, Raoult D.
    Remdesivir investigational trials in COVID-19: a critical reappraisal [published online ahead of print, 2020 Jun 7].
    New Microbes New Infect. 2020;100707. doi:10.1016/j.nmni.2020.100707 https://pubmed.ncbi.nlm.nih.gov/32837727/

 

 

  • Wargny M, Gourdy P, Ludwig L, Seret-Bégué D, Bourron O, Darmon P, Amadou C, Pichelin M, Potier L, Thivolet C, Gautier JF, Hadjadj S, Cariou B; CORONADO investigators.
    Type 1 Diabetes in People Hospitalized for COVID-19: New Insights From the CORONADO Study.
    Diabetes Care. 2020 Aug 26:dc201217. doi: 10.2337/dc20-1217. Epub ahead of print. PMID: 32847826.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576421/

 

  • Gonçalves A, Bertrand J, Ke R, Comets E, de Lamballerie X, Malvy D, Pizzorno A, Terrier O, Rosa Calatrava M, Mentré F, Smith P, Perelson AS, Guedj J.
    Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load.
    CPT Pharmacometrics Syst Pharmacol. 2020 Jun 18;9(9):509–14. doi: 10.1002/psp4.12543. Epub ahead of print. PMID: 32558354; PMCID: PMC7323384. https://pubmed.ncbi.nlm.nih.gov/32558354/

 

  • Eloy P, Solas C, Touret F, Mentré F, Malvy D, de Lamballerie X, Guedj J.
    Dose Rationale for Favipiravir Use in Patients Infected With SARS-CoV-2.
    Clin Pharmacol Ther. 2020 Aug;108(2):188. doi: 10.1002/cpt.1877. Epub 2020 May 21. PMID: 32350860. https://pubmed.ncbi.nlm.nih.gov/32350860/

 

  • Gautret, P., Lagier, J. C., Parola, P., Hoang, V. T., Meddeb, L., Mailhe, M., Doudier, B., Courjon, J., Giordanengo, V., Vieira, V. E., Tissot Dupont, H., Honoré, S., Colson, P., Chabrière, E., La Scola, B., Rolain, J. M., Brouqui, P., & Raoult, D. (2020).
    Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
    International journal of antimicrobial agents, 56(1), 105949. https://doi.org/10.1016/j.ijantimicag.2020.105949

 

  • Didier Raoult, Matthieu Million, Philippe Gautret, Jean-Christophe Lagier, Philippe Colson, Philippe Parola, and Jean-Marc Rolain.
    Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial : Response to David Spencer (Elsevier).
    Published online 08/07/2020: https://doi.org/10.35088/bjjr-cy47

 

  • Gautret, P., Lagier, J. C., Parola, P., Hoang, V. T., Meddeb, L., Sevestre, J., Mailhe, M., Doudier, B., Aubry, C., Amrane, S., Seng, P., Hocquart, M., Eldin, C., Finance, J., Vieira, V. E., Tissot-Dupont, H. T., Honoré, S., Stein, A., Million, M., Colson, P., … Raoult, D. (2020).
    Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
    Travel medicine and infectious disease, 34, 101663. https://doi.org/10.1016/j.tmaid.2020.101663 https://pubmed.ncbi.nlm.nih.gov/32289548/

 

  • Million, M., Lagier, J. C., Gautret, P., Colson, P., Fournier, P. E., Amrane, S., Hocquart, M., Mailhe, M., Esteves-Vieira, V., Doudier, B., Aubry, C., Correard, F., Giraud-Gatineau, A., Roussel, Y., Berenger, C., Cassir, N., Seng, P., Zandotti, C., Dhiver, C., Ravaux, I., … Raoult, D. (2020).
    Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France.
    Travel medicine and infectious disease, 35, 101738. https://doi.org/10.1016/j.tmaid.2020.101738 https://pubmed.ncbi.nlm.nih.gov/32387409/

 

  • La Scola, B., Le Bideau, M., Andreani, J., Hoang, V. T., Grimaldier, C., Colson, P., Gautret, P., & Raoult, D. (2020)
    Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 39(6), 1059–1061. https://doi.org/10.1007/s10096-020-03913-9https://pubmed.ncbi.nlm.nih.gov/32342252/

 

  • Baron SA, Devaux C, Colson P, Raoult D, Rolain JM.
    Teicoplanin: an alternative drug for the treatment of COVID-19?
    Int J Antimicrob Agents. 2020;55(4):105944. doi:10.1016/j.ijantimicag.2020.105944 https://pubmed.ncbi.nlm.nih.gov/32179150/

Tran Duc Anh Ly, Didier Zanini, Vincent Laforge, Sylvie Arlotto, Stephanie Gentile, Helene Mendizabal, Michaël Finaud, David Morel, Olivier Quenette, Priscilla Malfuson-Clot-Faybesse, Alain Midejean, Phuc Le-Dinh, Gérard Daher, Berengere Labarriere, Anne-Marie Morel-Roux, Alain Coquet, Patrick Augier, Philippe Parola, Eric Chabriere, Didier Raoult, Philippe Gautret
Pattern of SARS-CoV-2 infection among dependant elderly residents living in long-term care facilities in Marseille, France, March–June 2020
International Journal of Antimicrobial Agents, Available online 13 November 2020, 106219 https://www.sciencedirect.com/science/article/pii/S0924857920304301

VIROLOGY – ISOLATION – IN VITRO TESTING

 

 

  • Gendrot M, Andreani J, Boxberger M, Jardot P, Fonta I, Le Bideau M, Duflot I, Mosnier J, Rolland C, Bogreau H, Hutter S, La Scola B, Pradines B.
    Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation.
    Travel Med Infect Dis. 2020 Sep 8;37:101873. doi: 10.1016/j.tmaid.2020.101873. Epub ahead of print. PMID: 32916297; PMCID: PMC7477610. https://pubmed.ncbi.nlm.nih.gov/32916297/

 

  • Touret F, Gilles M, Barral K, Nougairède A, van Helden J, Decroly E, de Lamballerie X, Coutard B.
    In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication.
    Sci Rep. 2020 Aug 4;10(1):13093. doi: 10.1038/s41598-020-70143-6. PMID: 32753646; PMCID: PMC7403393. https://pubmed.ncbi.nlm.nih.gov/32753646/

 

  • Maisonnasse P, Guedj J, Contreras V, Behillil S, Solas C, Marlin R, Naninck T, Pizzorno A, Lemaitre J, Gonçalves A, Kahlaoui N, Terrier O, Fang RHT, Enouf V, Dereuddre-Bosquet N, Brisebarre A, Touret F, Chapon C, Hoen B, Lina B, Calatrava MR, van der Werf S, de Lamballerie X, Le Grand R.
    Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates.
    Nature. 2020 Sep;585(7826):584-587. doi: 10.1038/s41586-020-2558-4. Epub 2020 Jul 22. PMID: 32698191. https://pubmed.ncbi.nlm.nih.gov/32698191/

 

  • Pastorino B, Touret F, Gilles M, de Lamballerie X, Charrel RN.
    Heat Inactivation of Different Types of SARS-CoV-2 Samples: What Protocols for Biosafety, Molecular Detection and Serological Diagnostics?
    2020 Jul 7;12(7):735. doi: 10.3390/v12070735. PMID: 32646015; PMCID: PMC7412566. https://pubmed.ncbi.nlm.nih.gov/32646015/

 

  • Pastorino B, Touret F, Gilles M, Luciani L, de Lamballerie X, Charrel RN.
    Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples.
    2020 Jun 8;12(6):624. doi: 10.3390/v12060624. PMID: 32521706; PMCID: PMC7354533. https://pubmed.ncbi.nlm.nih.gov/32521706/

 

  • Gendrot M, Andreani J, Jardot P, Hutter S, Delandre O, Boxberger M, Mosnier J, Le Bideau M, Duflot I, Fonta I, Rolland C, Bogreau H, La Scola B, Pradines B.
    In vitro antiviral activity of doxycycline against SARS-CoV-2.
    Molecules, 2020, 25 :5064. Doi: 10.3390/molecules25215064 https://pubmed.ncbi.nlm.nih.gov/33142770/

 

  • Gendrot M, Andreani J, Duflot I, Boxberger M, Le Bideau M, Mosnier J, Jardot P, Fonta I, Rolland C, Bogreau H, Hutter S, La Scola B, Pradines B.
    Methylene blue inhibits the replication of SARS-CoV-2 in vitro.
    Int J Antimicrob Agents, 2020, 106202. Doi: 10.1016/j.ijantimicag.2020.106202 https://pubmed.ncbi.nlm.nih.gov/33075512/

 

  • Gendrot M, Duflot I, Boxberger M, Delandre O, Jardot P, Le Bideau M, Andreani J, Fonta I, Mosnier J, Rolland C, Hutter S, La Scola B, Pradines B.
    Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate.
    Int J Infect Dis, 2020, 99 :437-440. Doi: 10.1016/j.ijid.2020.08.032 https://pubmed.ncbi.nlm.nih.gov/32805422/

GENOMICS

  • Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E.
    The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
    Antiviral Res. 2020 Apr;176:104742. doi: 10.1016/j.antiviral.2020.104742. Epub 2020 Feb 10. PMID: 32057769; PMCID: PMC7114094.

MICROSCOPY

  • Francis R, Le Bideau M, Jardot P, Grimaldier C, Raoult D, Bou Khalil JY, La Scola B.
    High-speed large-scale automated isolation of SARS-CoV-2 from clinical samples using miniaturized co-culture coupled to high-content screening.
    Clin Microbiol Infect. 2020 Sep 23:S1198-743X(20)30570-X. doi: 10.1016/j.cmi.2020.09.018. Epub ahead of print. PMID: 32979576; PMCID: PMC7510445.

 

  • Colson P, Lagier JC, Baudoin JP, Bou Khalil J, La Scola B, Raoult D.
    Ultrarapid diagnosis, microscope imaging, genome sequencing, and culture isolation of SARS-CoV-2.
    Eur J Clin Microbiol Infect Dis. 2020;39(8):1601-1603. doi:10.1007/s10096-020-03869-w https://pubmed.ncbi.nlm.nih.gov/32270412/

 

  • Djamal Brahim Belhaouari, Anthony Fontanini, Jean-Pierre Baudoin, Gabriel Haddad, Marion Le Bideau, Jacques Yaacoub Bou Khalil, Didier Raoult and Bernard La Scola.
    The strengths of scanning electron microscopy in deciphering SARS-CoV-2 infectious cycle.
    Frontiers in Microbiology VOLUME=11 YEAR=2020 PAGES=2014   3389/fmicb.2020.02014 https://www.frontiersin.org/article/10.3389/fmicb.2020.02014

IMMUNOLOGY

 

  • Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen J, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort, Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL. Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020 Sep 24:eabd4585. doi: 10.1126/science.abd4585. Epub ahead of print. PMID: 32972996.

 

  • Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Çölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela ŞN, Gallego CR, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-19; Biobank; COVID Human Genetic Effort; NIAID-USUHS; TAGC COVID Immunity Group, Snow AL, Dalgard CL, Milner J, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli M, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton R, Zhang SY, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science. 2020 Sep 24:eabd4570. doi: 10.1126/science.abd4570. Epub ahead of print. PMID: 32972995.

 

  • Melenotte C, Silvin A, Goubet AG, Lahmar I, Dubuisson A, Zumla A, Raoult D, Merad M, Gachot B, Hénon C, Solary E, Fontenay M, André F, Maeurer M, Ippolito G, Piacentini M, Wang FS, Ginhoux F, Marabelle A, Kroemer G, Derosa L, Zitvogel L.
    Immune responses during COVID-19 infection.
    Oncoimmunology. 2020 Aug 25;9(1):1807836. doi: 10.1080/2162402X.2020.1807836. PMID: 32939324; PMCID: PMC7480812.

 

  • Vitte J, Michel M, Mezouar S, Diallo AB, Boumaza A, Mege JL, Desnues B.
    Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines.
    Front Immunol. 2020 Aug 28;11:2159. doi: 10.3389/fimmu.2020.02159. PMID: 32983179; PMCID: PMC7484884.

 

  • Vitte J, Diallo AB, Boumaza A, Lopez A, Michel M, Allardet-Servent J, Mezouar S, Sereme Y, Busnel JM, Miloud T, Malergue F, Morange PE, Halfon P, Olive D, Leone M, Mege JL.
    A granulocytic signature identifies COVID-19 and its severity.
    J Infect Dis. 2020 Sep 17:jiaa591. doi: 10.1093/infdis/jiaa591. Epub ahead of print. PMID: 32941618; PMCID: PMC7543529.
  • Pierre-Edouard FOURNIER,
    Contribution of VitaPCR SARS-CoV-2 to the emergency diagnosis of COVID-19
    In press Journal of Clinical Virology.

DIAGNOSIS

  • Amrane, S., Tissot-Dupont, H., Doudier, B., Eldin, C., Hocquart, M., Mailhe, M., Dudouet, P., Ormières, E., Ailhaud, L., Parola, P., Lagier, J. C., Brouqui, P., Zandotti, C., Ninove, L., Luciani, L., Boschi, C., La Scola, B., Raoult, D., Million, M., Colson, P., … Gautret, P. (2020).
    Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France – January 31st to March 1st, 2020: A respiratory virus snapshot.
    Travel medicine and infectious disease, 101632. Advance online publication. https://doi.org/10.1016/j.tmaid.2020.101632

 

  • Boudjema S, Finance J, Coulibaly F, Meddeb L, Tissot-Dupont H, Michel M, Lagier JC, Million M, Radulesco T, Michel J, Brouqui P, Raoult D, Fenollar F, Parola P.
    Olfactory and gustative disorders for the diagnosis of COVID-19.
    Travel Med Infect Dis. 2020 Sep 6;37:101875. doi: 10.1016/j.tmaid.2020.101875. Epub ahead of print. PMID: 32898703; PMCID: PMC7474847.

 

  • Jaafar R, Aherfi S, Wurtz N, Grimaldier C, Hoang VT, Colson P, Raoult D, La Scola B.
    Correlation between 3790 qPCR positives samples and positive cell cultures including 1941 SARS-CoV-2 isolates.
    Clin Infect Dis. 2020 Sep 28:ciaa1491. doi: 10.1093/cid/ciaa1491. Epub ahead of print. PMID: 32986798; PMCID: PMC7543373.

 

  • Pezzi L, Charrel RN, Ninove L, Nougairede A, Molle G, Coutard B, Durand G, Leparc-Goffart I, de Lamballerie X, Thirion L.
    Development and Evaluation of a duo SARS-CoV-2 RT-qPCR Assay Combining Two Assays Approved by the World Health Organization Targeting the Envelope and the RNA-Dependant RNA Polymerase (RdRp) Coding Regions.
    Viruses. 2020 Jun 25;12(6):686. doi: 10.3390/v12060686. PMID: 32630601; PMCID: PMC7354606.

 

  • Pastorino B, Touret F, Gilles M, de Lamballerie X, Charrel RN.
    Prolonged Infectivity of SARS-CoV-2 in Fomites.
    Emerg Infect Dis. 2020 Sep;26(9):2256–7. doi: 10.3201/eid2609.201788. Epub 2020 Jun 24. PMID: 32579874; PMCID: PMC7454106.

 

  • Nathalie Wurtz, Gwilherm Penant, Priscilla Jardot, Nathalie Duclos and Bernard La Scola
    Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity and differences in growth profile
    European Journal of Clinical Microbiology & Infectious Diseases

EPIDEMIOLOGY

  • Younes Laidoudi, Youssouf Sereme, Hacène Medkour, Stéphanie Watier-Grillot, Pierre Scandola, Jacques Ginesta, Virginie Andréo, Claire Labarde, Loïc Comtet, Philippe Pourquier, Didier Raoult, Jean-Lou Marié, Bernard Davoust
    SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assay
    One Health 13 (2021) 100293
    Link to the PDF version

 

 

 

 

  • Giraud-Gatineau, A., Colson, P., Jimeno, M. T., Zandotti, C., Ninove, L., Boschi, C., Lagier, J. C., La Scola, B., Chaudet, H., & Raoult, D. (2020).
    Comparison of mortality associated with respiratory viral infections between December 2019 and March 2020 with that of the previous year in Southeastern France.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 96, 154–156. https://doi.org/10.1016/j.ijid.2020.05.001. https://pubmed.ncbi.nlm.nih.gov/32389848/

 

  • Colson, P., Tissot-Dupont, H., Morand, A., Boschi, C., Ninove, L., Esteves-Vieira, V., Gautret, P., Brouqui, P., Parola, P., Lagier, J. C., Zandotti, C., Million, M., La Scola, B., & Raoult, D. (2020).
    Children account for a small proportion of diagnoses of SARS-CoV-2 infection and do not exhibit greater viral loads than adults.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1–5. Advance online publication. https://doi.org/10.1007/s10096-020-03900-0https://pubmed.ncbi.nlm.nih.gov/32845413/

 

  • Colson, P., La Scola, B., Esteves-Vieira, V., Ninove, L., Zandotti, C., Jimeno, M. T., Gazin, C., Bedotto, M., Filosa, V., Giraud-Gatineau, A., Chaudet, H., Brouqui, P., Lagier, J. C., & Raoult, D. (2020).
    Letter to the editor: Plenty of coronaviruses but no SARS-CoV-2.
    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 25(8), 2000171. https://doi.org/10.2807/1560-7917.ES.2020.25.8.2000171. https://pubmed.ncbi.nlm.nih.gov/32127122/

 

  • Colson P, Esteves-Vieira V, Giraud-Gatineau A, Zandotti C, Filosa V, Chaudet H, Lagier JC, Raoult D.
    Temporal and age distributions of SARS-CoV-2 and other coronaviruses, Southeastern France.
    Int J Infect Dis. 2020 Sep 22:S1201-9712(20)32133-0. doi: 10.1016/j.ijid.2020.09.1417. Epub ahead of print. PMID: 32976991; PMCID: PMC7511210.

 

  • Gautret P, Colson P, Lagier JC, Camoin-Jau L, Giraud-Gatineau A, Boudjema S, Finance J, Chaudet H, Raoult D.
    Different pattern of the second outbreak of COVID-19 in Marseille, France.
    Int J Infect Dis. 2020 Oct 7:S1201-9712(20)32208-6. doi: 10.1016/j.ijid.2020.10.005. Epub ahead of print. PMID: 33038556.

 

  • Gallian P, Pastorino B, Morel P, Chiaroni J, Ninove L, de Lamballerie X.
    Lower prevalence of antibodies neutralizing SARS-CoV-2 in group O French blood donors.
    Antiviral Res. 2020 Sep;181:104880. doi: 10.1016/j.antiviral.2020.104880. Epub 2020 Jul 15. PMID: 32679056; PMCID: PMC7362788.

 

  • Laloui R, Bakour S, Raoult D, Verger P, Sokhna C, Devaux C, Pradines B, Rolain JM.
    What could explain the late emergence of COVID-19 in Africa?
    New Microbes New Infect, 2020, 38 :100760. Doi: 10.1016/j.nmni.2020.100760

HUMAN AND SOCIAL SCIENCES

  • Ward JK, Alleaume C, Peretti-Watel P; COCONEL Group.
    The French public’s attitudes to a future COVID-19 vaccine: The politicization of a public health issue.
    Social Science and Medicine, 265:113414. doi: 10.1016/j.socscimed.2020.113414.

 

  • COCONEL Study Group.
    Attitudes about COVID-19 Lockdown among General Population, France, March 2020.
    Emerging Infectious Diseases (à paraître).

 

  • Peretti-Watel P, Alleaume C, Léger D, Beck F, Verger P.
    Anxiety, depression and sleep problems: a second wave of COVID-19.
    General Psychiatry, 33 (5) e100299; DOI: 10.1136/gpsych-2020-100299.

 

  • Léger D., Beck F., Fressard L., Verger P., Peretti-Watel P., and the COCONEL Group.
    Poor Sleep Associated with Overuse of Media during the COVID-19 Lockdown.
    Sleep doi: 10.1093/sleep/zsaa125.

 

  • Patrick Peretti-Watel and the COCONEL Study Group.
    A future vaccination campaign against COVID-19 at risk of vaccine hesitancy and politicization.
    Lancet Infectious Diseases, 2020. doi: 10.1016/S1473-3099(20)30426-6.

 

  • Beck F., Léger D., Fressard L., Peretti-Watel P., Verger P. & the COCONEL group.
    Covid-19 health crisis and lockdown associated with high level of sleep complaints and hypnotic uptake at the population level.
    Journal of Sleep Research. doi: 10.1111/jsr.13119.

 

  • Lambert A, Cayouette-Remblière J,  Guéraut É,  Le Roux G,  Bonvalet C,  Girard V,  Langlois L.
    Le travail et ses aménagements : ce que la pandémie de covid-19a changé pour les Français,
    Population & Sociétés, Numéro 579,

 

  • Lambert A, Cayouette-Remblière J, Guéraut É, Le Roux G, Bonvalet C, Girard V, Langlois L.
    Comment voisine-t-on dans la France confinée ?
    Population & Sociétés, Numéro 578, juillet 2020.

COMMENTARIES – PERSPECTIVES

 

  • Lagier, J. C., Colson, P., Tissot Dupont, H., Salomon, J., Doudier, B., Aubry, C., Gouriet, F., Baron, S., Dudouet, P., Flores, R., Ailhaud, L., Gautret, P., Parola, P., La Scola, B., Raoult, D., & Brouqui, P. (2020).
    Testing the repatriated for SARS-Cov2: Should laboratory-based quarantine replace traditional quarantine?
    Travel medicine and infectious disease, 34, 101624. https://doi.org/10.1016/j.tmaid.2020.101624https://pubmed.ncbi.nlm.nih.gov/32179125/

 

 

 

 

  • Javelle E, Raoult D.
    COVID-19 pandemic more than a century after the Spanish flu [published online ahead of print, 2020 Aug 11].
    Lancet Infect Dis. 2020;S1473-3099(20)30650-2. doi:10.1016/S1473-3099(20)30650-2 https://pubmed.ncbi.nlm.nih.gov/32795410/

 

  • Raoult D, Zumla A, Locatelli F, Ippolito G, Kroemer G.
    Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses.
    Cell Stress. 2020;4(4):66-75. Published 2020 Mar 2. doi:10.15698/cst2020.04.216 https://pubmed.ncbi.nlm.nih.gov/32292881/

 

  • Devaux CA, Rolain JM, Raoult D.
    ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome.
    J Microbiol Immunol Infect. 2020;53(3):425-435. doi:10.1016/j.jmii.2020.04.015 https://pubmed.ncbi.nlm.nih.gov/32414646/

 

  • Roussel Y, Raoult D.
    Hydroxychloroquine recommendations toward the world: first evaluations.
    New Microbes New Infect. 2020 Sep 22:100759. doi: 10.1016/j.nmni.2020.100759. Epub ahead of print. PMID: 32983541; PMCID: PMC7508006.

 

 

  • Lalaoui R, Bakour S, Raoult D, Verger P, Sokhna C, Devaux C, Pradines B, Rolain JM.
    What could explain the late emergence of COVID-19 in Africa?
    New Microbes New Infect. 2020 Nov;38:100760. doi: 10.1016/j.nmni.2020.100760. Epub 2020 Sep 22. PMID: 32983542; PMCID: PMC7508045.

 

  • Raoult D.
    Lancet gate: a matter of fact or a matter of concern.
    New Microbes New Infect. 2020 Nov;38:100758. doi: 10.1016/j.nmni.2020.100758. Epub 2020 Sep 22. PMID: 32983540; PMCID: PMC7508049.

 

  • Million M, Roussel Y, Lagier JC, Raoult D.
    Re: ‘effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients’ by Fiolet et al.
    Clin Microbiol Infect. 2020 Sep 24:S1198-743X(20)30578-4. doi: 10.1016/j.cmi.2020.09.026. Epub ahead of print. PMID: 32980527.

 

  • Touret F, de Lamballerie X.
    Of chloroquine and COVID-19.
    Antiviral Res. 2020 May;177:104762. doi: 10.1016/j.antiviral.2020.104762. Epub 2020 Mar 5. PMID: 32147496; PMCID: PMC7132364.

 

  • Frutos R, Serra-Cobo J, Chen T, Devaux CA.
    COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans.
    Infect Genet Evol. 2020 Oct;84:104493. doi: 10.1016/j.meegid.2020.104493. Epub 2020 Aug 5. PMID: 32768565; PMCID: PMC7405773.

 

  • Frutos R, Lopez Roig M, Serra-Cobo J, Devaux CA.
    COVID-19: The Conjunction of Events Leading to the Coronavirus Pandemic and Lessons to Learn for Future Threats.
    Front Med (Lausanne). 2020 May 12;7:223. doi: 10.3389/fmed.2020.00223. PMID: 32574324; PMCID: PMC7235412.

 

  • Devaux CA, Rolain JM, Colson P, Raoult D.
    New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
    Int J Antimicrob Agents. 2020;55(5):105938. doi:10.1016/j.ijantimicag.2020.105938 https://pubmed.ncbi.nlm.nih.gov/32171740/

 

  • Raoult D.
    Rational for meta-analysis and randomized treatment: the COVID-19 example.
    Clin Microbiol Infect. 2020 Oct 21:S1198-743X(20)30643-1. doi: 10.1016/j.cmi.2020.10.012. Epub ahead of print. PMID: 33098998.

 

  • Roussel Y, Million M, Chabriere E, Lagier JC, Raoult D.
    Be careful with Big Data: Re-analysis of Patient Characteristics and Outcomes of 11,721 Patients with COVID19 Hospitalized Across the United States.
    Clin Infect Dis. 2020 Oct 22:ciaa1618. doi: 10.1093/cid/ciaa1618. Epub ahead of print. PMID: 33086376.

 

  • Devaux C.
    Are ACE inhibitors and ARBs more beneficial than harmful in the treatment of severe COVID-19 disease?
    J. Cardiovascular Med. Cardio. : 7(2): 101-103. DOI: https://dx.doi.org/10.17352/2455-2976.000122

 

  • Gendrot M, Javelle E, Clerc A, Savini H, Pradines B.
    Chloroquine as a prophylactic agent against COVID-19?
    Int J Antimicrob Agents, 2020, 55 :105980. Doi: 10.1016/j.ijantimicag.2020.105980

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